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    GENE:

    RBM24 (RNA Binding Motif Protein 24)

    i
    Other names: RBM24, RNA Binding Motif Protein 24, DJ259A10.1, RNPC6, RNA-Binding Region (RNP1, RRM) Containing 6, RNA-Binding Region-Containing Protein 6, RNA-Binding Protein 24, FLJ30829, RNA-Binding Motif Protein 24
    Associations

    News

    Trials
    12d
    Cuproptosis-induced upregulation of RBM24 suppresses tumor metastasis via MAPK signaling blockage in colorectal cancer. (PubMed, Arch Med Sci)
    Elevated levels of cuproptosis-induced cell death disrupt the MAPK signaling cascade, thus suppressing the metastasis of CRC. This discovery sheds new light on the potential application of cuproptosis in oncological treatments.
    Journal
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    RBM24 (RNA Binding Motif Protein 24)
    3ms
    Single-Cell Heterogeneity of Epigenetic Factor Regulation Deciphers Alteration of RNA Metabolism During Proliferative SHH-Medulloblastoma. (PubMed, Cancers (Basel))
    Expression heterogeneity of epigenetic regulators is closely associated with molecular subgroups and clinical outcomes in medulloblastoma. These findings highlight the role of epigenetic dysregulation in RNA metabolism and tumor progression, particularly in SHH-driven proliferative cells.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • FOXA1 (Forkhead Box A1) • SMARCD3 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily D, Member 3) • RBM24 (RNA Binding Motif Protein 24)
    8ms
    Expression of Concern. (PubMed, Eur Rev Med Pharmacol Sci)
    Downregulated long non-coding RNA TRPM2-AS inhibits cisplatin resistance of non-small cell lung cancer cells via activation of p53- p66shc pathway...PMID: 33577026. The Publisher apologizes for any inconvenience this may cause.
    Journal
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    IGF2 (Insulin-like growth factor 2) • MIR200B (MicroRNA 200b) • NEAT1 (Nuclear Paraspeckle Assembly Transcript 1) • FUS (FUS RNA Binding Protein) • TIMP2 (TIMP Metallopeptidase Inhibitor 2) • AFAP1-AS1 (AFAP1 Antisense RNA 1) • FOXO3 (Forkhead box O3) • PCNA (Proliferating cell nuclear antigen) • GAS5 (Growth Arrest Specific 5) • SMAD7 (SMAD Family Member 7) • DSCAM (DS Cell Adhesion Molecule) • HOXA-AS2 (HOXA Cluster Antisense RNA 2) • MIR29A (MicroRNA 29a) • MIR483 (MicroRNA 483) • MMP7 (Matrix metallopeptidase 7) • RBM24 (RNA Binding Motif Protein 24) • SNHG7 (Small Nucleolar RNA Host Gene 7) • TGFBR1 (Transforming Growth Factor Beta Receptor 1) • TGIF2 (TGFB Induced Factor Homeobox 2) • WTAP (WT1 Associated Protein) • XIST (X Inactive Specific Transcript) • MAGI2-AS3 (MAGI2 Antisense RNA 3)
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    cisplatin
    11ms
    RBM24 regulates apoptosis rates by modulating global transcriptome profile in CAL27 cells. (PubMed, Sci Rep)
    More notably, we found that RBM24 binds to lncRNAs in addition to pre-mRNAs. These results indicated that RBM24 could play a key role in cancer progression by finding clinical therapeutic targets for Oral squamous cell carcinoma.
    Journal
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    RBM24 (RNA Binding Motif Protein 24)
    over1year
    DNA methylation as a new tool for the differential diagnosis between T-LBL and lymphocyte-rich thymoma. (PubMed, J Pathol)
    © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland
    Journal • Epigenetic controller
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    CDC42BPB (CDC42 Binding Protein Kinase Beta) • RBM24 (RNA Binding Motif Protein 24) • CASC2 (Cancer Susceptibility 2)
    over1year
    Comprehensive analysis of the functions, prognostic and diagnostic values of RNA binding proteins in head and neck squamous cell carcinoma. (PubMed, J Stomatol Oral Maxillofac Surg)
    Our results demonstrate the value of consideration of RBP in the diagnosis and prognosis for HNSCC and provide a novel insight into understanding the potential role of dysregulated RBP in HNSCC.
    Journal • PARP Biomarker
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    DNMT3B (DNA Methyltransferase 3 Beta) • IGF2BP1 (Insulin Like Growth Factor 2 MRNA Binding Protein 1) • AFF3 (AF4/FMR2 Family Member 3) • EIF5A2 (Eukaryotic Translation Initiation Factor 5A2) • RBM24 (RNA Binding Motif Protein 24)
    almost2years
    RBM24 Suppresses the Tumorigenesis of Glioblastoma by Stabilizing LATS1 mRNA. (PubMed, Biochem Genet)
    There was also correlation between RBM24 and LATS1 protein expression in the xenograft tumors. RBM24 functions to stabilize LATS1 mRNA, thereby inhibiting the proliferation, suppressing invasion, and promoting apoptosis in GBM cells.
    Journal
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    LATS1 (Large Tumor Suppressor Kinase 1) • RBM24 (RNA Binding Motif Protein 24)
    almost2years
    EXPRESS: YAP1-induced RBM24 promotes the tumorigenesis of triple-negative breast cancer through the β-catenin pathway. (PubMed, J Investig Med)
    Collectively, the YAP1/RBM24/β-catenin axis plays a critical role in driving TNBC progression. RBM24 may represent a novel therapeutic target for TNBC treatment.
    Journal
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    ARID1A (AT-rich interaction domain 1A) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • YAP1 (Yes associated protein 1) • RBM24 (RNA Binding Motif Protein 24)
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    YAP1 overexpression
    2years
    Tropomyosin1 isoforms underlie epithelial to mesenchymal plasticity, metastatic dissemination, and resistance to chemotherapy in high-grade serous ovarian cancer. (PubMed, Cell Death Differ)
    Moreover, Tpm1.8/9 expression confers resistance to taxane- and platinum-based chemotherapy. Small molecule inhibitors that target the Tpm1 isoforms support targeting Tpm1.8/9 as therapeutic targets for the development of future tailor-made clinical interventions.
    Journal • Metastases
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    ESRP1 (Epithelial Splicing Regulatory Protein 1) • RBM24 (RNA Binding Motif Protein 24)
    over3years
    Mechanism of METTL14-mediated mA modification in non-small cell lung cancer cell resistance to cisplatin. (PubMed, J Mol Med (Berl))
    • miR-19a-5p targets RBM24, thus reducing the binding of RBM24 and AXIN1 and inhibiting AXIN1 transcription. • METTL14 silencing in vivo enhances the suppressive role of DDP to tumor growth.
    Journal
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    AXIN1 (Axin 1) • METTL14 (Methyltransferase 14) • MIR19A (MicroRNA 19a) • RBM24 (RNA Binding Motif Protein 24)
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    KIT expression
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    cisplatin
    over3years
    RNA Binding Proteins (RBPs) and their role in DNA Damage and radiation response in cancer. (PubMed, Adv Drug Deliv Rev)
    the role of RBPs, including HuR, in breast cancer progression and DNA damage response and iii). explore RBPs with emphasis on HuR as therapeutic target for breast cancer therapy.
    Review • Journal
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    HNRNPD (Heterogeneous Nuclear Ribonucleoprotein D) • RBM38 (RNA Binding Motif Protein 38) • RBM24 (RNA Binding Motif Protein 24)
    over3years
    Rare ocular toxicity induced by pertuzumab/QL1209 in healthy chinese subjects: case reports and whole-exome sequencing analysis. (PubMed, Invest New Drugs)
    In summary, this is the first report describing the occurrence of ocular toxicity induced by pertuzumab in the Chinese population and exploring the possible genetic mechanisms. These findings could provide evidence for clinicians to raise concerns about the risk of ocular toxicity with the clinical use of pertuzumab.
    Journal
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    mTOR (Mechanistic target of rapamycin kinase) • IRS2 (Insulin receptor substrate 2) • CDH23 (Cadherin Related 23) • RBM24 (RNA Binding Motif Protein 24)
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    HER-2 positive
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    Perjeta (pertuzumab) • Ansaizhu (pertuzumab biosimilar)