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    BIOMARKER:

    RAC1 deletion

    i
    Other names: RAC1, Rac Family Small GTPase 1, Ras-Related C3 Botulinum Toxin Substrate 1 (Rho Family, Small GTP Binding Protein Rac1), Ras-Related C3 Botulinum Toxin Substrate 1, Cell Migration-Inducing Gene 5 Protein, Ras-Like Protein TC25, P21-Rac1, MRD48, Rac-1, TC-25, MIG5, TC25
    Entrez ID:
    5879
    Related biomarkers:
    Mutation
    5ms
    The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes. (PubMed, EMBO Rep)
    HACE1 co-localizes with mTOR and RAC1, resulting in RAC1-dependent loss of mTOR protein stability. Together, our data demonstrate that HACE1 destabilizes mTOR by targeting RAC1 within mTOR-associated complexes, revealing a unique ubiquitin-dependent process to control the activity of mTOR signaling complexes.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • RAC1 (Rac Family Small GTPase 1) • UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5)
    |
    KRAS mutation • KRAS deletion • RAC1 deletion • KRAS expression
    3years
    HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner. (PubMed, Oncogene)
    An inverse relationship was observed between HACE1 and HIF1α levels in tumors compared to patient-matched normal kidney tissues, highlighting the potential pathophysiological significance of our findings. Together, our data uncover a previously unrecognized function for the HACE1 tumor suppressor in blocking HIF1α accumulation under hypoxia in a RAC1-dependent manner.
    Journal
    |
    KRAS (KRAS proto-oncogene GTPase) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • RAC1 (Rac Family Small GTPase 1)
    |
    HIF1A expression • RAC1 deletion