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    DRUG CLASS:

    Purinergic receptor P2Y12 inhibitor

    Related drugs:
    3d
    TIMO: Ticagrelor Monotherapy After Stenting (clinicaltrials.gov)
    P2, N=200, Recruiting, Vastra Gotaland Region | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Mar 2024 --> Sep 2025
    Trial completion date • Trial primary completion date
    8d
    3rd Generation Resorbable Magnesium Scaffolds vs Biodegradable Polymer Stents in NSTE/ACS (clinicaltrials.gov)
    P4, N=220, Not yet recruiting, Konstantinos Toutouzas
    New P4 trial
    11d
    Clopidogrel Versus Cilostazol on Vessels (clinicaltrials.gov)
    P4, N=120, Recruiting, Seoul National University Bundang Hospital
    New P4 trial
    23d
    A Study to Evaluate the Impact of 11-month Ticagrelor Monotherapy Following One-month DAPT After PCI (clinicaltrials.gov)
    P=N/A, N=0, Withdrawn, Sino Medical Sciences Technology Inc. | N=285 --> 0 | Not yet recruiting --> Withdrawn
    Enrollment change • Trial withdrawal • Real-world evidence • Real-world
    23d
    LV Thrombus After Acute AMI: A Randomized Controlled Trial (clinicaltrials.gov)
    P=N/A, N=25, Terminated, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N=250 --> 25 | Unknown status --> Terminated
    Enrollment change • Trial termination
    25d
    Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention (clinicaltrials.gov)
    P4, N=50, Recruiting, University of Florida | Not yet recruiting --> Recruiting
    Enrollment open
    26d
    SMART-CHOICEII: P2Y12 Inhibitor Monotherapy Versus Extended DAPT in Patients Treated With Bioresorbable Scaffold (clinicaltrials.gov)
    P4, N=25, Terminated, Samsung Medical Center | N=1520 --> 25 | Suspended --> Terminated; cannot use bioabsorbable scaffold
    Enrollment change • Trial termination
    1m
    NIA-SCORE: NeuroCognition After Carotid Recanalization (clinicaltrials.gov)
    P2, N=33, Completed, Duke University | Active, not recruiting --> Completed
    Trial completion
    1m
    Combining Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Large-vessel Ischemic Stroke (clinicaltrials.gov)
    P3, N=600, Recruiting, Kafrelsheikh University
    New P3 trial
    |
    atorvastatin
    1m
    Concomitant Use of Clopidogrel With Atorvastatin or Rosuvastatin in Patients With Minor Stroke or TIA (clinicaltrials.gov)
    P3, N=600, Recruiting, Kafrelsheikh University
    New P3 trial
    |
    atorvastatin
    1m
    APS-STROKE: Comparison of Clopidogrel-based Antiplatelet Therapy Versus Warfarin as Secondary Prevention Strategy for AntiPhospholipid Syndrome-related STROKE (clinicaltrials.gov)
    P4, N=400, Recruiting, Seoul National University Hospital | Not yet recruiting --> Recruiting
    Enrollment open
    1m
    OPTIMUS-7: Ticagrelor With and Without Aspirin in Patients With Diabetes Mellitus (clinicaltrials.gov)
    P4, N=105, Active, not recruiting, University of Florida | Recruiting --> Active, not recruiting | N=63 --> 105 | Trial primary completion date: May 2024 --> Jan 2024
    Enrollment closed • Enrollment change • Trial primary completion date
    2ms
    Ticagrelor Versus Cilostazol in Large-vessel Ischemic Stroke (clinicaltrials.gov)
    P3, N=580, Recruiting, Kafrelsheikh University | Trial completion date: Mar 2024 --> Jul 2024 | Trial primary completion date: Feb 2024 --> Jun 2024
    Trial completion date • Trial primary completion date
    2ms
    SWAP-6: Pharmacodynamic and Pharmacokinetic of Switching From Cangrelor to Prasugrel in ACS Patients Undergoing PCI (clinicaltrials.gov)
    P4, N=359, Completed, University of Florida | N=77 --> 359
    Enrollment change
    2ms
    TAPIS: Ticagrelor With Aspirin Dual Antiplatelet Therapy Combined With Intravenous Thrombolysis for Ischemic Stroke (clinicaltrials.gov)
    P3, N=1380, Not yet recruiting, Beijing Tiantan Hospital
    New P3 trial
    2ms
    DOSE: Randomized Comparison of Radiation Exposure to Operators in Coronary Intervention Between Right Radial and Left DRA (clinicaltrials.gov)
    P=N/A, N=1010, Recruiting, Yonsei University | Trial primary completion date: Sep 2025 --> Dec 2025
    Trial primary completion date
    2ms
    SAC-TIDE: Stent-Assisted Coiling Followed by Ticagrelor Monotherapy Instead of Dual Antiplatelet Therapy in Unruptured Intracranial Aneurysm (clinicaltrials.gov)
    P=N/A, N=180, Recruiting, The First Affiliated Hospital with Nanjing Medical University | Not yet recruiting --> Recruiting | Initiation date: Sep 2023 --> Jan 2024
    Enrollment open • Trial initiation date
    3ms
    BRLCEIACS/OMI: Brilinta Clinical Experience Investigation (clinicaltrials.gov)
    P=N/A, N=566, Active, not recruiting, AstraZeneca | Recruiting --> Active, not recruiting | N=1750 --> 566
    Enrollment closed • Enrollment change
    3ms
    The Effect of Clopidogrel and Ticagrelor on Human Adipose Mesenchymal Stem Cell Osteogenic Differentiation Potential: In Vitro Comparative Study. (PubMed, Adv Pharmacol Pharm Sci)
    Conclusion. TICA may possess a positive effect on hAd-MSCs osteogenic differentiation compared to CLP.
    Preclinical • Journal
    |
    IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • RUNX2 (RUNX Family Transcription Factor 2) • TNFRSF11B (Tumor necrosis factor receptor superfamily member 11B)
    |
    IL6 expression
    3ms
    ODIN: One-Month DAPT in CABG Patients (clinicaltrials.gov)
    P3, N=700, Not yet recruiting, Weill Medical College of Cornell University | Initiation date: Jan 2024 --> Oct 2024
    Trial initiation date
    3ms
    1-month vs 12-month DAPT for ACS Patients Who Underwent PCI Stratified by IVUS: IVUS-ACS and ULTIMATE-DAPT Trials (clinicaltrials.gov)
    P=N/A, N=3710, Active, not recruiting, Nanjing First Hospital, Nanjing Medical University | Trial completion date: Sep 2024 --> Dec 2025
    Trial completion date
    3ms
    CAMEO: Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry (clinicaltrials.gov)
    P=N/A, N=4000, Recruiting, Chiesi USA, Inc. | Trial completion date: Oct 2023 --> Oct 2024 | Trial primary completion date: Oct 2023 --> Oct 2024
    Trial completion date • Trial primary completion date
    3ms
    Clopidogrel Versus Cilostazol in Ischemic Stroke (clinicaltrials.gov)
    P3, N=900, Recruiting, Kafrelsheikh University
    New P3 trial
    3ms
    Clopidogrel Versus Cilostazol in Large-vessel Ischemic Stroke (clinicaltrials.gov)
    P3, N=580, Recruiting, Kafrelsheikh University
    New P3 trial
    3ms
    Safety of Cold Snare Polypectomy in Patients With Uninterrupted Antiplatelet Agent (clinicaltrials.gov)
    P=N/A, N=314, Completed, Incheon St.Mary's Hospital | Unknown status --> Completed
    Trial completion
    4ms
    Effects of Low-dose Ticagrelor vs. Clopidogrel in Stable Patients Undergoing Elective Percutaneous Coronary Intervention (clinicaltrials.gov)
    P4, N=50, Not yet recruiting, University of Florida
    New P4 trial
    4ms
    Pharmacodynamic Outcomes in CCS Patients Treated With an Individualized Treatment Strategy (clinicaltrials.gov)
    P4, N=88, Recruiting, St. Antonius Hospital | Not yet recruiting --> Recruiting | Initiation date: Jul 2023 --> Jan 2024
    Enrollment open • Trial initiation date
    4ms
    FACTPCI: Fentanyl and Crushed Ticagrelor in Percutaneous Coronary Intervention (clinicaltrials.gov)
    P4, N=80, Recruiting, The Guthrie Clinic | Trial completion date: Dec 2024 --> Dec 2025 | Trial primary completion date: Dec 2023 --> Dec 2024
    Trial completion date • Trial primary completion date
    4ms
    MATRIX-2: Monotherapy With P2Y12 Inhibitors in Patients With Atrial fIbrillation Undergoing Supraflex Stent Implantation (clinicaltrials.gov)
    P4, N=3010, Recruiting, Insel Gruppe AG, University Hospital Bern | Not yet recruiting --> Recruiting | Phase classification: P3 --> P4 | Initiation date: Sep 2023 --> Dec 2023
    Enrollment open • Phase classification • Trial initiation date
    4ms
    POLY-ACS: Polypill in Acute Coronary Syndrome (clinicaltrials.gov)
    P2, N=80, Recruiting, University of Texas Southwestern Medical Center | N=60 --> 80 | Trial completion date: Nov 2023 --> Jul 2024 | Trial primary completion date: Nov 2023 --> May 2024
    Enrollment change • Trial completion date • Trial primary completion date
    4ms
    Ticagrelor Versus Cilostazol in Large-vessel Ischemic Stroke (clinicaltrials.gov)
    P3, N=580, Recruiting, Kafrelsheikh University
    New P3 trial
    4ms
    Ticagrelor Versus Cilostazol in Minor Ischemic Stroke or TIA (clinicaltrials.gov)
    P3, N=900, Recruiting, Kafrelsheikh University
    New P3 trial
    5ms
    APS-STROKE: Comparison of Clopidogrel-based Antiplatelet Therapy Versus Warfarin as Secondary Prevention Strategy for AntiPhospholipid Syndrome-related STROKE (clinicaltrials.gov)
    P4, N=400, Not yet recruiting, Seoul National University Hospital
    Trial completion date • Trial initiation date • Trial primary completion date
    5ms
    Photothermal Responsive Microcarriers Encapsulated With Cangrelor and 5-Fu for Colorectal Cancer Treatment. (PubMed, Small Methods)
    In vivo studies validate that the G-M@F/C+NIR microcarriers significantly inhibites tumor growth, decreased the expression of Ki-67 in tumor cells and vascular endothelial growth factor (VEGF) in the tumor microenvironment, while increased the expression of E-cadherin. It is believe that by means of the proposed photothermal responsive microcarriers, the synergistic strategy of platelet inhibition, chemotherapy, and photothermal therapy can find practical applications in cancer treatment.
    Journal
    |
    CDH1 (Cadherin 1)
    |
    CDH1 expression
    |
    5-fluorouracil
    5ms
    Multimarker Evaluation of Platelet Activity and Agregation in ACS (clinicaltrials.gov)
    P=N/A, N=150, Completed, Medical University of Warsaw
    New trial
    5ms
    SOS-AMI: Selatogrel Outcome Study in Suspected Acute Myocardial Infarction (clinicaltrials.gov)
    P3, N=14000, Enrolling by invitation, Idorsia Pharmaceuticals Ltd.
    Trial completion date • Trial primary completion date
    5ms
    Ticagrelor Versus Clopidogrel in Large Vessel Ischemic Stroke (clinicaltrials.gov)
    P3, N=580, Completed, Kafrelsheikh University | Recruiting --> Completed
    Trial completion
    5ms
    Anti-Platelets in Chronic Obstructive Pulmonary Disease (clinicaltrials.gov)
    P2, N=30, Recruiting, Brigham and Women's Hospital | Not yet recruiting --> Recruiting | Trial completion date: Aug 2024 --> Jun 2025 | Trial primary completion date: May 2024 --> Dec 2024
    Enrollment open • Trial completion date • Trial primary completion date
    |
    VEGFA (Vascular endothelial growth factor A) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • TIMP1 (Tissue inhibitor of metalloproteinases 1) • MPO (Myeloperoxidase)
    5ms
    Antiplatelet Effects of Tirofiban vs. Cangrelor N-STEMI Patients Undergoing Percutaneous Coronary Intervention (clinicaltrials.gov)
    P=N/A, N=10, Terminated, Inova Health Care Services | N=60 --> 10 | Unknown status --> Terminated; study terminated per PI
    Enrollment change • Trial termination
    6ms
    P2Y12 Inhibitor-based SAPT Versus Conventional DAPT After PCI With BioFreedom Ultra Drug-coated Stent for Unprotected Left Main Disease (ULTRA-LM) (clinicaltrials.gov)
    P=N/A, N=766, Not yet recruiting, IGLESIAS Juan Fernando | Trial completion date: Dec 2027 --> Dec 2028 | Initiation date: May 2023 --> May 2024 | Trial primary completion date: May 2027 --> May 2028
    Trial completion date • Trial initiation date • Trial primary completion date
    6ms
    STARS DAPT: STEMI Treated With a Polymer-free Sirolimus-coated Stent and P2Y12 Inhibitor-based SAPT Versus Conventional DAPT (clinicaltrials.gov)
    P=N/A, N=350, Not yet recruiting, IGLESIAS Juan Fernando | Trial completion date: Dec 2024 --> Dec 2026 | Initiation date: Jun 2023 --> Jun 2024 | Trial primary completion date: Jun 2024 --> Jun 2025
    Trial completion date • Trial initiation date • Trial primary completion date