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    GENE:

    RECQL5 (RecQ Like Helicase 5)

    i
    Other names: RECQL5, RecQ Like Helicase 5, DNA Helicase RecQ-Like Type 5, ATP-Dependent DNA Helicase Q5, RecQ Protein-Like 5, RECQ5, RecQ Helicase-Like 5, RecQ Protein 5, RecQ5
    6ms
    Recql5-Deficient Mice as a Model for Studying Chromoanagenesis Phenomena. (PubMed, Methods Mol Biol)
    This chapter discusses the creation of CCR animal models, offering a new perspective for exploring the pathogenesis of chromosomal rearrangements. Recql5-mutant mice will prove to be a valuable tool for further genetic studies, potentially advancing our understanding of disease mechanisms and suggesting directions for future research.
    Preclinical • Journal
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    RECQL5 (RecQ Like Helicase 5)
    6ms
    RECQ5 mediates pre-rRNA processing in nucleolus. (PubMed, Nucleic Acids Res)
    Since both RECQ5 and ATR protect genomic stability in nucleolus, suppression of RECQ5 sensitizes tumor cells to the ATR inhibitor treatment. Collectively, this study reveals that RECQ5 plays a crucial role in pre-rRNA processing and ribosomal DNA (rDNA) stability.
    Journal
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    RECQL5 (RecQ Like Helicase 5)
    11ms
    Serum-Based Proteomic Approach to Identify Clinical Biomarkers of Radiation Exposure. (PubMed, Cancers (Basel))
    About 40% of the RMPs are involved in acute phase response, DNA repair, and inflammation; the key RMPs were ADCY1, HGF, MCEMP1, CHD4, RECQL5, MSH6, and ZNF224. This study identifies a panel of serum proteins that may reflect the radiation response, providing a valuable molecular fingerprint of IR exposure and paving the way for the development of sensitive and specific biomarkers for early detection and clinical management of IR-related injuries.
    Journal
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    MSH6 (MutS homolog 6) • RECQL5 (RecQ Like Helicase 5) • CHD4 (Chromodomain Helicase DNA Binding Protein 4)
    1year
    Exome-based cancer predisposition gene testing can provide a genetic diagnosis for individuals with heterogeneous tumor phenotypes. (PubMed, Eur J Hum Genet)
    In conclusion, our study indicates that exome-based cancer predisposition gene testing may aid in the identification of pathogenic variants in individuals who developed multiple primary tumors. Our findings demonstrate that individuals with gPVs in genes associated with cancer predisposition may present with a broad tumor spectrum.
    Journal
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    PTEN (Phosphatase and tensin homolog) • NF1 (Neurofibromin 1) • CHEK2 (Checkpoint kinase 2) • FANCM (FA Complementation Group M) • POT1 (Protection of telomeres 1) • RECQL5 (RecQ Like Helicase 5) • RECQL4( RecQ Like Helicase 4) • HOXB13 (Homeobox B13)
    1year
    Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers. (PubMed, Int J Cancer)
    In the nine whole-exome sequenced patients, eight harbored at least two candidate DNA repair/cell cycle/TGFβ signaling gene variants. The number of families is too small to provide evidence for individual variants but, considering the known role of DNA repair/cell cycle genes in CRC, the clustering of multiple deleterious variants in the present families suggests that these, perhaps jointly, contributed to CRC development in these families.
    Journal
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    CHEK2 (Checkpoint kinase 2) • FANCI (FA Complementation Group I) • RECQL5 (RecQ Like Helicase 5) • RRM2 (Ribonucleotide Reductase Regulatory Subunit M2) • RECQL (RecQ Like Helicase) • XRCC1 (X-Ray Repair Cross Complementing 1) • FAAP24 (FA Core Complex Associated Protein 24)
    almost2years
    A Recql5 mutant facilitates complex CRISPR/Cas9-mediated-chromosomal engineering in mouse zygotes. (PubMed, Genetics)
    Some of these structural features of individual chromosomal rearrangements use template switching and microhomology-mediated break-induced replication mechanisms and are reminiscent of the newly described phenomenon "chromoanasynthesis." These data show that Recql5-mutant mice could be a powerful tool to analyze the pathogenesis of CCRs (particularly chromoanasynthesis) whose underlying mechanisms are poorly understood. The Recql5 mutants generated in this study are to be deposited at key animal research facilities, thereby making them accessible for future research on CCRs.
    Preclinical • Journal
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    RECQL5 (RecQ Like Helicase 5)
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    RECQL5 mutation
    almost2years
    RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication. (PubMed, J Clin Invest)
    RNF4 deficiency also resulted in an accumulation of hyper-SUMOylated proteins in chromatin, including members of the SMC5/6 complex, which contributes to replication failure by a mechanism dependent on RAD51. These findings indicate that RNF4, which shows increased expression in multiple human tumor types, is a potential target for anti-cancer therapy, especially in tumors expressing c-myc.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • RAD51 (RAD51 Homolog A) • RECQL5 (RecQ Like Helicase 5)
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    MYC expression
    2years
    Mechanism of Antitumor Effects of Saffron in Human Prostate Cancer Cells. (PubMed, Nutrients)
    Collectively, our findings demonstrate the important mechanisms by which saffron mediates anti-tumor properties in prostate cancer. These findings suggest that the use of saffron supplements alongside standard treatment protocols may yield beneficial effects for individuals with prostate cancer.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • TNFA (Tumor Necrosis Factor-Alpha) • DNMT1 (DNA methyltransferase 1) • WRN (WRN RecQ Like Helicase) • DNMT3B (DNA Methyltransferase 3 Beta) • RECQL5 (RecQ Like Helicase 5) • HDAC3 (Histone Deacetylase 3) • COMT (Catechol-O-Methyltransferase) • MST1R (Macrophage Stimulating 1 Receptor)
    2years
    SUKSES-B2: Olaparib and Bevacizumab in Relapsed Small Cell Lung Cancer Subjects (clinicaltrials.gov)
    P2, N=25, Completed, Se-Hoon Lee | Recruiting --> Completed | Trial primary completion date: Jun 2023 --> Oct 2023
    Trial completion • Trial primary completion date • Combination therapy
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • SLFN11 (Schlafen Family Member 11) • BRCA (Breast cancer early onset) • RAD51 (RAD51 Homolog A) • RAD51B (RAD51 Paralog B) • RAD51C (RAD51 paralog C) • RAD50 (RAD50 Double Strand Break Repair Protein) • NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)) • RAD54L (DNA Repair And Recombination Protein RAD54) • WRN (WRN RecQ Like Helicase) • POU2F3 (POU Class 2 Homeobox 3) • RAD52 (RAD52 Homolog DNA Repair Protein) • RECQL5 (RecQ Like Helicase 5) • RECQL (RecQ Like Helicase) • RECQL4( RecQ Like Helicase 4) • RPA1 (Replication Protein A1)
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    BRCA2 mutation • BRCA1 mutation • RAD51C mutation • RAD51D mutation • RAD50 mutation • RAD51B mutation • BLM mutation • BRCA mutation • MRE11A mutation • RAD54L mutation • NBN mutation • RAD52 mutation • RECQL mutation • RECQL4 mutation • RECQL5 mutation
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    Avastin (bevacizumab) • Lynparza (olaparib)
    2years
    Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing the transcription and splicing of tumorigenesis-related genes. (PubMed, PeerJ)
    Overall, extensive transcriptome analysis of gene alternative splicing and expression levels was performed in cells transfected with FSCN1 short-interfering RNA. Our data provide global insights into the regulatory mechanisms associated with the roles of FSCN1 and its target genes in lung cancer.
    Journal
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    KRT7 (Keratin-7) • NCOR2 (Nuclear Receptor Corepressor 2) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • RECQL5 (RecQ Like Helicase 5) • FSCN1 (Fascin Actin-Bundling Protein 1) • PDE3A (Phosphodiesterase 3A) • ACTG1 (Actin Gamma 1) • NME4 (NME/NM23 Nucleoside Diphosphate Kinase 4) • NSD2 (Nuclear Receptor Binding SET Domain Protein 2) • WTAP (WT1 Associated Protein)
    over2years
    Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy. (PubMed, World J Gastrointest Surg)
    The polymorphism of the RECQL5 and TEP1 genes were associated with HRV during peritoneal lavage with distilled water after gastrectomy.
    Journal
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    RECQL5 (RecQ Like Helicase 5) • RECQL (RecQ Like Helicase)
    over2years
    Functional inhibition of RECQL5 helicase elicits non-homologous end joining response and sensitivity of breast cancers to PARP inhibitor. (PubMed, Int J Biochem Cell Biol)
    In the current investigation, we show that targeted inhibition of HR by stabilization of RAD51-RECQL5 complex by a pharmacological inhibitor of RECQL5 (4a; 1,3,4-oxadiazole derivative) in the presence of PARPi [talazoparib (BMN673)] leads to abolition of functional HR with uncontrolled activation of NHEJ repair...Moreover, functional inhibition of RECQL5 suppresses metastatic potential of breast cancer cells in response to PARPi. Together, we identified RECQL5 as a novel pharmacological target for expanding PARPi based treatment horizon for HR-proficient cancers.
    Journal • BRCA Biomarker • PARP Biomarker
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    BRCA (Breast cancer early onset) • RAD51 (RAD51 Homolog A) • RECQL5 (RecQ Like Helicase 5)
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    BRCA wild-type • BRCA mutation
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    Talzenna (talazoparib)