RARRES2 (Retinoic Acid Receptor Responder 2)

By systematically integrating 101 machine learning models derived from 10 algorithms, we constructed a Wnt-CAF-driven risk signature. Combined with clinicopathological features in a nomogram, this model effectively predicted prognosis and potential immunotherapy response in dMMR EC. These findings deepen the understanding of the EC microenvironment and provide valuable guidance for personalized treatment strategies and prognostic assessment in clinical practice.

In IBD, chemerin exacerbates colitis via impaired macrophage polarization, yet protects epithelial antimicrobial defense, underscoring its context-specific biology. Collectively, these findings position chemerin as a versatile regulator bridging metabolic dysfunction, inflammation, and gastrointestinal malignancy, and as a potential candidate for biomarker development and therapeutic intervention.

Chemerin binds to its receptors to influence tumor growth and metastasis by regulating the inflammatory response and tumor microenvironment. In this paper, the mechanism of chemerin and its receptors in the tumor microenvironment was summarized, providing theoretical basis for further study of the mechanism of chemerin in tumors and for molecular targeted therapy based on chemerin.

Using NicheNet, a publicly available database of hepatic mRNA expression in DIAMOND mice, and a PTH-induced model of bone loss, we suggest Ctgf, Rarres2, Anxa2, Fgf21, and Mmp13 are liver-secreted ligands inducing bone resorption. This study is the first preclinical investigation of bone loss in MASLD, and the first to suggest the role of Ctgf, Rarres2, Anxa2, Fgf21, and Mmp13 as drivers of this pathology.

Several Protein EpiScores, including many related to immune response, were associated with breast cancer risk, highlighting novel changes to the peripheral immune system that occur during breast cancer development.

This MR analysis revealed numerous plasma proteins associated with inflammatory skin diseases, offering insights into protein-mediated mechanisms and highlighting promising therapeutic targets for future interventions. Key message What is already known on this topic  Inflammatory skin diseases, including psoriasis, atopic dermatitis, and acne, are complex conditions linked to systemic factors such as alterations in circulating plasma proteins. Previous studies have identified certain proteins involved in skin immune responses; however, a comprehensive understanding of their causal roles remains lacking. What this study adds  This study utilized a large-scale proteome-wide Mendelian randomization analysis to identify >100 circulating proteins causally linked to inflammatory skin diseases. Notably, proteins such as RARRES2, SERPINC1, and ECM1 were highlighted as potential therapeutic targets for atopic dermatitis and acne, among others. How this study might affect research, practice, or policy  The findings provide novel insights into protein-mediated mechanisms underlying inflammatory skin diseases, suggesting new diagnostic and therapeutic avenues. Future research should focus on validating these protein targets in clinical settings and exploring their potential for therapeutic intervention.

Our findings suggest that circulating metabolites may non-invasively detect clinical and molecular differences in patients with LVD, providing insights into underlying disease pathways and potential therapeutic targets.

Using NicheNet, a publicly available database of hepatic mRNA expression in DIAMOND mice, and a PTH-induced model of bone loss, we suggest Ctgf, Rarres2, Anxa2, Fgf21, and Mmp13 are liver-secreted ligands inducing bone resorption. This study is the first preclinical investigation of bone loss in MASLD, and the first to suggest the role of Ctgf, Rarrest2, Anxa2, Fgf21, and Mmp13 as drivers of this pathology.

Other studies revealed that lipid metabolic reprogramming is part of metabolic adaptation to central nervous system. Overall, there is an intricate connection between lipid metabolism and brain metastases, and disrupting this connection may be a potential therapeutic target for BCBrM treatment.

P=N/A, N=60, Completed, Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Taking together, we identified a four-gene prognostic CAFs signature, which was proven to be a reliable indicator for prognosis and therapeutic efficacy in patients with BRCA. This study provided evidence for novel CAFs-based stromal therapy.

OSCs are highly heterogeneous, and different subgroups are responsible for proliferation and communication with other cells. The IGF-RARRES2 axis plays a key role in maintaining OSC stemness through communication with TAMs.