Q-Force (quercetin)

The most prevalent anti-cancer therapies used were lenvatinib (75% pts exposed) and nivolumab (73% pts) and the most prevalent regimen was gemcitabine/lenvatinib/oxaliplatin (33% of pts). Among repurposed agents, 50% were exposed to quercetin, 44% to celecoxib, and 14% to metformin... Patients with FLC undergo extensive molecular profiling with multiple novel therapeutic regimens being employed in real world practice. Aggregation of raw imaging scans is ongoing for central radiological review to measure depth and duration of response offered by the recorded therapeutic strategies. This dataset is a rich resource available to academic and government researchers to fuel research and define optimal treatment modalities.

P2, N=30, Recruiting, Temple University | Not yet recruiting --> Recruiting

PIM2 kinase regulates NK cell anti-myeloma activity by modulating TIGIT expression and energy metabolism.

In addition, SOD, GPX, GSR, HO-1, and Nrf2 showed decreased expression at 50 – 250 µM quercetin and OTA at IC50 value. These results suggest that quercetin may alleviate potential OTA-induced liver damage and oxidative stress through reducing cytotoxicity and enhancing the cellular antioxidant defense systems.

Kaempferol and Quercetin Dihydrate inhibit proliferation and induce apoptosis of myeloid neoplasms cells. PIM2 is an important target for the development and prognosis of acute myeloid leukemia and MDS. Kaempferol and Quercetin Dihydrate inhibit PIM2 kinase in myeloid neoplasms cells and subsequently participate in NF-κB expression, proliferation and regulation of myeloid neoplasms.

PIM2 kinase regulates NK cell anti-myeloma activity by modulating TIGIT expression and energy metabolism.Figure A.PIM2 was over expressed on NK cells from MM patients, the PIM2 kinase inhibitor improved NK cells function and decreased the expression of TIGIT. B.PIM2 kinase increased TIGIT expression on NK cell surface by up- regulated ETS-1. C.

Senolytics, such as the cocktail quercetin plus dasatinib (D+Q), show impressive effects in experimental models of pulmonary fibrosis... SOC drugs failed to trigger apoptosis in IPF senescent fibroblasts, nintedanib enhanced Bcl-2 levels and pirfenidone triggered the activation of the necroptosis pathway. SOC drugs elevated fibrotic and senescence markers in IPF lung fibroblasts. Together, these data demonstrated the inefficacy of SOC in targeting senescent cells in IPF.Funding: Cedars-Sinai Medical Center

The reduction of SULT1A1 mediated sulfonation of Tamoxifen-metabolites and Fulvestrant in the presence of these inhibitors was assessed using DESI-MS...The structures of each SULT1A1-inhibitor complex were determined to 1.27 Å and 1.51 Å resolution respectively. These high-resolution co-crystal structures facilitate the exploration of the inhibitor binding site for the structure-based design of more potent inhibitors against SULT1A1.

Tumor cell senescence was determined by the cells’ morphology. Expression of biomarkers for senescence in tumor tissues were determined by senescence associated β-galactosidase (SA-β-Gal) assay, DNA damage (53BP1/ γ-H2AX foci), and qRT-PCR analysis for p21 and p16 genes, and SASP including IL-1b, IL-6, IL-8, TGF-b, TNF-

Pretreatment or co-incubation with PDI inhibitors also significantly reduced cellular TF activation by antithymocyte globulin or daunorubicin, indicating that downregulation of TF antigen was mainly restricted to the cryptic pool of TF... Our study indicates a complex role for PDI in the regulation of myeloid TF, which includes downregulation of both inducible and constitutive TF production. Thus, targeting PDI might be a promising strategy to prevent or treat AML-associated coagulopathies.

Legal entity responsible for the study: The authors. Funding: UGM.

Butterfly pea flower extract has an antimetastatic activity to MCF-7 HER2-positive breast cancer cell line in-vitro. UGM.

Butterfly pea flower extract has an antimetastatic activity to MCF-7 HER2-positive breast cancer cell line in-vitro. UGM.