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    DRUG:

    Quadramet (samarium 153 lexidronam)

    i
    Other names: CYT 424
    Associations

    News

    Trials
    Company:
    Jazz
    Drug class:
    βγ radiation-emitting radionuclide
    Associations

    News

    Trials
    over2years
    Phase I evaluation of CycloSam (Sm-153-DOTMP) bone seeking radiopharmaceutical in dogs with spontaneous appendicular osteosarcoma. (PubMed, Vet Radiol Ultrasound)
    DOTMP (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene-phosphonate) is a macrocyclic chelating agent with superior binding properties to Sm when compared with EDTMP (Quadramet™, used for palliative treatment of bone cancer)...Carboplatin chemotherapy (300 mg/m2 IV every 3 weeks ×4) started 4 weeks after Sm-DOTMP injection...All dogs completed study monitoring. The recommended dose for CycloSam in dogs is 1.75 mCi/kg, which resulted in some pain control with minimal toxicity and was safely combined with chemotherapy.
    P1 data • Clinical Trial,Phase I • Journal
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    carboplatin • CycloSam (samarium-153 DOTMP) • Quadramet (samarium 153 lexidronam)