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DRUG:

RC1012

i
Other names: RC1012
Associations
Trials
Company:
Ruichuang Bio
Drug class:
Cell therapy
Associations
Trials
12ms
Increase of Dnts Correlated with Clinic Outcome after Allogeneic DNT Cells Infusion in r/r AML Patients (ASH 2023)
Here, we reported our ongoing phase I clinical trial of RC1012 injection (allogeneic DNT cells) in patients with r/r AML (NCT05471323)...After lymphodepleting chemotherapy with fludarabine and cyclophosphamide, each patient received three infusions of HLA-mismatched DNT cells at 1... Allogeneic DNTs therapy are safe in clinical treatment and can reduce tumor burden after infusion with the increase of patient's DNT cells in complete remission and partial remission patients. These findings warrant the allogeneic DNTs as a novel adjuvant therapy with allo-HSCT to enhance the treatment efficacy in r/r AML. The finding of TIGIT, PD-1, CD57 molecules were increased on patients' T cells indicated that the combination of DNTs with immune checkpoint inhibitors may further improve the DNTs efficacy in r/r AML patients.
Clinical
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CD8 (cluster of differentiation 8) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • CD4 (CD4 Molecule) • B3GAT1 (Beta-1,3-Glucuronyltransferase 1)
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cyclophosphamide • fludarabine IV • RC1012
over1year
Phase I Clinical Trial of RC1012 Injection in Patients With r/r AML (clinicaltrials.gov)
P1, N=36, Recruiting, Guangdong Ruishun Biotech Co., Ltd | Trial primary completion date: Dec 2022 --> Dec 2023
Trial primary completion date
|
RC1012
over1year
RC1012 Injection (Allo-DNT Cells) for the Prevention of Relapse in AML Patients After Allo-HSCT (clinicaltrials.gov)
P1/2, N=72, Recruiting, Guangdong Ruishun Biotech Co., Ltd | Active, not recruiting --> Recruiting
Enrollment open
|
RC1012
over1year
New P1/2 trial
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RC1012