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    BIOMARKER:

    RHOA L57V

    i
    Other names: RHOA, Ras homolog family member A, ARH12, ARHA, Rho12, RhoA, RHOH12, Rho cDNA clone 12, Transforming protein RhoA, H12
    Entrez ID:
    387
    Related biomarkers:
    Mutation
    11ms
    RHOA drivers take alternate routes in gastric cancer. (PubMed, Sci Signal)
    Having previously characterized the Y42C RHOA mutation in gastric cancer, in this issue of Science Signaling, Schaefer et al. take on the slightly less common L57V mutation and find that individual RHOA mutations can have different and unpredictable signaling outcomes.
    Review • Journal
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    RHOA (Ras homolog family member A)
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    RHOA L57V
    11ms
    RHOA drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling. (PubMed, Sci Signal)
    Both RHOA mutants stimulated the transcriptional co-activator YAP1 through actin dynamics to promote DGC progression; however, RHOA additionally did so by activating the kinases IGF1R and PAK1, distinct from the FAK-mediated mechanism induced by RHOA. Our results reveal that RHOA and RHOA drive the development of DGC through distinct biochemical and signaling mechanisms.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • CDH1 (Cadherin 1) • YAP1 (Yes associated protein 1) • RHOA (Ras homolog family member A)
    |
    KRAS mutation • CDH1 deletion • CDH1 expression • RHOA L57V • RHOA mutation