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    GENE:

    PXDNL (Peroxidasin Like)

    i
    Other names: PXDNL, Peroxidasin Like, Peroxidasin-Like Protein, Vascular Peroxidase 2, Cardiac Peroxidase, PRM1, VPO2, Polysomal Ribonuclease 1 Homolog (Xenopus), Peroxidasin Homolog-Like (Drosophila), Peroxidasin Homolog (Drosophila)-Like, Polysomal Ribonuclease 1 Homolog, Cardiovascular Peroxidase 2, Peroxidasin Homolog-Like, Polysomal Ribonuclease 1, PMR1
    10ms
    Upregulated PXDNL promotes invasive breast carcinoma progression. (PubMed, Am J Transl Res)
    Overexpression of PXDNL is associated with poor prognosis and is linked to immune cell infiltration in BRCA. Thus, PXDNL may be a biomarker or therapeutic target for BRCA.
    Journal • BRCA Biomarker
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    CD8 (cluster of differentiation 8) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • BRCA (Breast cancer early onset) • PXDNL (Peroxidasin Like)
    almost2years
    Development of a Prognostic Risk Model Based on Oxidative StressRelated Genes for Platinum-Resistant Ovarian Cancer Patients. (PubMed, Recent Pat Anticancer Drug Discov)
    The OSRGs-based risk score model can efficiently predict the prognosis and platinum resistance of OC patients. This model may improve the risk stratification of OC patients in the clinic.
    Journal
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    WRN (WRN RecQ Like Helicase) • PXDNL (Peroxidasin Like) • SPHK1 (Sphingosine Kinase 1)
    almost2years
    Molecular analysis of apocrine mixed tumors and cutaneous myoepitheliomas: a comparative study confirming a continuous spectrum of one entity with near-ubiquitous PLAG1 and rare mutually exclusive HMGA2 gene rearrangements. (PubMed, Virchows Arch)
    In addition, we identified a novel PXDNL::PLAG1 fusion and suggested that rare cases may harbor HMGA2 gene alterations which seem to be mutually exclusive with PLAG1 gene fusions. The relatedness of these tumors to salivary gland myoepithelial neoplasms and distinctness from eccrine mixed tumors and other skin and soft tissue myoepithelial neoplasms with EWSR1/FUS fusions is discussed.
    Journal
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    CTNNB1 (Catenin (cadherin-associated protein), beta 1) • EWSR1 (EWS RNA Binding Protein 1) • FUS (FUS RNA Binding Protein) • HMGA2 (High mobility group AT-hook 2) • NDRG1 (N-Myc Downstream Regulated 1) • PLAG1 (PLAG1 Zinc Finger) • PXDNL (Peroxidasin Like) • TRPS1 (Transcriptional Repressor GATA Binding 1)
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    HMGA2 expression
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    FusionPlex® Dx
    almost3years
    Novel Implication of the Basement Membrane for Breast Cancer Outcome and Immune Infiltration. (PubMed, Int J Biol Sci)
    More importantly, a strongly positive correlation between the BMscore and EMT activity was revealed with immunohistochemistry and in vitro experiments. Taken together, we provided a novel BMscore gene signature for breast cancer patients to predict clinical prognosis and metastasis accurately, which may help with individualized clinical decision-making.
    Journal • BRCA Biomarker
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    BRCA (Breast cancer early onset) • SDC1 (Syndecan 1) • PXDNL (Peroxidasin Like)
    almost3years
    Identifying tumour microenvironment-related signature that correlates with prognosis and immunotherapy response in breast cancer. (PubMed, Sci Data)
    Upregulation of PXDNL and LINC02038 and downregulation of SLC27A2, KLRB1, IGHV1-12 and IGKV1OR2-108 in high-risk score group synergistically contribute to immunosuppressive microenvironment which characterized by immunosuppressive neutrophils, impaired cytotoxic T lymphocytes migration and natural killer cell cytotoxicity. In summary, we identified a TME-related prognostic signature in BRCA, which was connected with immune cell infiltration, immune checkpoints, immunotherapy response and could be developed for immunotherapy targets.
    Journal • Tumor mutational burden • BRCA Biomarker • IO biomarker
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    TMB (Tumor Mutational Burden) • BRCA (Breast cancer early onset) • PXDNL (Peroxidasin Like) • KLRB1 (Killer Cell Lectin Like Receptor B1)
    3years
    PXDNL activates the motility of urothelial bladder carcinoma cells through the Wnt/β-catenin pathway and has a prognostic value. (PubMed, Life Sci)
    The results reveal a novel molecular target that could be further explored for developing preventive, predictive, and individualized treatment strategies for UCB.
    Journal
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    PXDNL (Peroxidasin Like)