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    GENE:

    RBM33 (RNA Binding Motif Protein 33)

    i
    Other names: RBM33, RNA Binding Motif Protein 33, PRR8, RNA-Binding Protein 33, Proline-Rich Protein 8, Proline Rich 8, DKFZp434D1319, DKFZp686F102, MGC20460, Hypothetical Protein MGC20460, RNA-Binding Motif Protein 33
    Associations

    News

    Trials
    4ms
    CircRBM33 facilitates colorectal cancer progression by regulating the miR-512-5p/SLC1A5 axis. (PubMed, Pathol Res Pract)
    CircRBM33 boosted CRC development partly by regulating the miR-512-5p/SLC1A5 axis, providing a promising therapeutic target for CRC therapy.
    Journal
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    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CCND1 (Cyclin D1) • SLC1A5 (Solute Carrier Family 1 Member 5) • RBM33 (RNA Binding Motif Protein 33)
    1year
    CircRBM33 competitively binds miR-15a-5p to mediate EZH1 expression to ameliorate sepsis-induced acute lung injury. (PubMed, Clinics (Sao Paulo))
    CircRBM33 improves ALI in septic mice by targeting the miR-15a-5p/EZH1 axis.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • EZH2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) • MIR15A (MicroRNA 15a) • RBM33 (RNA Binding Motif Protein 33)
    over2years
    RBM33 is a unique mA RNA-binding protein that regulates ALKBH5 demethylase activity and substrate selectivity. (PubMed, Mol Cell)
    RBM33 promotes autophagy by recruiting ALKBH5 to demethylate and stabilize DDIT4 mRNA, which is responsible for the oncogenic function of RBM33 in HNSCC cells. Altogether, our study uncovers the mechanism of selectively demethylate mA methylation of a subset of transcripts during tumorigenesis that may explain demethylation selectivity in other cellular processes, and we showed its importance in the maintenance of tumorigenesis of HNSCC.
    Journal
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    ALKBH5 (AlkB Homolog 5, RNA Demethylase) • DDIT4 (DNA Damage Inducible Transcript 4) • RBM33 (RNA Binding Motif Protein 33)