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    BIOMARKER:

    RASGRP1 overexpression

    i
    Other names: RASGRP1, RAS Guanyl Releasing Protein 1, RASGRP, Calcium- And Diacylglycerol-Regulated Guanine Nucleotide Exchange Factor II, Calcium And DAG-Regulated Guanine Nucleotide Exchange Factor II, RAS Guanyl Releasing Protein 1 (Calcium And DAG-Regulated), RAS Guanyl-Releasing Protein 1, CalDAG-GEFII, Guanine Nucleotide Exchange Factor, Calcium- And DAG-Regulated, Rap1A, RAS Guanyl Nucleotide-Releasing Protein 1, Ras Guanyl-Releasing Protein, Ras Activator RasGRP, CALDAG-GEFII, CALDAG-GEFI, RASGRP1, I
    Entrez ID:
    10125
    almost2years
    RasGRP1 promotes the acute inflammatory response and restricts inflammation-associated cancer cell growth. (PubMed, Nat Commun)
    Tumour patients with high RasGRP1 expression have better clinical outcomes than those with low RasGRP1 expression. Considering that acute inflammation rarely leads to tumorigenesis, this study suggests that RasGRP1 may be an important bifunctional regulator of the acute inflammatory response and tumour growth.
    Journal
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    IL6 (Interleukin 6) • RASGRP1 (RAS Guanyl Releasing Protein 1)
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    IL6 expression • RASGRP1 overexpression
    almost4years
    Investigating increased hematopoietic stem cell fitness in a novel mouse model. (PubMed, Small GTPases)
    Intriguingly, this increased fitness only manifests in native hematopoiesis, and not in BM transplantation (BMT) assays. In this commentary we summarize key features of our RoLoRiG model, elaborate on BM niche importance, and discuss differences between native hematopoiesis and BMT in the context of stem cell metabolism.
    Preclinical • Journal
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    RASGRP1 (RAS Guanyl Releasing Protein 1)
    |
    RASGRP1 overexpression
    almost4years
    Increased baseline RASGRP1 signals enhance stem cell fitness during native hematopoiesis. (PubMed, Oncogene)
    In agreement with these mechanistic findings, hRASGRP1-ires-EGFP enhances fitness of stem- and progenitor- cells, but only in the context of native hematopoiesis. RASGRP1 overexpression is distinct from KRAS or NRAS, does not cause acute leukemia on its own, and leukemia virus insertion frequencies predict that RASGRP1 overexpression can effectively cooperate with lesions in many other genes to cause acute T-ALL.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • NRAS (Neuroblastoma RAS viral oncogene homolog) • RASGRP1 (RAS Guanyl Releasing Protein 1)
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    KRAS mutation • NRAS mutation • RASGRP1 overexpression