RDX (Radixin)

© 2026 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland

Overexpression of Ezrin also improved the rim formation in HeLa cells upon addition of a calcium ionophore. Thus, the ERM proteins appear to participate in a mechanism that links actin filaments to the nuclear envelope.

Here, ERM proteins are identified as modulators of erastin-induced ferroptosis...Notably, other pro-oxidants similarly attenuate ferroptosis at appropriate concentrations. Together, these results establish ERM proteins as regulators of ferroptosis and reveal an underappreciated group of ferroptosis inhibitors that engage ROS-NRF2-mediated redox-adaptation.

This mini review examines the contrasting roles of FAK in GBM and NF2-mutant meningiomas to underscore the importance of biological context in therapeutic decisions. We propose that NF2-mutant meningiomas represent a model for context-specific, synthetic lethal targeting, exemplifying a functional oncogenomics approach to precision oncology.

This review provides a comprehensive and uniquely alphabetized overview of Ezrin associations with a wide array of diseases, making it the first of its kind to catalog Ezrin biological relevance from A to Z. We examine its structural and biochemical characteristics, underscoring its potential as a diagnostic and prognostic biomarker, as well as an emerging therapeutic target. By addressing critical knowledge gaps, this review highlights Ezrin central role at the intersection of cancer biology, immunology, and neurotherapeutics.

The positively charged Lys-577, as well as the hydrophobic Ile-580 in the αD-helix, are pivotal for F-actin binding. Besides electrostatic interactions (Lys-577), Ile-580 appears to be crucial and might mediate the interaction with the hydrophobic cleft of G-actin.

However, the mechanistic role of layilin in most of these studies remains unexplored. This review outlines current insights into Layilin as a molecular hub that links hyaluronan signaling with integrin activity and cytoskeletal dynamics, highlighting its roles in homeostasis, pathogenesis, disease prognosis, and therapeutic intervention across diverse conditions.

The function of knockout aortic and mesenteric vessels was less impaired by Ang II, as reflected by less augmented contraction to norepinephrine and serotonin and preserved relaxation to acetylcholine and sodium nitroprusside...Ang II caused less proliferation (lower PCNA [proliferating cell nuclear antigen]) and less induction of senescence in knockout vessels. LRRC8A anion channels support VSMC inflammation and the associated vascular dysfunction, which impairs BP dipping in hypertension.

Taken together, these data suggest that the negatively controlled PDPN-ERM axis may act as a molecular factor controlling the development of entotic structures and cells with naturally low PDPN expression may be more liable to form entoses.

Our findings demonstrated a significant loss of spiral ganglion neurons, a slight increase of Schwann cells, and marked activation of cochlear macrophages in NF2-SWN cases. These findings indicate the contribution of cochlear macrophage-mediated inflammation and Schwann cell dysregulation in the pathophysiology of SNHL in NF2-SWN.

Our findings demonstrate that miR-204-5p functions as a tumor suppressor in breast cancer by targeting Ezrin and inhibiting the AKT pathway. This suggests a potential therapeutic role for miR-204-5p in the treatment of breast cancer.

Our findings indicate that c-Jun-activated HIF1A-AS2 acts as an oncogenic factor in CC by sponging miR-34b-5p to target radixin. These findings suggest that HIF1A-AS2 might be a viable and promising therapeutic target for cervical cancer treatment.