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    BIOMARKER:

    QKI-RAF1 fusion

    i
    Other names: QKI, QKI, KH Domain Containing RNA Binding, QK3, Protein Quaking, HqkI, Hqk, Homolog Of Mouse Quaking QKI (KH Domain RNA Binding Protein), Quaking Homolog, KH Domain RNA Binding (Mouse), Quaking Homolog, KH Domain RNA Binding, QKI/LOC100132735 Fusion, RNA Binding Protein HQK, QK1, HKQ, QK, RAF1, Raf-1 Proto-Oncogene Serine/Threonine Kinase, RAF Proto-Oncogene Serine/Threonine-Protein Kinase, V-Raf-1 Murine Leukemia Viral Oncogene Homolog 1, C-Raf Proto-Oncogene Serine/Threonine Kinase, Proto-Oncogene C-RAF, Raf-1, V-Raf-1 Murine Leukemia Viral Oncogene-Like Protein 1, Raf Proto-Oncogene Serine/Threonine Protein Kinase, Oncogene RAF1, CMD1NN, C-Raf, CRAF, CRaf, NS5, RAF
    Entrez ID:
    5894; 9444
    Related biomarkers:
    Mutation
    CNA
    Fusion
    11ms
    Fusion Detection in Primary Neoplasms of the CNS Using the TSO500 NGS RNA/DNA Hybrid Panel (AANP 2023)
    In addition to common partners (e.g. KIAA1549 for BRAF) we detected less common partners to BRAF including GTF21 as well as less common partners for MET and NTRK2 fusions in glioma. Future studies are needed to determine the full diagnostic utility and therapeutic implications of expanded fusion detection.
    Next-generation sequencing
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    BRAF (B-raf proto-oncogene) • FGFR2 (Fibroblast growth factor receptor 2) • FGFR3 (Fibroblast growth factor receptor 3) • FGFR1 (Fibroblast growth factor receptor 1) • NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • TACC3 (Transforming acidic coiled-coil containing protein 3) • KIAA1549 • CAPZA2 (Capping Actin Protein Of Muscle Z-Line Subunit Alpha 2) • SHTN1 (Shootin 1) • PTPRZ1 (Protein Tyrosine Phosphatase Receptor Type Z1)
    |
    NTRK2 fusion • FGFR2 fusion • KIAA1549-BRAF fusion • FGFR1 fusion • FGFR3 fusion • QKI-RAF1 fusion
    |
    TruSight Oncology 500 Assay