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    GENE:

    RAET1G (Retinoic Acid Early Transcript 1G)

    i
    Other names: RAET1G, Retinoic Acid Early Transcript 1G, ULBP5, Retinoic Acid Early Transcript 1G Protein, UL-16 Binding Protein 5, Retinoic Acid Early Transcript 1G Pseudogene
    Associations

    News

    Trials
    over2years
    KDM6A Modulates Anti-Tumor Immune Response By Integrating Immunogenic Cell Death in Human Acute Myeloid Leukemia (ASH 2023)
    We have identified that in comparison to control AML cells, deficiency of KDM6A (KDM6A-kd) associated with daunorubicin/etoposide-induced ICD, which was manifested by significant increase (2-3 fold, P<0.05) in ecto-CRT, plasma membrane exposure of pE1F2α, HSP70 and HSP90 with extracellular release of HMGB1 and ATP. In addition, olaparib and GSK-J4 treatment showed additive effects in ICD and immune activation using primary AML CD34+ cells. Together, we illustrate that KDM6A regulates ICD through epigenetic mechanisms, while KDM6A deficient AML subtypes could be sensitized with immunomodulatory targeted therapy.
    Tumor mutational burden • BRCA Biomarker • PARP Biomarker • IO biomarker
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    TMB (Tumor Mutational Burden) • KDM6A (Lysine Demethylase 6A) • CD34 (CD34 molecule) • HMGB1 (High Mobility Group Box 1) • CALR (Calreticulin) • HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5) • STAT1 (Signal Transducer And Activator Of Transcription 1) • ATF4 (Activating Transcription Factor 4) • CD80 (CD80 Molecule) • CD86 (CD86 Molecule) • HSP90AA1 (Heat Shock Protein 90 Alpha Family Class A Member 1Heat Shock Protein 90 Alpha Family Class A Member 1) • IFNB1 (Interferon Beta 1) • NKG2D (killer cell lectin like receptor K1) • RAET1G (Retinoic Acid Early Transcript 1G) • ULBP1 (UL16 Binding Protein 1)
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    TMB-L • KDM6A expression
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    Lynparza (olaparib) • etoposide IV • daunorubicin • GSKJ4
    over3years
    A signature based on NKG2D ligands to predict the recurrence of hepatocellular carcinoma after radical resection. (PubMed, Cancer Med)
    The signature based on MICA, ULBP3, and ULBP5 could predict HCC recurrence.
    Journal
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    NKG2D (killer cell lectin like receptor K1) • RAET1G (Retinoic Acid Early Transcript 1G)