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    GENE:

    RAD51AP1 (RAD51 Associated Protein 1)

    i
    Other names: RAD51AP1, RAD51 Associated Protein 1, PIR51, RAD51-Associated Protein 1, RAD51-Interacting Protein, HsRAD51AP1
    1m
    Biochemical and Comparative Proteomic Analyses Delineate the Anti-Ovarian Carcinogenic Roles of Modified Calycosin. (PubMed, Food Sci Nutr)
    Functional assays confirmed H10's ability to induce cell cycle arrest, senescence, and apoptosis, while proteomic analysis further highlighted its regulatory role in cell cycle regulation and ferroptosis. These findings identify calycosin H10 as a promising therapeutic candidate for ovarian cancer, offering novel insights into its molecular mechanisms of action.
    Journal
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    RAD51 (RAD51 Homolog A) • NCOA4 (Nuclear Receptor Coactivator 4) • GPX4 (Glutathione Peroxidase 4) • RAD51AP1 (RAD51 Associated Protein 1) • ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) • CDK1 (Cyclin-dependent kinase 1) • USP22 (Ubiquitin Specific Peptidase 22) • CCNB1 (Cyclin B1) • USP1 (Ubiquitin Specific Peptidase 1)
    1m
    Phosphoregulation of RAD51AP1 function in homology-directed repair. (PubMed, J Biol Chem)
    We provide evidence that RAD51AP1-S277 is a CDK2 target and propose a model in which RAD51AP1-S277/282 phosphorylation ensures RAD51AP1 flexibility for dynamic engagement in consecutive steps of the HDR reaction. Our results provide new mechanistic insights into RAD51AP1 regulation by a CDK.
    Journal
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    RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1)
    1m
    Differentially Expressed Genes Associated with the Development of Cervical Cancer. (PubMed, Int J Mol Sci)
    The publicly available microarray datasets, including GSE39001, GSE9750, GSE7803, GSE6791, GSE63514, and GSE52903 in combination with bioinformatics database predictions, were used to identify differential expression genes, potential biomarkers, and therapeutic targets for cervical cancer; additionally, we undertook bioinformatic analysis to determine gene ontology and possible miRNA targets related to our DEGs...Interestingly, hub proteins KIF4A, NUSAP1, BUB1B, CEP55, DLGAP5, NCAPG, CDK1, MELK, KIF11, and KIF20A were found to be potentially regulated by several miRNAs, including miR-107, miR-124-3p, miR-147a, miR-16-5p, miR-34a-5p, miR-34c-5p, miR-126-3p, miR-10b-5p, miR-23b-3p, miR-200b-3p, miR-138-5p, miR-203a-3p, miR-214-3p, and let-7b-5p. The relationship between these genes highlights their potential as candidate biomarkers for further research in treatment, diagnosis, and prognosis.
    Journal
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    TP53 (Tumor protein P53) • TOP2A (DNA topoisomerase 2-alpha) • RAD51 (RAD51 Homolog A) • MIR200B (MicroRNA 200b) • MIR34A (MicroRNA 34a-5p) • RAD51AP1 (RAD51 Associated Protein 1) • NUSAP1 (Nucleolar and Spindle Associated Protein 1) • ELF3 (E74 Like ETS Transcription Factor 3) • FOXM1 (Forkhead Box M1) • MELK (Maternal Embryonic Leucine Zipper Kinase) • CDK1 (Cyclin-dependent kinase 1) • KIF11 (Kinesin Family Member 11) • MIR126 (MicroRNA 126) • MIR16 (MicroRNA 16) • MIR23b (MicroRNA 23b) • NCAPG (Non-SMC Condensin I Complex Subunit G) • PLOD2 (procollagen-lysine,2-oxoglutarate 5-dioxygenase 2) • BUB1B (BUB1 Mitotic Checkpoint Serine/Threonine Kinase B) • CEP55 (Centrosomal Protein 55) • CXCL14 (C-X-C Motif Chemokine Ligand 14) • E2F1 (E2F transcription factor 1) • KIF20A (Kinesin Family Member 20A) • KIF4A (Kinesin Family Member 4A) • MCM2 (Minichromosome maintenance complex component 2) • MCM5 (Minichromosome Maintenance Complex Component 5) • MIR10B (MicroRNA 10b) • MIR138 (MicroRNA 138) • MIR203A (MicroRNA 203a) • MIR214 (MicroRNA 214) • MIRLET7B (MicroRNA Let-7b) • RELA (RELA Proto-Oncogene) • RFC4 (Replication Factor C Subunit 4) • MIR124-3 (MicroRNA 124-3)
    3ms
    RAD51AP1 is a versatile RAD51 modulator. (PubMed, Proc Natl Acad Sci U S A)
    Further, we resolved structures of RAD51-ssDNA filaments in the presence of Mg2+-ATP and upon hydrolysis to Mg2+-ADP, revealing that RAD51 filaments expand upon ATP hydrolysis and explaining how ADP reduces RAD51-DNA binding. Our findings reveal RAD51AP1 as a versatile RAD51 modulator and RAD51 filament remodeler and shed previously unidentified insights into the modulation of HR, which is critical for the maintenance of genome stability.
    Journal
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    RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1)
    4ms
    Research Progress of RAD51AP1 in Malignant Tumors of the Female Reproductive System. (PubMed, FASEB J)
    Here, we reviewed the latest research on RAD51AP1 in female reproductive system tumors and summarized its differential expression and prognostic implications. In this review, we also outlined the potential mechanisms of its procancer and drug resistance-promoting effects to provide several potential directions for further research.
    Review • Journal
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    HRD (Homologous Recombination Deficiency) • RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1)
    4ms
    PTTG1IP Orchestrates Epithelial-Mesenchymal Transition and DNA Damage Response in Thyroid Cancer Progression. (PubMed, Front Biosci (Landmark Ed))
    PTTG1IP is a multifunctional node in thyroid cancer, coupling cytoskeletal programs with DDR control, and supporting cell growth and treatment tolerance. The targeting of PTTG1IP, particularly to enhance radiosensitivity, may provide a novel therapeutic strategy for thyroid cancer.
    Journal • BRCA Biomarker
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    BRCA1 (Breast cancer 1, early onset) • BRCA2 (Breast cancer 2, early onset) • RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1) • CTTN (Cortactin)
    5ms
    Phosphoregulation of RAD51AP1 function in homology-directed repair. (PubMed, bioRxiv)
    We provide evidence that RAD51AP1-S277 is a CDK2 target and propose a model in which RAD51AP1-S277/282 phosphorylation ensures RAD51AP1 flexibility for dynamic engagement in consecutive steps of the HDR reaction. Our results provide new mechanistic insights into RAD51AP1 regulation by a CDK.
    Journal
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    RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1)
    7ms
    TSPAN7 inhibits pancreatic cancer progression by suppressing DNA double-strand break repair and enhances sensitivity to immunochemotherapy. (PubMed, Biochem Pharmacol)
    Mechanistically, TSPAN7 inhibited RAD51-associated protein 1-mediated DNA double-strand break repair, activating the cGAS-STING signalling pathway to induce type I interferon production. Overall, TSPAN7 inhibits PDAC cell growth and enhances the anti-tumour immune response, indicating its potential as a promising therapeutic target for PDAC.
    Journal
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    CD8 (cluster of differentiation 8) • RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1)
    8ms
    TERRA R-loops trigger a switch in telomere maintenance towards break-induced replication and PRIMPOL-dependent repair. (PubMed, EMBO J)
    Similarly, we find that PRIMPOL depletion is synthetic-lethal with BIR deficiency in U2OS ALT cancer cells. Therefore, TERRA R-loops by themselves are sufficient to induce ALT-typical telomere repair mechanisms, in the absence of other ALT-typical telomeric chromatin changes.
    Journal
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    RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1)
    9ms
    Transcriptomic analysis of laser-capture microdissected tumors reveals RAD51AP1 as a tumor-specific marker associated progression from pancreatic intraepithelial neoplasia to invasive pancreatic cancer. (PubMed, Cancer Cell Int)
    RAD51AP1 is a tumor-specific molecule that associated with more aggressive behavior, advanced disease, and a worse survival rate.
    Journal
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    RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1)
    11ms
    Epigenetically elevated RAD51AP1 regulates the RAD51-UAF1 complex contributing to temozolomide resistance in EGFRvIII glioblastoma. (PubMed, Chin Med J (Engl))
    The results of this study suggest that aberrant RAD51AP1 expression is a crucial mechanism by which EGFRvIII-mutant glioblastoma resists TMZ chemotherapy, laying the groundwork for future personalized medicine.
    Journal
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    EGFR (Epidermal growth factor receptor) • RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1) • SOX9 (SRY-Box Transcription Factor 9) • YBX1 (Y-Box Binding Protein 1)
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    EGFR mutation
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    temozolomide
    12ms
    A Dual-Targeted Molecule for Disease-Activatable Proteolysis Targeting Chimeras and Targeted Radionuclide Therapy of Cancer. (PubMed, J Am Chem Soc)
    Additionally, the probe demonstrates high renal clearance, underscoring its biosafety for potential clinical translation. This study presents a potential approach for precise PROTACs combined with TRT for effective tumor therapy.
    Journal
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    RAD51 (RAD51 Homolog A) • RAD51AP1 (RAD51 Associated Protein 1) • BRD4 (Bromodomain Containing 4)