P4, N=116, Not yet recruiting, Southern Medical University Southern Hospital; Southern Medical University Southern Hospital

Cancer chemotherapy mainly vincristine, dactinomycin, and cyclophosphamide, surgery, radiotherapy, and brachytherapy were the common keywords of treatment. The more common keywords such as age, facial neoplasms, mouth neoplasms, orbital neoplasms, gingiva, mandible, DNA-binding proteins, gene silencing, and Rh30 cell line were reported by stomatologists. This study is the first comprehensive report of the scientometric characteristics of RMS publications by pediatricians and stomatologists, highlighting the need for increased awareness among clinicians to avoid diagnostic delays and ensure timely treatment.

P3, N=1134, Recruiting, NICHD Global Network for Women's and Children's Health | Not yet recruiting --> Recruiting

NSUN2-mediated m5C modification of EPYC contributed to GC cell growth and metastasis, which provided a novel regulatory axis for understanding the pathogenesis of GC.

Rutin mitigates THP-induced cardiotoxicity and enhances chemotherapeutic efficacy via the novel miR-129-1-3p/GRIN2D pathway. Our data show miR-129-1-3p to be an essential mediator, and suggest that the rutin-miR-129-1-3p-GRIN2D axis is a favorable target for improving the safety and effectiveness of breast cancer chemotherapy.

P=N/A, N=250, Recruiting, University of Minnesota | Trial primary completion date: Dec 2025 --> Dec 2026

P4, N=78, Completed, Johns Hopkins Bloomberg School of Public Health | Active, not recruiting --> Completed

Although apoptosis is eventually induced in TM3 cells, protective autophagy is also activated to mitigate the cytotoxic impact of the combination treatment. This finding may provide a reference for the development of safe therapeutic regimen for Leydig cell tumors.

Future research should prioritize pharmacokinetic characterization, investigation of combinatorial therapeutic strategies, and pathways toward clinical translation. Intracellular exposure appears to be shaped by two complementary axes: interference with 3'end polyadenylation and ENT1/ENT2-mediated uptake with ADA-catalyzed deamination.

P2, N=127, Recruiting, Second Affiliated Hospital of Soochow University | Not yet recruiting --> Recruiting

Collectively, COR inhibited MM progression by inducing ferroptosis through upregulating CLEC2. The online version contains supplementary material available at 10.1007/s10616-025-00886-5.

Mechanistic investigations included quantification of global m6A levels, analysis of PCNA messenger RNA (mRNA) stability via actinomycin D assay, and western blot for protein expression. Our findings demonstrate that STM2457 overcomes cisplatin resistance in OS by targeting the METTL3-m6A-PCNA axis, thereby disrupting a key DNA repair and cell survival pathway. Pharmacological inhibition of METTL3 represents a novel and promising epigenetic strategy for resensitizing chemoresistant OS, supporting its potential for future clinical development.