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    BIOMARKER:

    PTPRF expression

    i
    Other names: PTPRF, Receptor-type tyrosine-protein phosphatase F, Leukocyte common antigen related, LAR, BNAH2
    Entrez ID:
    5792
    Related biomarkers:
    Expression
    almost2years
    High PPFIA1 Expression Could Promote Cancer Survival by Suppressing CD8+ T cells in Breast Cancer: drug discovery and machine learning approach (USCAP 2023)
    High PPFIA1 in patients with breast cancer is related to poor prognosis and decreased anticancer immune response, and erlotinib may enhance the therapeutic effect.
    PD(L)-1 Biomarker • IO biomarker • Machine learning
    |
    HER-2 (Human epidermal growth factor receptor 2) • PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PTPRF (Receptor-type tyrosine-protein phosphatase F) • PPFIA1 (PTPRF Interacting Protein Alpha 1)
    |
    PD-L1 expression • HER-2 negative • PTPRF expression
    |
    erlotinib
    2years
    FSCN1 induced PTPRF-dependent tumor microenvironment inflammatory reprogramming promotes lung adenocarcinoma progression via regulating macrophagic glycolysis. (PubMed, Cell Oncol (Dordr))
    This study investigated the reprogramming effects of FSCN1 and PTPRF on inflammatory cytokines in the LUAD microenvironment, revealing potential mechanisms by which FSCN1 and PTPRF promote tumor progression and providing a new experimental basis for LUAD treatment.
    Journal
    |
    IGF1 (Insulin-like growth factor 1) • CSF1 (Colony stimulating factor 1) • IL10 (Interleukin 10) • CCL2 (Chemokine (C-C motif) ligand 2) • PTPRF (Receptor-type tyrosine-protein phosphatase F) • IL4 (Interleukin 4)
    |
    PTPRF expression
    almost3years
    miR-647 inhibits hepatocellular carcinoma cell progression by targeting protein tyrosine phosphatase receptor type F. (PubMed, Bioengineered)
    In addition, the dual luciferase reporting identified PTPRF as a direct target of miR-647. We further demonstrated that miR-647 inhibitor or PTPRF knockdown administration boosted HCV-huh7.5 cell proliferation, migration, and invasion by targeting PTPRF.These findings provided clues for the mechanism of miR-647 in promoting the biology of HCV-huh7.5 cells by inhibiting the expression level of PTPRF.
    Journal
    |
    PTPRF (Receptor-type tyrosine-protein phosphatase F)
    |
    PTPRF expression
    4years
    PPARγ inhibits breast cancer progression by upregulating PTPRF expression. (PubMed, Eur Rev Med Pharmacol Sci)
    These results suggest that PPARγ inhibits tumor cell proliferation, at least in part, through direct regulation of the ptprf gene and that PPARγ is a potential target for breast cancer treatment.
    Journal
    |
    PTPRF (Receptor-type tyrosine-protein phosphatase F)
    |
    PTPRF expression
    |
    rosiglitazone