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    GENE:

    RFC3 (Replication Factor C Subunit 3)

    i
    Other names: RFC3, Replication Factor C Subunit 3, RFC38, A1 38 KDa Subunit, Replication Factor C (Activator 1) 3, 38kDa, Replication Factor C 38 KDa Subunit, Activator 1 38 KDa Subunit, Activator 1 Subunit 3, RF-C 38 KDa Subunit, RFC, 38 KD Subunit, MGC5276, Replication Factor C (Activator 1) 3 (38kD)
    5ms
    Prognostic significance and pathogenesis of RFC3 gene expression in diffuse large B-cell lymphoma. (PubMed, PeerJ)
    RFC3 may serve as a novel prognostic biomarker and a potential therapeutic target for DLBCL. Further investigations into the mechanisms underlying RFC3 dysregulation may provide important insights for future diagnostic and therapeutic strategies.
    Journal • IO biomarker
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    RFC3 (Replication Factor C Subunit 3)
    7ms
    Identification of Prognostic Biomarkers in Gene Expression Profile of Neuroblastoma Via Machine Learning. (PubMed, Pediatr Discov)
    Additionally, our findings revealed that these biomarkers are correlated to chemotherapy drugs, such as vincristine and cyclophosphamide. Furthermore, drug sensitivity analyses identified several candidate drugs, such as dactinomycin, bortezomib, docetaxel, and sepantronium bromide, that may hold therapeutic potential for NB treatment. This study offers novel insights to underlying NB prognosis and therapeutic targets and provides a foundation for developing personalized treatment strategies to improve clinical outcomes.
    Journal • Gene Expression Profile • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • RAD51 (RAD51 Homolog A) • AURKA (Aurora kinase A) • PLK1 (Polo Like Kinase 1) • CHEK1 (Checkpoint kinase 1) • CCNA2 (Cyclin A2) • RFC3 (Replication Factor C Subunit 3) • E2F1 (E2F transcription factor 1) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1)
    |
    docetaxel • bortezomib • cyclophosphamide • vincristine • dactinomycin • sepantronium bromide (PC-002)
    almost2years
    RFC3 drives the proliferation, migration, invasion and angiogenesis of colorectal cancer cells by binding KIF14. (PubMed, Exp Ther Med)
    Moreover, KIF14 upregulation reversed the effects of RFC3 depletion on the aggressive cellular behaviors in CRC. In conclusion, RFC3 might interact with KIF14 to function as a contributor to the malignant development of CRC.
    Journal
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    RFC3 (Replication Factor C Subunit 3)
    2years
    Abnormal activation of RFC3, A YAP1/TEAD downstream target, promotes gastric cancer progression. (PubMed, Int J Clin Oncol)
    RFC3 was transcriptional activated by the YAP1/TEAD signaling pathway, thus promoting GC progression. RFC3 may be a promising therapeutic target for GC.
    Journal
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    YAP1 (Yes associated protein 1) • RFC3 (Replication Factor C Subunit 3)