Rectal Cancer

Neoadjuvant chemotherapy prior to laparoscopic radical resection for rectal cancer was associated with improved anus preservation, enhanced postoperative recovery, and greater biochemical and functional benefits without increasing major complication rates, although it was linked to higher hematologic adverse events and postoperative declines in immune cell counts.

Prior psoriasis treatments included ultraviolet B phototherapy, methotrexate, ciclosporin and acitretin. At cancer diagnosis, 10 patients (20%) were on tumour necrosis factor (TNF)-α inhibitors, 8 (16%) on interleukin (IL)-17 inhibitors, five (10%) on IL-12/23 inhibitors, 5 (10%) on IL-23 inhibitors, 6 (12%) on methotrexate, 2 (4%) on apremilast and 1 (2%) on ciclosporin...Multidisciplinary collaboration and shared decision making are essential. Clinicians should consider biologic therapies for patients with both malignancy and uncontrolled psoriasis, tailoring treatments to patient-specific factors and malignancy type.

Prior psoriasis treatments included ultraviolet B phototherapy, methotrexate, ciclosporin and acitretin. At cancer diagnosis, 10 patients (20%) were on tumour necrosis factor (TNF)-α inhibitors, eight (16%) on interleukin (IL)-17 inhibitors, five (10%) on IL-12/23 inhibitors, five (10%) on IL-23 inhibitors, six (12%) on methotrexate, two (4%) on apremilast and one (2%) on ciclosporin...Multidisciplinary collaboration and shared decision making are essential. Clinicians should consider biologic therapies for patients with both malignancy and uncontrolled psoriasis, tailoring treatments to patient-specific factors and malignancy type.

P3, N=382, Not yet recruiting, Sun Yat-sen University

Notably, in vitro functional assays of the less-reported gene SLC19A1 demonstrated its role in promoting LARC progression. This study offers new insights into the molecular mechanisms underlying LARC pathogenesis and identifies potential therapeutic targets.

An eight-gene CSC signature captures a stemness-linked G2/M program that generalizes across cohorts, relates to the microenvironment, and is therapeutically tractable via kinase targeting, providing a compact readout for risk stratification and preclinical screening.

Genes such as SYP show significant differential expression in both T2DM and RC and may play significant roles in the progression of T2DM and RC. Transcription factor analysis suggested that SP1 could regulate multiple hub genes. Molecular docking indicated that SP1 is a potential target for active components like stearic acid and EGCG in Ginkgo biloba, highlighting its potential as a therapeutic agent for T2DM and RC.

P=N/A, N=30, Recruiting, University of South Florida | Trial completion date: Jun 2025 --> Jun 2027 | Trial primary completion date: Dec 2024 --> Dec 2026

The observed toxicity was consistent with the known toxicity profile of immunotherapy and did not lead to discontinuation of therapy. Our case report highlights the need to test for predictive markers in patients with locoregionally advanced rectal cancer in order to identify specific subtypes of the disease that can be treated with immunotherapy with a high probability of achieving clinical complete remission, thereby avoiding potentially risky surgery.

P1, N=37, Recruiting, Fox Chase Cancer Center | Not yet recruiting --> Recruiting

P1, N=135, Active, not recruiting, Boehringer Ingelheim | Recruiting --> Active, not recruiting

P=N/A, N=3500, Completed, Northern Jiangsu People's Hospital