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3ms
Nano-Pulse Stimulation Treatment Inhibits Pan02 Murine Pancreatic Tumor Growth and Induces a Long-Term Adaptive Immune Response with Abscopal Effects When Combined with Immune-Enhancing Agents. (PubMed, Bioelectricity)
NPS in combination with the adjuvant and TLR agonist, resiquimod (RES), was the optimal treatment regimen for both eliminating a primary Pan02 tumor as well as inhibiting growth of a Pan02 cell rechallenge tumor...NPS plus RES was the most effective at both eliminating a primary tumor and inhibiting a rechallenge tumor. NPS treatment followed by injection of aOX40 was the most effective at inhibiting the growth of an untreated abscopal tumor.
Preclinical • Journal
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CD8 (cluster of differentiation 8)
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resiquimod (STM-416)
4ms
A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer (clinicaltrials.gov)
P1/2, N=75, Recruiting, SURGE Therapeutics | Trial completion date: Sep 2024 --> Dec 2025 | Trial primary completion date: Jun 2024 --> Dec 2025
Trial completion date • Trial primary completion date
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resiquimod (STM-416)
6ms
Maternal immune activation with toll-like receptor 7 agonist during mid-gestation alters juvenile and adult developmental milestones and behavior. (PubMed, J Neuroendocrinol)
The goal of this study was to determine sex-dependent aspects of MIA using a TLR7/8 agonist, Resiquimod (RQ), on neurodevelopment...This study provides support for sex-dependent influences of fetal antecedents for altered brain development and behavioral outputs that could be indicative of increased susceptibility for adult disorders through immune mechanisms. Future studies are needed to determine neural cellular and molecular mechanisms for such programming effects.
Journal
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IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL10 (Interleukin 10) • IL17A (Interleukin 17A)
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resiquimod (STM-416)
10ms
Polymeric nanocapsules loaded with poly(I:C) and resiquimod to reprogram tumor-associated macrophages for the treatment of solid tumors. (PubMed, Front Immunol)
While no significant alterations were observed in T cell numbers (CD8, CD4 or Treg), TAM-reprogramming in treated mice was confirmed by the relative decrease of interstitial versus alveolar macrophages, having higher CD86 expression but lower CD206 and Arg1 expression in the same cells, in treated mice. Mannose-HA-protamine-NCs loaded with poly(I:C)+R848 successfully reprogram TAMs in vivo, and reduce tumor progression and metastasis spread in mouse tumors.
Journal • IO biomarker
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CD8 (cluster of differentiation 8) • CXCL10 (Chemokine (C-X-C motif) ligand 10) • CD4 (CD4 Molecule) • MRC1 (Mannose Receptor C-Type 1) • CD86 (CD86 Molecule)
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MRC1 expression
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resiquimod (STM-416)
over1year
A Study of STM-416 Administered to Patients Undergoing TURBT for Recurrent Bladder Cancer (clinicaltrials.gov)
P1/2, N=75, Recruiting, SURGE Therapeutics | Not yet recruiting --> Recruiting | Initiation date: Mar 2023 --> Jun 2023
Enrollment open • Trial initiation date
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resiquimod (STM-416)
over1year
Degradable hydrogel for sustained localized delivery of anti-tumor drugs. (PubMed, J Pharm Sci)
Resiquimod, a TLR7/8 agonist, and axitinib, a vascular endothelial growth factor tyrosine kinase inhibitor, were chosen as anti-cancer drugs. In summary, TransCon Hydrogel technology allows localized sustained-release drug delivery for cancer therapy enabling high local drug concentrations while at the same time ensuring low systemic drug exposure over weeks with a single injection, which may improve the therapeutic index and improve efficacy, while minimizing systemic adverse events. A hydrogel prodrug of resiquimod, TransCon TLR7/8 agonist, is currently being investigated in clinical trials of patients with solid tumors (NCT04799054).
Journal
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Inlyta (axitinib) • resiquimod (STM-416) • resiquimod SR (TransCon TLR7/8 Agonist)
over1year
Combined administration of poly(I:C) and resiquimod triggers effective antitumoral response in mouse models of pancreatic adenocarcinoma (AACR 2023)
In conclusion, our work clearly demonstrates that pIC+R848 are an effective treatment for PDAC when injected intratumorally and that this activity strongly relies on IFN-γ and adaptive immunity. Further investigations are ongoing to assess their potential in orthotopic models using different routes of administration, in a setting closer to the real clinical situation.
Preclinical
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CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • CSF1R (Colony stimulating factor 1 receptor) • TLR3 (Toll Like Receptor 3) • TLR7 (Toll Like Receptor 7)
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resiquimod (STM-416)
over1year
Ionic Liquid-Based Transcutaneous Peptide Antitumor Vaccine: Therapeutic Effect in a Mouse Tumor Model. (PubMed, AAPS J)
ILs successfully increased the in vitro skin permeability of a peptide from Wilms tumor 1 (WT1), one of the more promising cancer antigens, plus or minus an adjuvant, resiquimod (R848), a toll-like receptor 7 agonist...Furthermore, sequential immunization with IL-based formulations was applicable to different types of peptides and cancer models without induction of skin irritation. IL-based transcutaneous delivery of cancer antigen-derived peptides and adjuvants, either alone or together, could be a novel approach to needle-free cancer therapeutic vaccines.
Preclinical • Journal
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WT1 (WT1 Transcription Factor)
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resiquimod (STM-416)