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GENE:

RAD54B (RAD54 Homolog B)

News alerts, weekly reports and conference planners

27d

Integrated mutational landscape analysis of endometrial stromal sarcoma. (PubMed, Proc Natl Acad Sci U S A)

Finally, in an activating NRAS-mutant (p.Q61R) HG-ESS xenograft, the combination of MEK and FAK inhibition dramatically suppressed tumor growth and prolonged survival, highlighting a promising targeted treatment strategy. Overall, our comprehensive analysis defines the molecular basis of ESS and provides a strong preclinical rationale for precision therapies in this aggressive cancer.

27 days ago

Journal • Tumor mutational burden • IO biomarker

TP53 (Tumor protein P53) • TMB (Tumor Mutational Burden) • NRAS (Neuroblastoma RAS viral oncogene homolog) • PTEN (Phosphatase and tensin homolog) • STK11 (Serine/threonine kinase 11) • CDKN2A (Cyclin Dependent Kinase Inhibitor 2A) • RB1 (RB Transcriptional Corepressor 1) • TSC2 (TSC complex subunit 2) • JAZF1 (JAZF Zinc Finger 1) • RAD54B (RAD54 Homolog B) • SUZ12 (SUZ12 Polycomb Repressive Complex 2 Subunit)

TP53 mutation • NRAS mutation • STK11 mutation • NRAS Q61

Niraparib in Tumors Metastatic to the CNS (clinicaltrials.gov)

P2, N=20, Active, not recruiting, Massachusetts General Hospital | Trial primary completion date: Dec 2025 --> Dec 2026

1 month ago

Trial primary completion date

BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • HRD (Homologous Recombination Deficiency) • BAP1 (BRCA1 Associated Protein 1) • RAD51B (RAD51 Paralog B) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • RAD51C (RAD51 paralog C) • RAD50 (RAD50 Double Strand Break Repair Protein) • PARP1 (Poly(ADP-Ribose) Polymerase 1) • BARD1 (BRCA1 Associated RING Domain 1) • NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)) • RAD54L (DNA Repair And Recombination Protein RAD54) • XRCC2 (X-Ray Repair Cross Complementing 2) • RAD54B (RAD54 Homolog B) • XRCC3 (X-Ray Repair Cross Complementing 3)

HRD • ATM mutation • PALB2 mutation • BRIP1 mutation • RAD51C mutation • RAD51D mutation • RAD51B mutation • BARD1 mutation • RAD54L mutation

Zejula (niraparib)

Integrated transcriptomic and proteomic analysis reveals the mechanistic role of OST in cutaneous squamous cell carcinoma. (PubMed, Neoplasma)

Transcriptomics combined with proteomics analyses revealed that 5 of the top 20 screened pathways were associated with the cell cycle, and ATR, CENPJ, and RAD54B were highlighted as specific targets for OST-mediated regulation. Collectively, these results suggested that OST has a potential inhibition on human CSCC cells, and ATR, CENPJ, and RAD54B may be the key factors regulated by OST in A431's cell cycle progression inhibition.

1 month ago

Journal

RAD54B (RAD54 Homolog B)

3ms

Prognostic and Immunological Implications of Telomere Maintenance-Related Genes in Breast Cancer: A Mechanistic Exploration. (PubMed, Breast Cancer (Dove Med Press))

Single-cell RNA sequencing highlighted JUN's widespread distribution across multiple cell types, suggesting its crucial role in tumor progression. TM-associated risk model based on WT1, TPRXL, RAD54B, JUN, and SEPHS2 could be used to predict prognosis and treatment of BC.

3 months ago

Journal

WT1 (WT1 Transcription Factor) • RAD54B (RAD54 Homolog B)

3ms

Integrated machine learning and single-cell analysis identify chromatin-remodeling gene signature for diagnosis and prognosis in nasopharyngeal carcinoma. (PubMed, Clin Exp Med)

Notably, experimental validation of PHF14 indicated its involvement in NPC malignancy, with downregulation of PHF14-suppressing cell migration, invasion, and proliferation. These discoveries give fresh perspectives on the molecular processes of NPC and offer potential biomarkers for clinical diagnosis and prognosis.

3 months ago

Journal • Gene Signature

UHRF1 (Ubiquitin Like With PHD And Ring Finger Domains 1) • CDC6 (Cell Division Cycle 6) • RAD54B (RAD54 Homolog B)

6ms

Niraparib in Tumors Metastatic to the CNS (clinicaltrials.gov)

P2, N=20, Active, not recruiting, Massachusetts General Hospital | Recruiting --> Active, not recruiting

6 months ago

Enrollment closed

HRD • ATM mutation • PALB2 mutation • BRIP1 mutation • RAD51C mutation • RAD51D mutation • RAD51B mutation • BARD1 mutation • RAD54L mutation

Zejula (niraparib)

9ms

AP1M2 Drives Gemcitabine-Cisplatin Chemoresistance by Enhancing RAD54B-Associated DNA Repair in Bladder Cancer. (PubMed, FASEB J)

Notably, inhibition of AP1M2/PUM1-mediated RAD54B expression sensitized BC xenografts to gemcitabine-cisplatin treatment in vivo. These findings unveil a novel mechanism of chemotherapy resistance in BC and highlight the AP1M2/PUM1/RAD54B pathway as a promising therapeutic target to counter resistance and enhance treatment outcomes.

9 months ago

Journal

PUM1 (Pumilio RNA Binding Family Member 1) • RAD54B (RAD54 Homolog B)

cisplatin • gemcitabine

9ms

Phase II Study of Niraparib in Patients With Advanced Melanoma With Homologous Recombination Pathway Gene Mutations. (PubMed, JCO Precis Oncol)

Despite the small sample size, our results indicate a promising signal for single agent niraparib in patients with pretreated nonuveal metastatic melanoma with HR gene mutations.

9 months ago

P2 data • Journal • BRCA Biomarker • PARP Biomarker • PD(L)-1 Biomarker • IO biomarker

BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • ARID1A (AT-rich interaction domain 1A) • BAP1 (BRCA1 Associated Protein 1) • PALB2 (Partner and localizer of BRCA2) • ATRX (ATRX Chromatin Remodeler) • CHEK2 (Checkpoint kinase 2) • RAD51 (RAD51 Homolog A) • BRIP1 (BRCA1 Interacting Protein C-terminal Helicase 1) • RAD50 (RAD50 Double Strand Break Repair Protein) • ARID2 (AT-Rich Interaction Domain 2) • BARD1 (BRCA1 Associated RING Domain 1) • MRE11A (MRE11 homolog, double strand break repair nuclease) • FANCD2 (FA Complementation Group D2) • RAD54B (RAD54 Homolog B)

BRAF mutation • ARID1A mutation • PALB2 mutation

Zejula (niraparib)

10ms

Genomic variant profiling in blast-phase paediatric chronic myeloid leukaemia: Predisposing and driving alterations. (PubMed, Br J Haematol)

Our study provides novel pathogenetic insights into paediatric CML-BP. The identification of pathogenic DDR-associated germline variants suggests a genetic predisposition with potential implications for patients and families concerning cancer treatment and surveillance.

10 months ago

Journal

ABL1 (ABL proto-oncogene 1) • ATM (ATM serine/threonine kinase) • RUNX1 (RUNX Family Transcription Factor 1) • ASXL1 (ASXL Transcriptional Regulator 1) • CHEK2 (Checkpoint kinase 2) • SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) • NBN (Nibrin Nijmegen Breakage Syndrome 1 (Nibrin)) • FANCM (FA Complementation Group M) • TP63 (Tumor protein 63) • RECQL4( RecQ Like Helicase 4) • RAD54B (RAD54 Homolog B)

10ms

Metastatic pheochromocytoma complicated with Langerhans cell histiocytosis: a case report. (PubMed, Front Endocrinol (Lausanne))

Genetic analysis was carried out by next-generation sequencing (NGS) technology. Somatic mutations of BRAF and RAD54B were detected in Langerhans cells and EPAS1 in pheochromocytoma.

10 months ago

Journal

BRAF (B-raf proto-oncogene) • EPAS1 (Endothelial PAS domain protein 1) • RAD54B (RAD54 Homolog B)

BRAF mutation

1year

Repeat expansion in a fragile X model is independent of double strand break repair mediated by Pol θ, RAD52, RAD54 or RAD54B. (PubMed, Sci Rep)

These observations put major constraints on what pathways are likely to drive expansion. Together with our previous demonstration of the protective effect of nucleases like EXO1 and FAN1, and the importance of Pol β, they suggest a plausible model for late steps in the expansion process.

1 year ago

Journal

MSI (Microsatellite instability) • RAD54L (DNA Repair And Recombination Protein RAD54) • RAD52 (RAD52 Homolog DNA Repair Protein) • RAD54B (RAD54 Homolog B)

RAD54L mutation