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    GENE:

    RAB10 (RAB10, Member RAS Oncogene Family)

    i
    Other names: RAB10, RAB10, Member RAS Oncogene Family, Ras-Related GTP-Binding Protein, Ras-Related Protein Rab-10, GTP-Binding Protein RAB10
    Associations

    News

    Trials
    28d
    Exosome RAB10 inhibits JAK1/STAT1 to hinder macrophage M1 polarization and promote tumor immune escape. (PubMed, Cell Commun Signal)
    RAB10 interacts with IFNAR1 to suppress the JAK1/STAT1 signaling pathway, thereby inhibiting M1 polarization and promoting M2 polarization of macrophages. Inhibition of RAB10, especially in combination with PD-L1 blockade, offers a promising strategy to enhance anti-tumor immunity and overcome therapeutic resistance in breast cancer.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    CD8 (cluster of differentiation 8) • JAK1 (Janus Kinase 1) • MMP2 (Matrix metallopeptidase 2) • VIM (Vimentin) • PCNA (Proliferating cell nuclear antigen) • STAT1 (Signal Transducer And Activator Of Transcription 1) • IFNAR1 (Interferon (alpha, beta and omega) receptor 1) • IFNAR2 (Interferon Alpha And Beta Receptor Subunit 2) • RAB10 (RAB10, Member RAS Oncogene Family)
    1m
    RAB10 mediates metabolic regulation of ferroptosis in breast Cancer and synergistically remodels the tumour immune microenvironment via macrophage M2 polarization. (PubMed, Int Immunopharmacol)
    This study investigates the potential role of the RAB10/PI3K/AKT/PPARγ axis in remodelling the breast cancer microenvironment from the perspective of metabolic-immune crosstalk. These findings not only enhance the understanding of the interplay between metabolism and immune responses in the tumour microenvironment but also provide a potential theoretical foundation and novel research directions for combination treatment strategies targeting this pathway.
    Journal
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    CD8 (cluster of differentiation 8) • PPARG (Peroxisome Proliferator Activated Receptor Gamma) • RAB10 (RAB10, Member RAS Oncogene Family)
    3ms
    Intracellular Transport of PD-L1 by Rab10-Positive Tubular Endosomes Originated from Macropinocytic Cups in RAW264 Macrophage-Like Cells. (PubMed, Acta Histochem Cytochem)
    This suggests that PD-L1 may be a significant cargo for these endosomes in macrophages. These findings offer new insights into the role of Rab10-positive tubular endosomes in the intracellular transport of PD-L1, potentially influencing its expression on the cell surface.
    Journal • PD(L)-1 Biomarker • IO biomarker
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    PD-L1 (Programmed death ligand 1) • RAB10 (RAB10, Member RAS Oncogene Family)
    5ms
    Integrated miRNA-mRNA Analyses of Triple-Negative Breast Cancer in Black and White Patients with or Without Obesity. (PubMed, Int J Mol Sci)
    Pathway enrichment analysis highlighted KRAS, ESR1, ESR2, RAB10, TNRC6C, and NCAN as the most commonly differentially expressed in EA, whereas ERBB4, PLCB1, and SERPINE1 were most frequently in AA. These findings highlight the importance of considering race-specific miRNA-mRNA signatures in understanding TNBC in the context of obesity, offering insights into biomarker-driven patient stratification for targeted therapeutic strategies.
    Journal
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    KRAS (KRAS proto-oncogene GTPase) • ER (Estrogen receptor) • ERBB4 (erb-b2 receptor tyrosine kinase 4) • SERPINE1 (Serpin Family E Member 1) • MIR143 (MicroRNA 143) • MIR424 (MicroRNA 424) • CDC25B (Cell Division Cycle 25B) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1) • MIR130A (MicroRNA 130a) • MIR148A (MicroRNA 148a) • MIR181B1 (MicroRNA 181b-1) • MIR195 (MicroRNA 195) • MIR204 (MicroRNA 204) • MIR30A (MicroRNA 30a) • NCBP1 (Nuclear Cap Binding Protein Subunit 1) • RAB10 (RAB10, Member RAS Oncogene Family)
    5ms
    [Retracted] miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10. (PubMed, Int J Mol Med)
    The Editor apologizes to the readership for any inconvenience caused. [International Journal of Molecular Medicine 42: 381‑391, 2018; DOI: 10.3892/ijmm.2018.3639].
    Journal
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    MIR378A (MicroRNA 378a) • RAB10 (RAB10, Member RAS Oncogene Family)
    6ms
    Bioinformatics Analysis Identifies Lipid Droplet-Associated Gene Signatures as Promising Prognostic and Diagnostic Models for Endometrial Cancer. (PubMed, Cancer Rep (Hoboken))
    This study provides the first comprehensive analysis of LDAGs in EC, establishing robust prognostic and diagnostic gene signatures with strong biological relevance. These signatures support a metabolism-driven framework for EC classification and may offer potential clinical utility in early detection, risk stratification, and personalized treatment.
    Journal • Gene Signature
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    ABCG1 (ATP Binding Cassette Subfamily G Member 1) • AIFM2 (Apoptosis Inducing Factor Mitochondria Associated 2) • LPCAT1 (Lysophosphatidylcholine Acyltransferase 1) • PRKAA2 (Protein Kinase AMP-Activated Catalytic Subunit Alpha 2) • RAB10 (RAB10, Member RAS Oncogene Family)
    7ms
    The molecular sub-type and the development and validation of a prognosis prediction model based on endocytosis-related genes for hepatocellular carcinoma. (PubMed, J Gastrointest Oncol)
    Genes linked to endocytosis strongly correlate with tumor classification in patients with HCC. The related expression profiles may be valuable for predicting HCC prognosis and informing diagnosis and treatment.
    Journal
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    CD4 (CD4 Molecule) • RAB10 (RAB10, Member RAS Oncogene Family) • HSPA8 (Heat Shock Protein Family A (Hsp70) Member 8)
    7ms
    Integrative proteomics and metabolomics analyses reveals the regulation of autophagy and ferroptosis by RAB10 through Slc37a2/mTOR pathway in breast cancer. (PubMed, Cell Mol Life Sci)
    Our study further confirmed that RAB10 mediates metabolic reprogramming in BC cells by regulating the Slc37a2/mTOR pathway, leading to enhanced autophagy and inhibition of ferroptosis. This comprehensive multi-omics analysis elucidated the key molecular and regulatory mechanisms underlying RAB10-induced metabolic reprogramming in tumors, providing potential new therapeutic targets and biomarkers for prognostic assessment in BC treatment.
    Journal • Metabolomic study
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    RAB10 (RAB10, Member RAS Oncogene Family)
    11ms
    Identification of a novel FOXO3‑associated prognostic model in hepatocellular carcinoma. (PubMed, Oncol Lett)
    Additionally, knockdown of RAB10, RAB7A and TAF3 inhibited proliferation of Huh7 cells, assessed by a Cell Counting Kit-8 assay. In conclusion, a novel FOXO3-related model was constructed and revealed that RAB10, RAB7A and TAF3 may be potential molecular targets or biomarkers for HCC.
    Journal
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    DDX5 (DEAD-Box Helicase 5) • FOXO3 (Forkhead box O3) • RAB10 (RAB10, Member RAS Oncogene Family)
    12ms
    Circular RNA ZNF277 Sponges miR-378d to Inhibit the Intracellular Survival of Mycobacterium tuberculosis by Upregulating Rab10. (PubMed, Cells)
    In summary, circ-ZNF277 inhibits the intracellular survival of Mtb via the miR-378d/Rab10 axis. This finding represents a novel mechanism of circular RNA in regulating host immune responses during Mtb infection.
    Journal
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    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • IL1B (Interleukin 1, beta) • RAB10 (RAB10, Member RAS Oncogene Family)
    12ms
    Layered Double Hydroxide LDH-Loaded miR-141-3p Targets RAB10 Suppressing Cellular Autophagy to Reverse Paclitaxel Resistance in Breast Cancer. (PubMed, ACS Omega)
    The bionanomaterial layered double hydroxide (LDH) is considered as an ideal gene delivery vehicle because of its nontoxicity, good biocompatibility, and slow drug release. According to our findings, we proved that miR-141-3p mediated breast cancer resistance to paclitaxel (PTX) by inhibiting autophagy through downregulation of RAB10, and LDH@miR-141-3p increased breast cancer cell sensitivity to PTX treatment, which provided a new idea for antitumor therapy.
    Journal
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    MIR141 (MicroRNA 141) • RAB10 (RAB10, Member RAS Oncogene Family)
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    paclitaxel
    1year
    Bioinformatics-Based Construction of Immune-Related microRNA and mRNA Prognostic Models for Hepatocellular Carcinoma. (PubMed, Cancer Manag Res)
    In addition, real-time quantitative PCR (RT-qPCR) results of the cell lines supported the results of the public database analysis. This study validated immune-related prognostic miRNAs and mRNAs and identified risk signatures for HCC, potentially advancing HCC prognosis and treatment.
    Journal
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    MIR223 (MicroRNA 223) • MIR424 (MicroRNA 424) • MIR145 (MicroRNA 145) • MIR150 (MicroRNA 150) • RAB10 (RAB10, Member RAS Oncogene Family)