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    BIOMARKER:

    RELN mutation

    i
    Other names: RELN, Reelin, PRO1598, RL, ETL7, LIS2
    Entrez ID:
    5649
    almost2years
    Whole-exome sequencing has revealed novel genetic characteristics in intracranial germ cell tumours in the Chinese. (PubMed, Histopathology)
    This study indicated that Chinese IGCT patients may have distinct genetic characteristics and identified several possible genetic alterations that have the potential to become prognostic biomarkers of NGGCT patients.
    Journal
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    NF1 (Neurofibromin 1) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • TFE3 (Transcription Factor Binding To IGHM Enhancer 3) • PDGFA (Platelet Derived Growth Factor Subunit A) • RELN (Reelin) • SYNE1 (Spectrin Repeat Containing Nuclear Envelope Protein 1) • RAC2 (Rac Family Small GTPase 2)
    |
    NF1 mutation • RELN mutation
    over2years
    Characteristics of molecular genetic mutations and their correlation with prognosis in adolescent and adult patients with ALL. (PubMed, Oncology)
     The distribution of gene mutations and the co-occurrence and repulsion of mutant genes in patients with ALL were closely related to the immunophenotype of the patients. The number of mutations ≥5 and the RELN mutation were significantly associated with poor prognosis in adolescent and adult patients with ALL.
    Journal
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    FLT3 (Fms-related tyrosine kinase 3) • PTEN (Phosphatase and tensin homolog) • NOTCH1 (Notch 1) • RUNX1 (RUNX Family Transcription Factor 1) • TET2 (Tet Methylcytosine Dioxygenase 2) • KMT2D (Lysine Methyltransferase 2D) • FAT1 (FAT atypical cadherin 1) • JAK1 (Janus Kinase 1) • JAK3 (Janus Kinase 3) • PHF6 (PHD Finger Protein 6) • RELN (Reelin)
    |
    PTEN mutation • NOTCH1 mutation • TET2 mutation • KMT2D mutation • JAK3 mutation • PHF6 mutation • RELN mutation
    3years
    Identification and Validation of RELN Mutation as a Response Indicator for Immune Checkpoint Inhibitor Therapy in Melanoma and Non-Small Cell Lung Cancer. (PubMed, Cells)
    Further exploration demonstrated that favorable immunocyte infiltration and immune response signaling pathways were found in patients with RELN mutations. In this study, RELN mutations were identified to connect with a better immune microenvironment and an improved ICI efficacy in melanoma and NSCLC, which provides a potential biomarker for immunological feature evaluation and immunotherapeutic outcome prediction at the molecular level.
    Journal • Checkpoint inhibition • IO biomarker
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    RELN (Reelin)
    |
    RELN mutation
    3years
    Targeted Next-Generation Sequencing Identifies Additional Mutations Other than BCR∷ABL in Chronic Myeloid Leukemia Patients: A Chinese Monocentric Retrospective Study. (PubMed, Cancers (Basel))
    In the analysis of clinical characteristics, hemoglobin concentration (HB) and MMR were independent factors for deep molecular response (DMR), and initial 2GTKI therapy was better than 1GTKI in the achievement of molecular response. For the scoring system, we found the ELTS score was the best for predicting the efficacy of TKI therapy and the Socal score was the best for predicting mutations other than BCR∷ABL.
    Retrospective data • Journal • Next-generation sequencing
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    ABL1 (ABL proto-oncogene 1) • ASXL1 (ASXL Transcriptional Regulator 1) • NOTCH3 (Notch Receptor 3) • RELN (Reelin)
    |
    ASXL1 mutation • NOTCH3 mutation • RELN mutation
    3years
    Targeted Next-Generation Sequencing Identifies Additional Mutations Other Than BCR-ABL in Chronic Myeloid Leukemia Patients: A Chinese Monocentric Retrospective Study (ASH 2022)
    79 Qingchun Road. Hangzhou, Zhejiang, PR China.
    Retrospective data • Next-generation sequencing
    |
    ABL1 (ABL proto-oncogene 1) • BCR (BCR Activator Of RhoGEF And GTPase) • DNMT3A (DNA methyltransferase 1) • ASXL1 (ASXL Transcriptional Regulator 1) • KMT2C (Lysine Methyltransferase 2C) • NOTCH3 (Notch Receptor 3) • RELN (Reelin)
    |
    ATM mutation • ASXL1 mutation • RELN mutation