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    over1year
    Nanoscale, antigen encounter-dependent, IL-12 delivery by CAR T cells plus PD-L1 blockade for cancer treatment. (PubMed, J Transl Med)
    RB-312, the first clinically relevant product incorporating a CRISPRa system with non-gene editing and reversible upregulation of endogenous gene expression that promotes CAR-T cells persistence and effectiveness against HER2-expressing tumors. The autocrine effects of reversible, nanoscale IL-12 production limits the risk of off-tumor leakage and systemic toxicity.
    Journal • CAR T-Cell Therapy • PD(L)-1 Biomarker • IO biomarker
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    RELA (RELA Proto-Oncogene)
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    HER-2 expression
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    RB-312