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    BIOMARKER:

    PTPRT overexpression

    i
    Other names: Receptor Protein Tyrosine Phosphatase, Receptor-Type Tyrosine-Protein Phosphatase T, PTPRT, Protein Tyrosine Phosphatase Receptor Type T, Receptor-Type Tyrosine-Protein Phosphatase Rho
    Entrez ID:
    11122
    Related biomarkers:
    Mutation
    Others
    11d
    System analysis based on T-cell exhaustion-related genes identifies PTPRT as a promising diagnostic and prognostic biomarker for gastric cancer. (PubMed, Sci Rep)
    In addition, flow cytometry revealed that PTPRT overexpression alleviated TEX by increasing the abundance of CD8+ T cells, with inhibition of cell surface PD-1 and Tim-3. The predictive prognostic value of TEX gene expression levels was evaluated in patients with gastric cancer, providing a new perspective for precision immuno-oncology studies.
    Journal • PD(L)-1 Biomarker • IO biomarker
    |
    CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • PTPRT (Protein tyrosine phosphatase receptor type T) • CAV2 (Caveolin 2)
    |
    PTPRT overexpression
    8ms
    Downregulation of PTPRT elevates the expression of survivin and promotes the proliferation, migration, and invasion of lung adenocarcinoma. (PubMed, BMC Cancer)
    Our findings uncovered the essential roles of PTPRT in the regulation of proliferation, migration, and invasion of LUAD, and highlighted the clinical significance of PTPRT downregulation in lung cancer.
    Journal • Tumor mutational burden • IO biomarker
    |
    TMB (Tumor Mutational Burden) • BIRC5 (Baculoviral IAP repeat containing 5) • PTPRT (Protein tyrosine phosphatase receptor type T) • CDCA3 (Cell Division Cycle Associated 3)
    |
    BIRC5 expression • PTPRT mutation • PTPRT overexpression