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    GENE:

    RMDN3 (Regulator Of Microtubule Dynamics 3)

    i
    Other names: RMDN3, Regulator Of Microtubule Dynamics 3, PTPIP51, FAM82A2, FAM82C, RMD3, Protein Tyrosine Phosphatase-Interacting Protein 51, Family With Sequence Similarity 82, Member A2, Regulator Of Microtubule Dynamics Protein 3, TCPTP-Interacting Protein 51, Cerebral Protein 10, FLJ10579, RMD-3, Family With Sequence Similarity 82, Member C, Microtubule-Associated Protein, Protein FAM82A2, Protein FAM82C, Ptpip51, HRMD-3
    Associations

    News

    Trials
    2ms
    RHOA regulates mitochondria-ER contact sites through modulation of the VAPB/PTPIP51 tether. (PubMed, Nat Commun)
    Furthermore, this regulatory mechanism is perturbed by disease alleles of RHOA, CUL3, and VAPB involved in cancer, hyperkalemia, and neurodegeneration, suggesting that MERCS may be affected in a range of pathological conditions. This study identifies RHOA as a regulator of mitochondria-ER communication, providing mechanistic insights into the dynamic remodeling of MERCS and potential therapeutic strategies for diseases linked to MERCS dysfunction.
    Journal
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    RHOA (Ras homolog family member A) • RMDN3 (Regulator Of Microtubule Dynamics 3)
    8ms
    SHBs Mitigates Sorafenib-Induced Apoptosis in Hepatocellular Carcinoma via Activation of RAF1/MEK/ERK Signaling Pathway. (PubMed, Cancer Sci)
    These findings suggest that SHBs prevents sorafenib-induced apoptosis in HCC cells by binding to PTPN1 and stimulating the formation of the PTPIP51/14-3-3β/RAF1 complex, thereby activating the RAF1/MEK/ERK signaling pathway. This mechanism provides insight into HBV-induced sorafenib resistance in HCC, highlighting SHBs as a potential target for overcoming treatment resistance in HBV-related HCC.
    Journal
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    RAF1 (Raf-1 Proto-Oncogene Serine/Threonine Kinase) • CASP3 (Caspase 3) • PTPN1 (Protein Tyrosine Phosphatase Non-Receptor Type 1) • RMDN3 (Regulator Of Microtubule Dynamics 3)
    |
    sorafenib
    12ms
    Association of inherited genetic variants with multiple primary melanoma. (PubMed, Cancer Epidemiol Biomarkers Prev)
    Our findings provide additional evidence that these loci are associated with melanoma risk and estimate the magnitude of their genetic effect on subsequent (multiple) primary melanoma risk.
    Journal • PARP Biomarker
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    CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • TERT (Telomerase Reverse Transcriptase) • MTAP (Methylthioadenosine Phosphorylase) • CDKN2B (Cyclin Dependent Kinase Inhibitor 2B) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • KLF4 (Kruppel-like factor 4) • TYRP1 (Tyrosinase Related Protein 1) • CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) • RMDN3 (Regulator Of Microtubule Dynamics 3)
    2years
    Cholesterol induction in CD8 T cell exhaustion in colorectal cancer via the regulation of endoplasmic reticulum-mitochondria contact sites. (PubMed, Cancer Immunol Immunother)
    High cholesterol regulated the ERS-ERMC-mitophagy axis to induce the exhaustion of CD8 T cells in CRC.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    ER (Estrogen receptor) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • BAP1 (BRCA1 Associated Protein 1) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CD69 (CD69 Molecule) • IL2 (Interleukin 2) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • ANXA5 (Annexin A5) • HSP90AB1 (Heat Shock Protein 90 Alpha Family Class B Member 1) • HSPA9 (Heat Shock Protein Family A (Hsp70) Member ) • MFN2 (Mitofusin 2) • RMDN3 (Regulator Of Microtubule Dynamics 3) • VDAC1 (Voltage Dependent Anion Channel 1)
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    IL2 expression
    almost4years
    PTPIP51 inhibits non-small-cell lung cancer by promoting PTEN-mediated EGFR degradation. (PubMed, Life Sci)
    The efficacy of the EGFR inhibitor gefitinib improves in combination with PTPIP51 to accelerate apoptosis and inhibit NSCLC growth in vivo and in vitro...This subsequently induces ubiquitylation of EGFR and its degradation via lysosomes. Therefore, PTPIP51 acts as a tumor suppressor in NSCLC by inducing PTEN phosphorylation and by promoting EGFR degradation.
    Journal
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    EGFR (Epidermal growth factor receptor) • PTEN (Phosphatase and tensin homolog) • RMDN3 (Regulator Of Microtubule Dynamics 3)
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    gefitinib