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DRUG:

Qapzola (apaziquone)

i
Other names: EO9, NOR 701, NSC 382459
Associations
Trials
Company:
Assertio
Drug class:
DNA cross linking agent
Associations
Trials
2years
Development of Hif1a Pharmacogenomic Mutation Models to Study Individual Variations in Drug Action for Tumor Hypoxia: An in Silico Approach. (PubMed, J Pharm Bioallied Sci)
Potential models were used for interaction studies with hypoxia-specific molecules (tirapazamine, apaziquone, and ENMD) using docking analysis. It also elucidates that the therapeutic effect is altered concerning population-dependent genetic changes in the individual. The study, therefore, asserts the need to set up a personalized drug design approach to enhance tumor hypoxia treatment efficacy.
Journal
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HIF1A (Hypoxia inducible factor 1, alpha subunit)
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Qapzola (apaziquone) • Tirazone (tirapazamine)