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GENE:

RGS2 (Regulator Of G Protein Signaling 2)

News alerts, weekly reports and conference planners

28d

The role of 5-methylcytosine regulator-related genes in diagnostic and immune regulatory functions in atherosclerosis. (PubMed, Front Immunol)

Five potential diagnostic biomarkers for AS-MCL1, F13A1, RGS2, TLR8, and TAGAP-were identified. In addition, the m5C regulator NSUN3 plays a critical role in macrophage function, providing experimental evidence that may support the diagnosis and treatment of AS.

28 days ago

Journal • IO biomarker

MCL1 (Myeloid cell leukemia 1) • TLR8 (Toll Like Receptor 8) • F13A1 (Coagulation Factor XIII A Chain) • RGS2 (Regulator Of G Protein Signaling 2) • NSUN5 (NOP2/Sun RNA Methyltransferase 5)

Cross-Regional Transcriptome Data Reveal Transcriptional Abnormalities Associated with Lung Adenocarcinoma. (PubMed, Rep Biochem Mol Biol)

Our findings suggest that the expression levels of serglycin, ILK, ESD, and PLPD1 may play a significant role in the development of LAC. This information can be valuable for identifying potential treatment targets for lung cancer.

1 month ago

Journal

CD123 (Interleukin 3 Receptor Subunit Alpha) • SPARC (Secreted Protein Acidic And Cysteine Rich) • VIM (Vimentin) • IL3RA (Interleukin 3 Receptor Subunit Alpha) • KRT19 (Keratin 19) • AQP1 (Aquaporin 1) • BST1 (Bone Marrow Stromal Cell Antigen 1) • COL3A1 (Collagen Type III Alpha 1 Chain) • SMAD7 (SMAD Family Member 7) • TAGLN (Transgelin) • ADH1B (Alcohol Dehydrogenase 1B (Class I), Beta Polypeptide) • AIMP2 (Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 2) • AKAP12 (A-Kinase Anchoring Protein 12) • RGS2 (Regulator Of G Protein Signaling 2) • NCOA1 (Nuclear Receptor Coactivator 1)

5ms

Usenamine A, an RGS2 inhibitor, exerts anti-NSCLC activity and enhances cytotoxicity of gemcitabine by inducing ER stress and Notch1-mediated autophagy. (PubMed, Bioorg Chem)

Additionally, combined therapy with UD32-3 and gemcitabine exerted synergistic anti-NSCLC activity. Our findings suggest that RGS2 is a promising therapeutic target for the treatment of NSCLC, and combined therapy with UD32-3 and gemcitabine might be an alternative therapeutic strategy for certain NSCLC patients.

5 months ago

Journal

NOTCH1 (Notch 1) • RGS2 (Regulator Of G Protein Signaling 2)

gemcitabine

7ms

Regulator of G-protein signaling 2 as a Suppressor of Sphingosine-1-phosphate 2- and 3-mediated Signaling in Colon Cancer Cells. (PubMed, J Biol Chem)

In contrast, RGS1 failed to inhibit S1P2- and S1P3-mediated Gα signaling, as well as downstream effects such as enhanced cell migration and cancer-associated gene expression. Our findings show that RGS2 suppresses S1P2- and S1P3-mediated cancer-associated cellular phenotypes by interacting with these receptors and inhibiting Gα-mediated signaling.

7 months ago

Journal

RGS2 (Regulator Of G Protein Signaling 2)

7ms

An integrated approach for key gene selection and cancer phenotype classification: Improving diagnosis and prediction. (PubMed, Comput Biol Med)

Moreover, Gene-TF and Gene-miRNA network analyses highlighted critical regulators, including TFs like CYR61, SMAD4, SOX2, TP63, and AR, along with miRNAs such as hsa-let-7b-5p, hsa-miR-34a-5p, hsa-let-7a-5p, hsa-let-7c-5p, and hsa-miR-16-5p, underscoring the functional impact of the selected features. In conclusion, the proposed approach effectively generates a streamlined set of optimal features, providing valuable biological insights and laying the groundwork for more accurate and effective tools in cancer diagnosis and prediction.

7 months ago

Journal

SMAD4 (SMAD family member 4) • SOX2 • MIR34A (MicroRNA 34a-5p) • CELF2 (CUGBP Elav-Like Family Member 2) • TP63 (Tumor protein 63) • Let-7c (MicroRNA Let-7c) • MIR16 (MicroRNA 16) • CCN1 (Cellular Communication Network Factor 1) • EFEMP1 (EGF Containing Fibulin Extracellular Matrix Protein 1) • MIRLET7B (MicroRNA Let-7b) • RGS2 (Regulator Of G Protein Signaling 2)

7ms

Unveiling the mechanisms of CEBPD-orchestrated TAM polarization through RGS2/PAR2 pathway and its impact on ICB efficacy in clear cell renal cell carcinoma. (PubMed, J Immunother Cancer)

This study revealed CEBPD regulated TAM polarization via the CEBPD/RGS2/PAR2 axis. Targeting CEBPD may be a potential approach and a complementary strategy to ICB therapies in ccRCC.

7 months ago

Journal • IO biomarker

CEBPA (CCAAT Enhancer Binding Protein Alpha) • RGS2 (Regulator Of G Protein Signaling 2)

8ms

Personalized Neoantigen Vaccine plus Regorafenib Increases Rgs2⁺CD8⁺ T Cells Infiltration and Reprograms the Tumor Microenvironment in Microsatellite Stable Colorectal Cancer Liver Metastases. (PubMed, Adv Sci (Weinh))

These Rgs2⁺CD8⁺ T cells, enriched for neoantigen-specific T cells, demonstrated potent tumor-killing capabilities in both mouse models and patient-derived organoids. The findings establish RegoNeo as a promising personalized immunotherapy that reprograms the immunosuppressive tumor microenvironment by increasing Rgs2⁺CD8⁺ T cell infiltration, highlighting both the treatment approach and this specific T cell subset as potential therapeutic targets for MSS-CRLM patients.

8 months ago

Journal • Tumor mutational burden • IO biomarker

TMB (Tumor Mutational Burden) • CD8 (cluster of differentiation 8) • RGS2 (Regulator Of G Protein Signaling 2)

TMB-L

Stivarga (regorafenib)

8ms

Exploration on the potential predictive value of regulator of G-protein signaling 2 in the efficacy of concurrent chemoradiotherapy on cervical squamous cell carcinoma. (PubMed, Cytojournal)

Immune cell subsets from donors and specific cytokines were evaluated, and the biological functions of CESC cells following cisplatin treatment or coculture with M2 macrophages were explored...This study interpreted and explored the possible predictive values of RGS2 in the efficacy of CCRT in CESC. It may provide other insights for the management of CESC.

8 months ago

Journal

CD8 (cluster of differentiation 8) • CD4 (CD4 Molecule) • IL10 (Interleukin 10) • IL4 (Interleukin 4) • RGS2 (Regulator Of G Protein Signaling 2)

cisplatin

9ms

Targeting BATF2-RGS2 axis reduces T-cell exhaustion and restores anti-tumor immunity. (PubMed, Mol Cancer)

RGS2, regulated by BATF2, plays a critical role in driving T cell exhaustion and tumor immune evasion in LC. Targeting the BATF2-RGS2 axis may enhance the effectiveness of immunotherapy by reversing T cell exhaustion and improving anti-tumor immunity.

9 months ago

Journal • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • CXCL13 (Chemokine (C-X-C motif) ligand 13) • RGS2 (Regulator Of G Protein Signaling 2)

9ms

Bulk and single-cell RNA sequencing identify prognostic signatures related to FGFBP2+ NK cell in hepatocellular carcinoma. (PubMed, PeerJ)

FTL and PTP4A2 silencing could suppress the proliferation, migration and invasion abilities of HCC cells. This study identified eight prognostic gene signatures related to FGFBP2+ NK cell in HCC, which may serve as potential therapeutic targets for HCC.

9 months ago

Journal • IO biomarker

GZMH (Granzyme H) • CDKN2D (Cyclin Dependent Kinase Inhibitor 2D) • RGS2 (Regulator Of G Protein Signaling 2)

9ms

Targeting Tumor Differentiation Grade-related Genes Prognostic Signature Including COL5A1 Based on Single-cell RNA-seq in Gastric Cancer. (PubMed, Int J Med Sci)

Finally, the hub gene COL5A1 was obviously correlated with B cells memory, dendritic cells activated, macrophages M0, macrophages M2, plasma cells, T cells follicular helper in GC. This study reveals a novel tumor differentiation grade-related genes signature, and COL5A1 represents a promising biomarker in GC.

9 months ago

Journal

CXCR4 (Chemokine (C-X-C motif) receptor 4) • COL1A1 (Collagen Type I Alpha 1 Chain) • MUC13 (Mucin 13) • MAGEA3 (MAGE Family Member A3) • COL5A1 (Collagen Type V Alpha 1 Chain) • RGS2 (Regulator Of G Protein Signaling 2)