^
    3d
    A Phase 2b Clinical Study of JDB0131 Benzenesulfonate Tablets (clinicaltrials.gov)
    P2, N=60, Recruiting, WestVac Biopharma Co., Ltd. | Not yet recruiting --> Recruiting
    Enrollment open
    |
    rifampicin
    4d
    The efficacy and complications of rifampin-combined antibiotic therapy for staphylococcal periprosthetic joint infections: A multicenter, randomized controlled trial (ChiCTR2500114844)
    P=N/A, N=428, Not yet recruiting, The First Affiliated Hospital of Fujian Medical University; The First Affiliated Hospital of Fujian Medical University
    New trial
    |
    rifampicin
    6d
    A Study Evaluating the Effects of Itraconazole or Rifampin on the Pharmacokinetic Characteristics of Rocbrutinib Tablet (clinicaltrials.gov)
    P1, N=28, Not yet recruiting, Guangzhou Lupeng Pharmaceutical Company LTD.
    New P1 trial
    |
    itraconazole • rifampicin • rocbrutinib (LP-168)
    11d
    ToxZid: Therapeutic Drug Monitoring for Linezolid in the Treatment of Rifampin-resistant Tuberculosis (clinicaltrials.gov)
    P=N/A, N=280, Recruiting, Albert Einstein College of Medicine | Not yet recruiting --> Recruiting | Trial completion date: Sep 2029 --> Dec 2029 | Trial primary completion date: Mar 2029 --> Jun 2029
    Enrollment open • Trial completion date • Trial primary completion date
    |
    rifampicin
    12d
    SIM0270-104: An Open-Label Drug Interaction Clinical Study to Evaluate Itraconazole, Rifampin, Midazolam and SIM0270 in Chinese Healthy Adult Participants (clinicaltrials.gov)
    P1, N=60, Recruiting, Jiangsu Simcere Pharmaceutical Co., Ltd.
    New P1 trial
    |
    SCR-6852 • itraconazole • midazolam hydrochloride • rifampicin
    13d
    PORT: Pragmatic Optimized Rifampicin Trial (clinicaltrials.gov)
    P3, N=164, Recruiting, Radboud University Medical Center | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
    |
    rifampicin
    19d
    RIFREE: Rifampin-free Regimen Versus Rifampin-containing Regimen in the Treatment of Staphylococcal Prosthetic Valve Endocarditis (clinicaltrials.gov)
    P3, N=422, Not yet recruiting, Nantes University Hospital
    New P3 trial • Head-to-Head
    |
    rifampicin
    25d
    VA INTREPID: Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (clinicaltrials.gov)
    P4, N=843, Completed, VA Office of Research and Development | Active, not recruiting --> Completed
    Trial completion
    |
    rifampicin
    25d
    Drug-drug Interaction Study of Rifampin and Anaprazole Sodium (clinicaltrials.gov)
    P4, N=24, Not yet recruiting, Xuanzhu Biopharmaceutical Co., Ltd.
    New P4 trial
    |
    rifampicin
    26d
    Effect of Bupleuri Radix-Paeoniae Radix Albae combination on HMGB1/RAGE/NF-κB signaling pathway in rats with cholestatic hepatitis (PubMed, Zhongguo Zhong Yao Za Zhi)
    To explore the effect of the combination of Bupleuri Radix and Paeoniae Radix Alba on the high mobility group box-1 protein(HMGB1)/receptor for advanced glycation end-products(RAGE)/nuclear factor-κB(NF-κB) signaling pathway in rats with cholestatic hepatitis induced by rifampicin(RFP). Forty-two male SD rats were randomly divided into the normal group, the Bupleuri Radix-Paeoniae Radix Alba group(C-B group), the RFP group, the ursodeoxycholic acid(UDCA)+RFP group(UDCA+RFP group), the Bupleuri Radix+RFP group(C+RFP group), the Paeoniae Radix Alba+RFP group(B+RFP group), and the Bupleuri Radix-Paeoniae Radix Alba+RFP group(C-B+RFP group)...Compared with the C-B+RFP group, the ALT activity and the protein expression levels of HMGB1, RAGE, IL-6, and GRP78 were significantly higher in the C+RFP and the B+RFP groups. In conclusion, the combination of Bupleuri Radix and Paeoniae Radix Alba alleviates endoplasmic reticulum stress through the HMGB1/RAGE/NF-κB signaling pathway and reduces inflammatory responses, thereby exerting hepatoprotective effects.
    Preclinical • Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • HMGB1 (High Mobility Group Box 1) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • IL1B (Interleukin 1, beta)
    |
    rifampicin
    28d
    P-RIF: Precision Rifampin Trial for Personalized Dosing (clinicaltrials.gov)
    P1, N=200, Recruiting, University of Virginia | Not yet recruiting --> Recruiting
    Enrollment open
    |
    rifampicin
    1m
    Rifampin-combined Antibiotic Therapy for Staphylococcal PJI (clinicaltrials.gov)
    P=N/A, N=428, Recruiting, First Affiliated Hospital of Fujian Medical University
    New trial
    |
    rifampicin