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BIOMARKER:

PTTG1 overexpression

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Other names: PTTG1, Pituitary Tumor-transforming 1, EAP1, TUTR1
Entrez ID:
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Trials
7ms
Clinical significance and potential regulatory mechanism of overexpression of pituitary tumor-transforming gene transcription factor in bladder cancer. (PubMed, BMC Cancer)
PTTG1 mRNA over-expression may become a potential biomarker for BLCA prognosis. Additionally, PTTG1 may correlate with the BLCA tumor microenvironment and exert transcriptional activity by targeting CHEK2, OCIAD2, UBE2L3, and ZNF367 in BLCA tissue.
Journal
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CHEK2 (Checkpoint kinase 2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin)
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PTTG1 overexpression
11ms
A Comprehensive Pan-Cancer Analysis for Pituitary Tumor-Transforming Gene 1. (PubMed, Front Genet)
Additionally, PTTG1 is related to immune infiltration, immune checkpoints, tumor mutational burden, and microsatellite instability. Thus, PTTG1 could be potential biomarker for both prognosis and outcomes of tumor treatment and it could also be a promising target in tumor therapy.
Journal • Tumor Mutational Burden • Pan tumor
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TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin)
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PTTG1 overexpression
over1year
SP1-mediated transcriptional activation of PTTG1 regulates the migration and phenotypic switching of aortic vascular smooth muscle cells in aortic dissection through MAPK signaling. (PubMed, Arch Biochem Biophys)
SP1 transcriptional activation of PTTG1 activated MAPK/ERK signaling pathway. In conclusion, SP1 transcriptional activation of PTTG1 regulates the migration and phenotypic transformation of HAVSMCs in AD by MAPK Signaling.
Journal
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SPP1 (Secreted Phosphoprotein 1) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • TAGLN (Transgelin)
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PTTG1 overexpression