News - RBPMS expression

3ms

RBPMS-AS1 sponges miR-19a-3p to restrain cervical cancer cells via enhancing PLCL1-mediated pyroptosis. (PubMed, Biotechnol Appl Biochem)

There also existed a targeting relationship and negative interplay between PLCL1 and miR-19a-3p. In short, RBPMS-AS1 sponges miR-19a-3p and represses the growth and EMT of CC cells via enhancing PLCL1-mediated pyroptosis.

3 months ago

Journal

CDH1 (Cadherin 1) • VIM (Vimentin) • CDH2 (Cadherin 2) • RBPMS (RNA-binding protein with multiple splicing) • MIR19A (MicroRNA 19a) • CASP1 (Caspase 1)

CDH1 expression • VIM expression • RBPMS expression

almost2years

Overexpressed RBPMS-AS1 increased cell radiosensitivity by sponging miR-19a-3p in lung cancer cell lines (A549 and SK-MES-1) via regulating PTEN/AKT axis. (PubMed, Int J Radiat Biol)

MiR-19a-3p targeted PTEN and miR-19a-3p mimic reversed the effect of overexpressed RBPMS-AS1 on PTEN and phosphorylation of AKT in LC cells. Overexpressed RBPMS-AS1 sponged miR-19a-3p to increase cell radiosensitivity in LC via regulating PTEN/AKT axis.

almost 2 years ago

Preclinical • Journal

PTEN (Phosphatase and tensin homolog) • MIR19A (MicroRNA 19a)

RBPMS expression

2years

Increased Expression of the RBPMS Splice Variants Inhibits Cell Proliferation in Ovarian Cancer Cells. (PubMed, Int J Mol Sci)

These studies suggest that increased levels of RBPMSA and RBPMSC reduce cell proliferation in ovarian cancer cells. However, only RBPMSA expression levels were associated with the sensitivity of ovarian cancer cells to cisplatin treatment.

2 years ago

Journal

CD31 (Platelet and endothelial cell adhesion molecule 1) • RBPMS (RNA-binding protein with multiple splicing) • PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1)

RBPMS expression

cisplatin

2years

Loss of RBPMS in ovarian cancer compromises the efficacy of EGFR inhibitor gefitinib through activating HER2/AKT/mTOR/P70S6K signaling. (PubMed, Biochem Biophys Res Commun)

The combination of AKT inhibitor MK2206 and gefitinib had a synergistic effect on OC cells with high level of RBPMS. In conclusion, through the direct inhibition of HER2/AKT/mTOR/P70S6K pathway, RBPMS may be a potential therapeutic target for improving gefitinib sensitivity in OC.

2 years ago

Journal

HER-2 (Human epidermal growth factor receptor 2)

HER-2 expression • RBPMS expression

gefitinib • MK-2206

over2years

Role of RNA Binding Protein with Multiple Splicing (RBPMS) Variants in Cell Proliferation, Invasion and Angiogenesis in Ovarian Cancer. (PubMed, FASEB J)

However, only the isoform A contributed to the cisplatin sensitivity of ovarian cancer cells. Future efforts on this project will be focused on determining the RBPMS isoform that represses AP-1 (c-Fos and c-Jun) dependent gene regulation in cisplatin sensitive ovarian cancer cells.

over 2 years ago

Journal

CD31 (Platelet and endothelial cell adhesion molecule 1) • RBPMS (RNA-binding protein with multiple splicing) • FOS (Fos Proto-Oncogene AP-1 Transcription Factor Subunit 2) • JUN (Jun proto-oncogene) • SMAD3 (SMAD Family Member 3)

RBPMS expression

cisplatin

almost3years

RBPMS2, as a novel biomarker for predicting lymph node metastasis, guides therapeutic regimens in gastric cancer. (PubMed, Hum Cell)

We also focus on the correlation analysis between EMT-related genes and RBPMS2/ESRP1. Finally, we analysed the correlation between RBPMS2 expression and chemotherapeutic drugs which may assist in GC therapy and demonstrated that RBPMS2 expression was associated with tumour mutation burden (TMB) and Microsatellite Instability (MSI), as well as immune infiltration level in GC.

almost 3 years ago

Journal • Tumor Mutational Burden

TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • ESRP1 (Epithelial Splicing Regulatory Protein 1) • RBPMS (RNA-binding protein with multiple splicing)

RBPMS expression