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GENE:

PTPRK (Protein Tyrosine Phosphatase Receptor Type K)

News alerts, weekly reports and conference planners

Identification of potentially deleterious mutations in gastric cancer using patient-derived xenograft models. (PubMed, Front Genet)

The integrated analysis of longitudinal WES data from primary tumors and matched PDXs enabled the identification of a core set of conserved, potentially deleterious mutations. The four prioritized mutations (PTPRK, PIK3CB, LRP1B, and IGF2R) provide new insights into the genetic landscape of gastric cancer and represent promising candidates for the development of targeted therapeutic strategies.

7 days ago

Preclinical • Journal

TP53 (Tumor protein P53) • ASXL1 (ASXL Transcriptional Regulator 1) • LRP1B (LDL Receptor Related Protein 1B) • PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • PIK3CB (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) • IRS2 (Insulin receptor substrate 2) • ERCC5 (ERCC Excision Repair 5 Endonuclease 2) • PDE4DIP (Phosphodiesterase 4D Interacting Protein) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K)

TP53 mutation • ASXL1 mutation

23d

Bile duct tumor thrombus (intraductal polypoid growth)-positive intrahepatic cholangiocarcinoma: clinicopathologic and genomic analysis. (PubMed, J Pathol)

These results highlight the importance of evaluating BDTT in SDT, as it may be the main route of hilar extension in aggressive cases.

23 days ago

Journal

KRAS (KRAS proto-oncogene GTPase) • BRAF (B-raf proto-oncogene) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • NRAS (Neuroblastoma RAS viral oncogene homolog) • FGFR2 (Fibroblast growth factor receptor 2) • IDH1 (Isocitrate dehydrogenase (NADP(+)) 1) • IDH2 (Isocitrate Dehydrogenase (NADP(+)) 2) • ARID1A (AT-rich interaction domain 1A) • NF1 (Neurofibromin 1) • BAP1 (BRCA1 Associated Protein 1) • KMT2D (Lysine Methyltransferase 2D) • MUC1 (Mucin 1) • SMAD4 (SMAD family member 4) • MLL2 (Myeloid/lymphoid or mixed-lineage leukemia 2) • TGFBR2 (Transforming Growth Factor Beta Receptor 2) • MUC4 (Mucin 4, Cell Surface Associated) • CDX2 (Caudal Type Homeobox 2) • MUC2 (Mucin 2) • RSPO3 (R-Spondin 3) • CACNA1A (Calcium Voltage-Gated Channel Subunit Alpha1 A) • MUC17 (Mucin 17) • MUC5AC (Mucin 5AC) • MUC6 (Mucin 6) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • TGFBR1 (Transforming Growth Factor Beta Receptor 1)

FGFR2 mutation • FGFR2 fusion • FGFR2 rearrangement

3ms

RSPO3 rearrangements in advanced colorectal cancer patients and their relationship with disease characteristics. (PubMed, World J Gastrointest Oncol)

This study identifies a relatively high incidence of RSPO3 rearrangements in aCRC and a strong association with clinical features. Furthermore, we find that RSPO3 fusions are associated with poorer OS.

3 months ago

Journal

TP53 mutation

9ms

Mutational and expression analysis of classical protein tyrosine phosphatase genes in pancreatic ductal adenocarcinoma. (PubMed, Comput Biol Med)

These findings hold particular relevance for the Pakistani population, offering valuable insights into the genetic landscape of this aggressive cancer.

9 months ago

Journal

PTPN12 (Protein Tyrosine Phosphatase Non-Receptor Type 12) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • PTPRZ1 (Protein Tyrosine Phosphatase Receptor Type Z1)

10ms

Protein tyrosine phosphatase receptor type kappa (PTPRK) revisited: evolving insights into structure, function, and pathology. (PubMed, J Transl Med)

In this review, we elucidate the structural characteristics and functional roles of PTPRK in cellular signaling and disease pathogenesis. The variability of PTPRK suggests that the regulatory mechanisms governing its activity are intricate and worth further comprehensive investigation.

10 months ago

Review • Journal

EGFR (Epidermal growth factor receptor) • STAT3 (Signal Transducer And Activator Of Transcription 3) • CD4 (CD4 Molecule) • ADAM10 (ADAM Metallopeptidase Domain 10) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K)

10ms

Predictive Factors for Chemotherapy Response in Colorectal Liver Metastasis: A Retrospective Study Utilizing Next-Generation Sequencing. (PubMed, Ann Surg Oncol)

Gender, utilization of BTAs, and specific gene and pathway mutations may be significant predictors of chemotherapy response in CRLM patients. These findings highlight the role of genetic profiling in refining treatment strategies.

10 months ago

Retrospective data • Journal • Next-generation sequencing

KRAS (KRAS proto-oncogene GTPase) • KMT2A (Lysine Methyltransferase 2A) • EP300 (E1A binding protein p300) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K) • ACVR1B (Activin A Receptor Type 1B)

KRAS mutation • MLL mutation

1year

Role of Protein Tyrosine Phosphatases in Inflammatory Bowel Disease, Celiac Disease and Diabetes: Focus on the Intestinal Mucosa. (PubMed, Cells)

PTPs are now actively studied to develop new drugs. Also considering the availability of organoids as models to test new drugs in personalized ways, it is very likely that soon these proteins will be the targets of useful drugs.

1 year ago

Review • Journal

PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11) • PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2) • DUSP6 (Dual specificity phosphatase 6) • PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K)

1year

Integrative multi-omics profiling of colorectal cancer from a Hispanic/Latino cohort of patients. (PubMed, medRxiv)

Using integrative analysis, we also detected recurrent alterations in the WNT, TGFB, TP53, IGF2/PI3K, and RTK/RAS pathways. Our study thus advances the molecular profiling of CRC in Hispanics and Latinos; suggests precision medicine therapeutics can be tailored to an underrepresented community; and demonstrates genetic similarity can be an important component in understanding colorectal carcinogenesis.

1 year ago

Journal

ALK (Anaplastic lymphoma kinase) • TP53 (Tumor protein P53) • PIK3CA (Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha) • FGFR1 (Fibroblast growth factor receptor 1) • SMAD4 (SMAD family member 4) • IGF2 (Insulin-like growth factor 2) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K)

ALK fusion • PIK3CA amplification • SMAD4 mutation

over1year

PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity. (PubMed, Nat Commun)

Silencing PTPRK in liver cancer cell lines reduces colony-forming capacity and high-fat-fed PTPRK knockout mice exposed to a hepatic carcinogen develop smaller tumours. Our study defines the role of PTPRK in the regulation of hepatic glycolysis, lipid metabolism, and tumour development in obesity.

over 1 year ago

Journal

PPARG (Peroxisome Proliferator Activated Receptor Gamma) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K)

over1year

Exosomal circPTPRK promotes angiogenesis after radiofrequency ablation in hepatocellular carcinoma. (PubMed, Exp Biol Med (Maywood))

Mechanistic studies indicated that PLA2G4E is a downstream target of circPTPRK, and PLA2G4E overexpression reversed the inhibitory effect of circPTPRK knockdown on HUVEC angiogenesis. Our results indicated that exosomal circPTPRK activated HUVEC angiogenesis by upregulating PLA2G4E expression.

over 1 year ago

Journal

PTPRK (Protein Tyrosine Phosphatase Receptor Type K)

over1year

The receptor protein tyrosine phosphatase PTPRK promotes intestinal repair and catalysis-independent tumour suppression. (PubMed, J Cell Sci)

Contrary to the prevailing notion that PTPRK directly dephosphorylates EGFR, we find that PTPRK regulation of both EGFR and EMT is independent of its catalytic function. This suggests that additional adaptor and scaffold functions are important features of PTPRK signalling.

over 1 year ago

Journal

EGFR (Epidermal growth factor receptor) • PTPRK (Protein Tyrosine Phosphatase Receptor Type K)