RNF207 (Ring Finger Protein 207)

Clinically, elevated RNF207 expression in osteosarcoma patients serves as a biomarker for aggressive disease and unfavorable prognosis. Functionally, RNF207 drives osteosarcoma progression in vitro and in vivo by ubiquitinating and degrading KCNQ1 to hyperactivate MAPK signaling. These findings identify RNF207 as a novel therapeutic target and prognostic marker for osteosarcoma.

The HadVCi score may be an effective tool for survival prediction and treatment guidance in patients with glioma.

Using published literature and comparative analyses of related disease-causing genes, 6 of the 19 genes (ALKBH7, MYCBP, MZF1, RNF207, RRS1, and TUSC2) were screened as genes with mutations in patients and had higher mutation rates in reproductive cancers. Pathway analysis showed that downregulated genes in non-HPV cervical cancer were mainly related to the immune system response, suggesting that non-HPV cervical cancer differs from HPV-infected cervical cancer in that the immune response is weaker, which is consistent with the weak correlation with viral infection.