^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    RBMX (RNA Binding Motif Protein X-Linked)

    i
    Other names: RBMX, RNA Binding Motif Protein X-Linked, Heterogeneous Nuclear Ribonucleoprotein G, HnRNP-G, HNRNPG, RNMX, RNA-Binding Motif Protein, X Chromosome, Glycoprotein P43, HnRNP G, RBMXP1, HNRPG, RNA Binding Motif Protein, X Chromosome, MRXS11, RBMXRT
    Associations

    News

    Trials
    3ms
    RBMX2 links Mycobacterium bovis infection to epithelial-mesenchymal transition and lung cancer progression. (PubMed, Elife)
    Collectively, RBMX2 is a novel host factor that enhances M. bovis infection and drives infection-induced EMT. These findings provide new insight into TB pathogenesis and highlight RBMX2 as a potential target for TB vaccine and therapeutic development.
    Journal
    |
    MMP9 (Matrix metallopeptidase 9) • MX2 (MX Dynamin Like GTPase 2) • RBMX (RNA Binding Motif Protein X-Linked)
    5ms
    The RNA-Binding Protein RBMX Mediates the Immunosuppressive Microenvironment of Osteosarcoma by Regulating CD8+T Cells. (PubMed, Cancers (Basel))
    Finally, cell communication and in vitro experimental verification revealed that knocking out RBMX might enhance the infiltration of CD8+T cells by upregulating histocompatibility 2, K1, and K region (H2-K1) and downregulating thrombospondin 1 (THBS1). This study may provide potential targets for reshaping the immune microenvironment of osteosarcoma and improving its therapeutic efficacy.
    Journal
    |
    CD8 (cluster of differentiation 8) • RBMX (RNA Binding Motif Protein X-Linked)
    8ms
    Alternative splicing in the RBMXL1 5'-UTR induces uORF-mediated translation control in activated B lymphocytes. (PubMed, Sci Rep)
    Our findings indicate that the RBMXL1 uORF is functional and that its presence results in the downregulation of the translation of the downstream primary ORF. Regulation of this alternative splicing may therefore play an important role in the fine-tuning of the global level of RBMX/RBMXL1 proteins in the cells.
    Journal • IO biomarker
    |
    CD40LG (CD40 ligand) • IL4 (Interleukin 4) • RBMX (RNA Binding Motif Protein X-Linked)
    1year
    m6A-related genes ALKBH5 and RBMX as prognostic and progression biomarkers in Chinese oral squamous cell carcinoma patients. (PubMed, Arch Oral Biol)
    We found the upregulation of m6A status in OSCC, of which, ALKBH5 and RBMX may serve as promising diagnostic and prognostic biomarkers for Chinese patients with OSCC.
    Journal
    |
    ALKBH5 (AlkB Homolog 5, RNA Demethylase) • HNRNPA2B1 (Heterogeneous Nuclear Ribonucleoprotein A2/B1) • HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C) • IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) • METTL14 (Methyltransferase 14) • RBMX (RNA Binding Motif Protein X-Linked) • YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein 2) • LRPPRC (Leucine Rich Pentatricopeptide Repeat Containing)
    almost2years
    Spliceosomic dysregulation in pancreatic cancer uncovers splicing factors PRPF8 and RBMX as novel candidate actionable targets. (PubMed, Mol Oncol)
    Experimental modulation of these splicing factors in pancreatic cancer cell lines reverted their expression to non-tumor levels and resulted in decreased key tumor-related features. These results provide evidence that the splicing machinery is altered in PDAC, wherein PRPF8 and RBMX emerge as candidate actionable therapeutic targets.
    Journal
    |
    RBMX (RNA Binding Motif Protein X-Linked) • PRPF8 (Pre-MRNA Processing Factor 8)
    2years
    RBMX overexpression inhibits proliferation, migration, invasion and glycolysis of human bladder cancer cells by downregulating PKM2 (PubMed, Nan Fang Yi Ke Da Xue Xue Bao)
    RBMX overexpression inhibits bladder cancer progression and lowers glycolysis level in bladder cancer cells by downregulating PKM2 expression, suggesting the potential of RBMX as a molecular target for diagnosis and treatment of bladder cancer.
    Journal
    |
    PKM (Pyruvate Kinase M1/2) • RBMX (RNA Binding Motif Protein X-Linked)
    2years
    Aberrant RBMX expression is relevant for cancer prognosis and immunotherapy response. (PubMed, Aging (Albany NY))
    The results showed that knockdown of RBMX can impair the proliferation, migration, and invasion of liver cancer cells. Finally, we indicated that RBMX may play an immunoregulatory role in cancer progression, affecting the therapeutic effects of immune checkpoint inhibitors in patients with cancer.
    Journal • IO biomarker
    |
    RBMX (RNA Binding Motif Protein X-Linked)
    over2years
    m6A reading protein RBMX as a biomarker for prognosis and tumor progression in esophageal cancer. (PubMed, Transl Cancer Res)
    RBMX may be as a biomarker of poor prognosis of ESCA. RBMX is closely related to the survival and prognosis, genetic mutation and immune cell infiltration of patients with ESCA.
    Journal
    |
    RBMX (RNA Binding Motif Protein X-Linked)
    over2years
    Splicing factor TRA2A contributes to esophageal cancer progression via a noncanonical role in lncRNA m A methylation. (PubMed, Cancer Sci)
    Cellular thermal shift and RIP assay indicated that nebivolol may compete with MALAT1 to bind TRA2A. In conclusion, our study revealed the noncanonical function of TRA2A, which coordinates with multiple methylation proteins to promote oncogenic MALAT1 during ESCA carcinogenesis.
    Journal
    |
    MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • METTL3 (Methyltransferase Like 3) • RBMX (RNA Binding Motif Protein X-Linked)
    almost3years
    Comprehensive analysis of m6A related gene mutation characteristics and prognosis in colorectal cancer. (PubMed, BMC Med Genomics)
    Our study identified novel prognostic markers associated with immune of CRC cancer patients. Moreover, the potential mechanisms of prognostic markers in regulating the etiology of CRC cancer were investigated. These findings enrich our understanding of the relationships between m6a related genes and CRC, and may provide novel ideas in the therapy of CRC patients.
    Journal
    |
    IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • YTHDC1 (YTH Domain Containing 1) • ALKBH5 (AlkB Homolog 5, RNA Demethylase) • FMR1 (Fragile X Messenger Ribonucleoprotein 1) • HNRNPC (Heterogeneous Nuclear Ribonucleoprotein C) • IGF2BP2 (Insulin Like Growth Factor 2 MRNA Binding Protein 2) • IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) • METTL14 (Methyltransferase 14) • METTL3 (Methyltransferase Like 3) • RBMX (RNA Binding Motif Protein X-Linked) • WTAP (WT1 Associated Protein) • YTHDC2 (YTH N6-Methyladenosine RNA Binding Protein C2) • YTHDF1 (YTH N6-Methyladenosine RNA Binding Protein 1) • YTHDF2 (YTH N6-Methyladenosine RNA Binding Protein 2)