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    GENE:

    RAD54L2 (RAD54 Like 2)

    i
    Other names: RAD54L2, RAD54 Like 2, ARIP4, KIAA0809, SRISNF2L, Androgen Receptor-Interacting Protein 4, AR Interacting Protein 4, RAD54-Like Protein 2, Helicase ARIP4, RAD54 Like 2 (S. Cerevisiae), HSPC325
    Associations

    News

    Trials
    1m
    NePtune: Study of Neoadjuvant PARP Inhibition Followed by Radical Prostatectomy in Patients With Unfavorable Intermediate-Risk or High-Risk Prostate Cancer With Select HRR Gene Alterations (clinicaltrials.gov)
    P2, N=32, Recruiting, Rana McKay, MD | Trial primary completion date: Dec 2025 --> Mar 2026
    Trial primary completion date
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • CDK12 (Cyclin dependent kinase 12) • CHEK2 (Checkpoint kinase 2) • FANCA (FA Complementation Group A) • RAD51B (RAD51 Paralog B) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • RAD51C (RAD51 paralog C) • RAD51D (RAD51 paralog D) • BARD1 (BRCA1 Associated RING Domain 1) • RAD54L2 (RAD54 Like 2)
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    Lynparza (olaparib) • triptorelin • goserelin acetate • leuprolide acetate for depot suspension
    1year
    The BLM-TOP3A-RMI1-RMI2 proximity map reveals that RAD54L2 suppresses sister chromatid exchanges. (PubMed, EMBO Rep)
    RAD54L2 is important for recruitment of BLM to chromatin and requires an intact ATPase domain to promote non-crossover recombination. Thus, the BTRR proximity map identifies a regulator of recombination.
    Journal
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    HRD (Homologous Recombination Deficiency) • BLM (BLM RecQ Like Helicase) • SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 2) • RAD54L2 (RAD54 Like 2)
    over1year
    DNA-Damaging Therapies in Patients With Prostate Cancer and Pathogenic Alterations in Homologous Recombination Repair Genes. (PubMed, JCO Precis Oncol)
    Patients with BRCA1/2-mutated PC had significantly improved outcomes to PARPi but not platinum chemotherapy compared with those with HRR mutations without direct BRCA complex interaction.
    Retrospective data • Journal • BRCA Biomarker • PARP Biomarker
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    HRD (Homologous Recombination Deficiency) • PALB2 (Partner and localizer of BRCA2) • CDK12 (Cyclin dependent kinase 12) • BRCA (Breast cancer early onset) • CHEK2 (Checkpoint kinase 2) • FANCA (FA Complementation Group A) • RAD51B (RAD51 Paralog B) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • CHEK1 (Checkpoint kinase 1) • BARD1 (BRCA1 Associated RING Domain 1) • FANCL (FA Complementation Group L) • GEN1 (GEN1 Holliday junction 5' flap endonuclease) • RAD54L2 (RAD54 Like 2)
    2years
    RAD54L2 counters TOP2-DNA adducts to promote genome stability. (PubMed, Sci Adv)
    Anticancer agents such as etoposide operate by stabilizing TOP2ccs, ultimately generating genotoxic TOP2-DNA protein cross-links that require processing and repair...Our work suggests a model wherein RAD54L2 recognizes sumoylated TOP2 and, using its ATPase activity, promotes TOP2cc resolution and prevents DSB exposure. These findings suggest RAD54L2-mediated TOP2cc resolution as a potential mechanism for cancer therapy resistance and highlight RAD54L2 as an attractive candidate for drug discovery.
    Journal
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    TOP2A (DNA topoisomerase 2-alpha) • RAD54L2 (RAD54 Like 2) • ZNF451 (Zinc Finger Protein 451)
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    etoposide IV
    almost3years
    Estrogen associates with female predominance in Xp11.2 translocation renal cell carcinoma. (PubMed, Sci Rep)
    Downregulation of Rad54l2 was in numerous cancers, including renal cell carcinoma (RCC), in which Rad54l2 expression was significantly decreased in male, age over 60 years old, T2&T3&T4 stages, pathologic SII&SIII&SIV stages as well as histologic G3&G4 grades, and cox regression analysis proved that Rad54l2 expression was a risk factor for overall survival, disease-specific survival and progression-free interval in univariate analysis. There existed female predominance in Xp11.2 tRCC and Rad54l2 might play vital role in estrogen mediating female predominance in Xp11.2 tRCC.
    Retrospective data • Journal
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    RAD54L2 (RAD54 Like 2)
    over3years
    Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population. (PubMed, BMC Cancer)
    Our study first revealed that RAD54L2 rs9864693 was associated with an increased risk of lung cancer in the Chinese Han population. This study may increase the understanding of the effect of RAD54L2 and GTF2H1 polymorphisms on lung cancer occurrence.
    Journal
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    ERCC3 (ERCC Excision Repair 3, TFIIH Core Complex Helicase Subunit) • RAD54L2 (RAD54 Like 2)
    over3years
    CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis. (PubMed, Life Sci)
    Our results showed that circRAD54L2 could regulate PDK1 expression by sponging the miR-888 family competing for the ceRNA mechanism, indicating that circRAD54L2 may act as an essential upstream regulator and providing further mechanistic evidence to support the notion that circRAD54L2/miR-888s/PDK1 is a promising therapeutic target in the treatment of breast cancer.
    Journal
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    MIR888 (MicroRNA 888) • PDK1 (Pyruvate Dehydrogenase Kinase 1) • RAD54L2 (RAD54 Like 2)