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    CANCER:

    Rectal Cancer

    Related cancers:
    20h
    Neoadjuvant mFOLFOX6 Chemotherapy Combined With Anti-PD-1 Therapy in MSS/pMMR Locally Advanced Rectal Cancer (FIRM02 Study) (clinicaltrials.gov)
    P2, N=128, Not yet recruiting, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
    New P2 trial • pMMR
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    MLH1 (MutL homolog 1) • MSH6 (MutS homolog 6) • MSH2 (MutS Homolog 2)
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    5-fluorouracil • oxaliplatin • leucovorin calcium • Hetronifly (serplulimab)
    2d
    A Study of Tucatinib and Trastuzumab in People With Rectal Cancer (clinicaltrials.gov)
    P2, N=37, Recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Dec 2025 --> Dec 2026 | Trial primary completion date: Dec 2025 --> Dec 2026
    Trial completion date • Trial primary completion date
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    HER-2 (Human epidermal growth factor receptor 2) • KRAS (KRAS proto-oncogene GTPase)
    |
    HER-2 positive • HER-2 overexpression • HER-2 amplification • RAS wild-type • HER-2 positive + HER-2 overexpression • HER-2 positive + RAS wild-type
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    Herceptin (trastuzumab) • Tukysa (tucatinib)
    3d
    A retrospective single-center clinical study on the impact of neoadjuvant therapy on intestinal fistula formation after colorectal cancer surgery. (ChiCTR2600117650)
    P=N/A, N=1000, Not yet recruiting, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical College, Huazhong University o
    New trial
    3d
    Central Mechanisms Underlying the Influence of Genetic Polymorphisms on Individual Differences in Postoperative Analgesia Following Hydrocodone Bitartrate Injection: An EEG and fMRI Analysis (ChiCTR2600117536)
    P=N/A, N=60, Not yet recruiting, Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology; Union Hospital, Tongji Medical Co
    New trial
    3d
    To investigate the efficacy and safety of irinotecan liposome combined with fluorouracil and oxaliplatin as neoadjuvant therapy for locally advanced rectal cancer (ChiCTR2600117281)
    P=N/A, N=34, Not yet recruiting, Tianjin Medical University General Hospital; Tianjin Medical University General Hospital
    New trial
    |
    BRAF (B-raf proto-oncogene)
    |
    BRAF mutation • RAS mutation
    |
    5-fluorouracil • leucovorin calcium
    3d
    Application and Exploration of Personalized ctDNA - MRD Detection Technology in Efficacy Prediction of Neoadjuvant Therapy for Rectal Cancer (ChiCTR2600116652)
    P=N/A, N=60, Not yet recruiting, Beijing Friendship Hospital, Capital Medical University; Beijing Friendship Hospital, Capital Medical University
    New trial
    3d
    Electroacupuncture to Prevent Urinary Retention after Laparoscopic Rectal Cancer Resection: A Prospective, Multicenter, Randomized Controlled Trial (ChiCTR2500115793)
    P=N/A, N=250, Not yet recruiting, West China Hospital, Sichuan University; West China Hospital, Sichuan University
    New trial
    3d
    Incidence and risk factors of postoperative complications assessed by the Clavien-Dindo classification after robotic radical surgery for rectal cancer (ChiCTR2500115501)
    P=N/A, N=923, Completed, The First Affiliated Hospital of Army Medical University; The First Affiliated Hospital of Army Medical University
    New trial
    3d
    Neoadjuvant FOLFOXIRI chemotherapy with or without camrelizumab in the treatment of locally advanced rectal cancer: a retrospective cohort study (ChiCTR2500114600)
    P=N/A, N=150, Not yet recruiting, Harbin medical university cancer hospital; Harbin medical university cancer hospital
    New trial
    |
    5-fluorouracil • AiRuiKa (camrelizumab) • oxaliplatin • irinotecan • leucovorin calcium
    3d
    Exploring the Impact of the Tumor Microenvironment on Rectal Cancer Diagnosis and Prognosis with Multi-Parameter MRI and AI for Intelligent Model Development (ChiCTR2500114373)
    P=N/A, N=500, Recruiting, The Sixth Affiliated Hospital of Sun Yat-sen University; The Sixth Affiliated Hospital of Sun Yat-sen University
    New trial
    3d
    Clinical study on the safety and efficacy of sintilimab combined with chemotherapy in neoadjuvant treatment of locally advanced rectal cancer (ChiCTR2500114358)
    P=N/A, N=41, Recruiting, The First Affiliated Hospital of Anhui Medical University; The First Affiliated Hospital of Anhui Medical University
    New trial
    |
    PD-L1 (Programmed death ligand 1)
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    PD-L1 expression
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    Tyvyt (sintilimab) • capecitabine • oxaliplatin
    3d
    Response-adapted total neoadjuvant therapy guided by induction chemotherapy in early- and intermediate-risk low rectal cancer: an observational study for watch-and-wait strategy (ChiCTR2500113437)
    P=N/A, N=60, Not yet recruiting, West China Hospital of Sichuan University; West China Hospital of Sichuan University
    New trial