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    GENE:

    R3HCC1 (R3H Domain And Coiled-Coil Containing 1)

    i
    Other names: R3HCC1, R3H Domain And Coiled-Coil Containing 1, R3H And Coiled-Coil Domain-Containing Protein 1, DKFZp564N123
    Associations

    News

    Trials
    almost2years
    Hypoxia-Challenged Pancreatic Adenocarcinoma Cell-Derived Exosomal circR3HCC1L Drives Tumor Growth Via Upregulating PKM2 Through Sequestering miR-873-5p. (PubMed, Mol Biotechnol)
    Also, PKM2 overexpression or miR-873-5p silencing offset circR3HCC1L knockdown-mediated effects on hypoxia-challenged PAAD cell malignant transformation and glycolysis. Hypoxic PAAD cell-derived exosomal circR3HCC1L facilitated PAAD progression through the miR-873-5p/PKM2 axis, highlighting the contribution of hypoxic PAAD cell-derived exosomal circR3HCC1L in PAAD.
    Journal
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    PKM (Pyruvate Kinase M1/2) • R3HCC1 (R3H Domain And Coiled-Coil Containing 1)
    over2years
    Identification of long noncoding RNAs with aberrant expression in prostate cancer metastases. (PubMed, Endocr Relat Cancer)
    In a cohort of prostatectomy-treated prostate tumors, four of the DE-lncRNAs showed association with progression-free time, and two of them (lnc-SCFD2-2, and lnc-R3HCC1L-8) were independent prognostic markers. Our study highlights several mCRPC-specific lncRNAs that might be important in the progression of the disease to the metastatic stage and may also serve as potential biomarkers for aggressive PCa.
    Journal
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    AR (Androgen receptor) • FOXA1 (Forkhead Box A1) • HOXB13 (Homeobox B13) • R3HCC1 (R3H Domain And Coiled-Coil Containing 1) • SCFD2 (Sec1 Family Domain Containing 2)