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    BIOMARKER:

    RNASE7 expression

    i
    Other names: RNASE7, Ribonuclease A Family Member 7, Skin-Derived Antimicrobial Protein 2, Ribonuclease, RNase A Family, 7, Ribonuclease 7, RNase 7, SAP-2, RAE1,
    Entrez ID:
    84659
    Related biomarkers:
    Others
    almost2years
    RAE1 promotes gastric carcinogenesis and epithelial-mesenchymal transition. (PubMed, Arch Biochem Biophys)
    RAE1 promotes GC cell migration and invasion through the ERK/MAPK pathway and is a potential therapeutic target for GC therapy.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CDH1 (Cadherin 1) • VIM (Vimentin) • CDH2 (Cadherin 2) • RNASE7 (Ribonuclease A Family Member 7) • ZEB1 (Zinc Finger E-box Binding Homeobox 1)
    |
    MYC expression • CDH1 expression • VIM expression • RNASE7 expression • ZEB1 expression
    |
    SCH772984
    over3years
    Analysis of COVID-19-Associated Proteins Identifies TANK-Binding Kinase 1 As an Immunotherapeutic Target in Multiple Myeloma (ASH 2022)
    Taken together, we show that TBK1 is downregulated in pDCs, and pDCs interacting with MM cells further decrease TBK1 expression in MM cells, thereby attenuating IFN-mediated anti-viral immune response signaling. Our findings suggest that: 1) low levels of TBK1 may confer increased susceptibility of MM patients to COVID-19 and 2) targeting TBK1 may restore the anti-viral immune response and reduce COVID-19 severity in MM.
    IO biomarker
    |
    RNASE7 (Ribonuclease A Family Member 7) • IFNA1 (Interferon Alpha 1) • IRF3 (Interferon Regulatory Factor 3)
    |
    RNASE7 expression
    over3years
    Orthotopic and Heterotopic Murine Models of Pancreatic Cancer Exhibit Different Immunological Microenvironments and Different Responses to Immunotherapy. (PubMed, Front Immunol)
    In summary, this study describes construction of a novel orthotopic PDAC model through implantation of tissue slices and discusses resistance to immunotherapy from the perspective of a PDAC microenvironment. Based on the obtained results, it is evident that elimination MDSCs by NKG2D CAR could rescue the impaired CAR-T cell activity.
    Preclinical • Journal
    |
    NKG2D (killer cell lectin like receptor K1)
    |
    RNASE7 expression
    over3years
    RAE1 is a prognostic biomarker and is correlated with clinicopathological characteristics of patients with hepatocellular carcinoma. (PubMed, BMC Bioinformatics)
    RAE1 can be a potential diagnostic and prognostic biomarker associated with microtubules and a therapeutic target for HCC.
    Journal
    |
    AFP (Alpha-fetoprotein) • NUP214 (Nucleoporin 214) • RNASE7 (Ribonuclease A Family Member 7) • NXF1 (Nuclear RNA Export Factor 1)
    |
    RNASE7 expression