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    BIOMARKER:

    RIPK2 overexpression

    i
    Other names: RIPK2, Receptor Interacting Serine/Threonine Kinase 2, CARDIAK, Receptor-Interacting Serine/Threonine-Protein Kinase 2, CARD-Containing IL-1 Beta ICE-Kinase, Receptor-Interacting Protein 2, Tyrosine-Protein Kinase RIPK2, CARD3, Receptor-Interacting Protein (RIP)-Like Interacting Caspase-Like Apoptosis Regulatory Protein (CLARP) Kinase, CARD-Containing Interleukin-1 Beta-Converting Enzyme (ICE)-Associated Kinase, CARD-Containing Interleukin-1 Beta-Converting Enzyme-Associated Kinase, Receptor-Int
    Entrez ID:
    8767
    over1year
    RIPK2 and lysosomal pathway: Unveiling a new mechanism for lung cancer metastasis. (PubMed, Transl Oncol)
    This study reveals for the first time that RIPK2 promotes lung cancer metastasis by inhibiting LAMP2 expression, thereby suppressing the lysosomal pathway and altering the tumor microenvironment. In the future, targeted therapy against RIPK2 and LAMP2 may become an effective means to inhibit lung cancer metastasis.
    Journal
    |
    RIPK2 (Receptor Interacting Serine/Threonine Kinase 2) • LAMP2 (Lysosomal Associated Membrane Protein 2)
    |
    RIPK2 overexpression
    over2years
    RIPK2 promotes the progression of colon cancer by regulating BIRC3-mediated ubiquitination of IKBKG. (PubMed, Exp Cell Res)
    In addition, DLD-1 cells transfected with sh-RIPK2 or/and sh-BIRC3 were injected into mice to establish a tumor xenograft model, and we found that administration of sh-RIPK2 or sh-BIRC3 impeded the growth of xenograft tumors in vivo, and co-administration displayed a better inhibitory effect. In general, RIPK2 promotes the progression of colon cancer by promoting BIRC3-mediated ubiquitination of IKBKG and activating the NF-κB signaling pathway.
    Journal
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    BIRC3 (Baculoviral IAP repeat containing 3) • RIPK2 (Receptor Interacting Serine/Threonine Kinase 2)
    |
    RIPK2 overexpression