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    GENE:

    RNF217-AS1 (RNF217 Antisense RNA 1 (Head To Head))

    i
    Other names: RNF217-AS1, RNF217 Antisense RNA 1 (Head To Head), Six-Twelve Leukemia, RNF217-AS1, STL
    7ms
    Regulatory Role and Mechanism of lncRNA RNF217-AS1 in the Proliferation and Migration of Esophageal Cancer Cells. (PubMed, Cancer Manag Res)
    Furthermore, the protein levels of HOXA1, fibronectin, and FOXC2 were downregulated, while GRHL2 and E-cadherin expressions were increased in the si-RNF217-AS1 group (P<0.01). RNF217-AS1 is upregulated in esophageal cancer cells, and its downregulation inhibits the proliferation, migration and EMT of esophageal cancer cells by regulating the miR-377-3p/HOXA1 axis.
    Journal
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    CDH1 (Cadherin 1) • FN1 (Fibronectin 1) • RNF217-AS1 (RNF217 Antisense RNA 1 (Head To Head)) • FOXC2 (Forkhead Box C2)
    over1year
    The short peptide encoded by long non-coding RNA RNF217-AS1 inhibits stomach cancer tumorigenesis, macrophage recruitment, and pro-inflammatory responses. (PubMed, Amino Acids)
    The RNF217-AS1 ORF-encoded peptide in human SC AGS cells suppressed THP-1 cell migration, triggered the differential expression of CXCL1/CXCL2/CXCL8/CXCL12, and inactivated the TLR4/NF-κB/STAT1 signaling pathways. As a conclusion, the RNF217-AS1 ORF-encoded peptide hindered SC progression in vitro and in vivo and suppressed macrophage recruitment and pro-inflammatory responses in SC.
    Journal
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    CXCL8 (Chemokine (C-X-C motif) ligand 8) • CXCL12 (C-X-C Motif Chemokine Ligand 12) • TLR4 (Toll Like Receptor 4) • NR2F1 (Nuclear Receptor Subfamily 2 Group F Member 1) • RNF217-AS1 (RNF217 Antisense RNA 1 (Head To Head)) • CXCL1 (Chemokine (C-X-C motif) ligand 1) • NR2F1-AS1 (NR2F1 Antisense RNA 1)
    over2years
    Multi-omics Analysis Classifies Colorectal Cancer into Distinct Methylated Immunogenic and Angiogenic Subtypes Based on Anatomical Laterality. (PubMed, Indian J Surg Oncol)
    Our study exemplifies the translational competence and robustness of machine learning in effective translational bridging of research and clinic. The online version contains supplementary material available at 10.1007/s13193-023-01760-6.
    Journal
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    MAD2L2 (Mitotic Arrest Deficient 2 Like 2) • RNF217-AS1 (RNF217 Antisense RNA 1 (Head To Head)) • SOX11 (SRY-Box Transcription Factor 11) • ABCA1 (ATP Binding Cassette Subfamily A Member 1) • MIR10B (MicroRNA 10b)