^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    PTH1R (Parathyroid Hormone 1 Receptor)

    i
    Other names: PTH1R, Parathyroid Hormone 1 Receptor, PTHR1, PTHR, Parathyroid Hormone/Parathyroid Hormone-Related Peptide Receptor, Parathyroid Hormone Receptor 1, PTH/PTHrP Type I Receptor, PTH/PTHr Receptor, PTH1 Receptor, Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor, Seven Transmembrane Helix Receptor, EKNS, PFE
    1year
    Single-cell transcriptomic analysis of glioblastoma reveals pericytes contributing to the blood-brain-tumor barrier and tumor progression. (PubMed, MedComm (2020))
    Evans Blue leakage and IgG detection in the brain tissue suggested a negative correlation between PTH1R expression levels and blood-brain barrier function. Further, a risk model based on differentially expressed genes in PTH1R+ pericytes had predictive value for GBM, as validated using independent and in-house cohorts.
    Journal
    |
    FN1 (Fibronectin 1) • PTH1R (Parathyroid Hormone 1 Receptor)
    almost3years
    Parathyroid hormone receptor (PTH1R) signaling mediates breast cancer metastasis to bone in mice. (PubMed, JCI Insight)
    Conversely, overexpression of PTHrP in 4T1 cells increased migration towards MC3T3-E1 osteoblasts and this was not inhibited by PTH. In conclusion, PTH1R expression is crucial in both osteoblasts and breast cancer cells for PTH to reduce bone metastases and in breast cancer cells this may be mediated in part by suppression of PTHrP.
    Preclinical • Journal
    |
    PTH1R (Parathyroid Hormone 1 Receptor) • PTHLH (Parathyroid Hormone Like Hormone)