^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    BIOMARKER:

    PTTG1 overexpression

    i
    Other names: PTTG1, Pituitary Tumor-transforming 1, EAP1, TUTR1
    Entrez ID:
    9232
    1m
    Upregulated expression of PTTG1 is associated with progression of pancreatic cancer. (PubMed, J Gastrointest Oncol)
    The four identified core genes were CDK1, CCNA2, CDC20, and MAD2L1. The upregulated expression of PTTG1 plays an essential role in PC's progression as a biomarker.
    Journal
    |
    CCNA2 (Cyclin A2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • CDC20 (Cell Division Cycle 20) • CDK1 (Cyclin-dependent kinase 1) • MAD2L1 (Mitotic Arrest Deficient 2 Like 1)
    |
    PTTG1 overexpression
    2ms
    PTTG1 induces pancreatic cancer cell proliferation and promotes aerobic glycolysis by regulating c-myc. (PubMed, Open Life Sci)
    In Mia-PaCa2 cells, PTTG1 overexpression promoted cell proliferation, aerobic glycolysis, and translocation of β-catenin to the nucleus by regulating c-myc. In conclusion, PTTG1 induces proliferation, migration, and invasion, and promotes aerobic glycolysis in pancreatic cancer cells via regulating c-myc, demonstrating the potential of PTTG1 as a therapeutic target.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • CDH1 (Cadherin 1) • CDH2 (Cadherin 2) • PCNA (Proliferating cell nuclear antigen) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin)
    |
    MYC expression • CDH1 expression • PTTG1 overexpression
    9ms
    PTTG1 reprograms asparagine metabolism to promote hepatocellular carcinoma progression. (PubMed, Cancer Res)
    Furthermore, HBx promoted ASNS and asparagine metabolism by upregulating PTTG1 expression. Overall, PTTG1 is involved in the reprogramming of asparagine metabolism to promote HCC progression and may serve as a therapeutic and diagnostic target for HCC.
    Journal
    |
    ASNS (Asparagine synthetase) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin)
    |
    PTTG1 overexpression
    12ms
    PTTG1 promotes CD34CD45 cells to repair the pulmonary vascular barrier via activating the VEGF-bFGF/PI3K/AKT/eNOS signaling pathway in rats with phosgene-induced acute lung injury. (PubMed, Biomed Pharmacother)
    Moreover, LY294002 (PI3K inhibitor) treatment inhibited the endothelial differentiation of CD34CD45 cells, while SC79 (AKT activator) yielded the opposite effect. These findings suggest that PTTG1 can promote the endothelial differentiation of CD34CD45 cells by activating the VEGF-bFGF/PI3K/AKT/eNOS signaling pathway, leading to the repair of the pulmonary vascular barrier in rats with P-ALI.
    Preclinical • Journal
    |
    PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • NOS3 (Nitric oxide synthase 3)
    |
    PTTG1 overexpression
    |
    LY294002
    1year
    PTTG1 alleviates acute alcoholic liver injury by inhibiting endoplasmic reticulum stress-induced hepatocyte pyroptosis. (PubMed, Liver Int)
    We demonstrated that PTTG1 participates in ALI and has a protective effect against alcohol-induced hepatic ER stress and pyroptosis.
    Journal
    |
    PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin)
    |
    PTTG1 overexpression
    almost2years
    Clinical significance and potential regulatory mechanism of overexpression of pituitary tumor-transforming gene transcription factor in bladder cancer. (PubMed, BMC Cancer)
    PTTG1 mRNA over-expression may become a potential biomarker for BLCA prognosis. Additionally, PTTG1 may correlate with the BLCA tumor microenvironment and exert transcriptional activity by targeting CHEK2, OCIAD2, UBE2L3, and ZNF367 in BLCA tissue.
    Journal
    |
    CHEK2 (Checkpoint kinase 2) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin)
    |
    PTTG1 overexpression
    2years
    A Comprehensive Pan-Cancer Analysis for Pituitary Tumor-Transforming Gene 1. (PubMed, Front Genet)
    Additionally, PTTG1 is related to immune infiltration, immune checkpoints, tumor mutational burden, and microsatellite instability. Thus, PTTG1 could be potential biomarker for both prognosis and outcomes of tumor treatment and it could also be a promising target in tumor therapy.
    Journal • Tumor Mutational Burden • Pan tumor
    |
    TMB (Tumor Mutational Burden) • MSI (Microsatellite instability) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin)
    |
    PTTG1 overexpression
    over2years
    SP1-mediated transcriptional activation of PTTG1 regulates the migration and phenotypic switching of aortic vascular smooth muscle cells in aortic dissection through MAPK signaling. (PubMed, Arch Biochem Biophys)
    SP1 transcriptional activation of PTTG1 activated MAPK/ERK signaling pathway. In conclusion, SP1 transcriptional activation of PTTG1 regulates the migration and phenotypic transformation of HAVSMCs in AD by MAPK Signaling.
    Journal
    |
    SPP1 (Secreted Phosphoprotein 1) • PTTG1 (PTTG1 Regulator Of Sister Chromatid Separation, Securin) • TAGLN (Transgelin)
    |
    PTTG1 overexpression