^
    Contact us  to learn more about
    our Premium Content:  News alerts, weekly reports and conference planners
    GENE:

    PTGIS (Prostaglandin I2 Synthase)

    i
    Other names: PTGIS, Prostaglandin I2 Synthase, CYP8A1, Prostacyclin Synthase, PGIS, Cytochrome P450, Family 8, Subfamily A, Polypeptide 1, Prostaglandin I2 (Prostacyclin) Synthase, Hydroperoxy Icosatetraenoate Dehydratase, CYP8, PTGI
    Associations

    News

    Trials
    17d
    Adipocyte-driven STAT3-ANGPT2-PTGIS axis promotes cutaneous metastasis in breast cancer and represents a targetable pathway. (PubMed, NPJ Precis Oncol)
    Elevated STAT3, ANGPT2, and PTGIS levels correlated with reduced progression-free and disease-free survival. These findings highlight STAT3-mediated signaling and metabolic reprogramming as key drivers of CMBC progression and suggest a promising therapeutic target for this understudied and clinically challenging condition.
    Journal
    |
    STAT3 (Signal Transducer And Activator Of Transcription 3) • VEGFC (Vascular Endothelial Growth Factor C) • PTGIS (Prostaglandin I2 Synthase)
    over1year
    Generation of novel lipid metabolism-based signatures to predict prognosis and immunotherapy response for colorectal adenocarcinoma. (PubMed, Sci Rep)
    Notably, PIK3CG was expressed in B cells, while GGT5 and PTGIS were expressed in stromal cells. This study generates lipid metabolism-based signatures correlated with EMT, stemness and ICs for predicting prognosis of COAD, and provides potential therapeutic targets for immunotherapy in COAD.
    Journal • IO biomarker
    |
    PIK3CG (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Gamma) • PIK3CD (Phosphatidylinositol-4 5-Bisphosphate 3-Kinase Catalytic Subunit Delta) • PRKD1 (Protein Kinase D1) • TNFAIP8 (TNF Alpha Induced Protein 8) • TNFAIP8L2 (TNF Alpha Induced Protein 8 Like 2) • PTGIS (Prostaglandin I2 Synthase)
    over2years
    Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer. (PubMed, Aging (Albany NY))
    Furthermore, we validated the expression of PTGIS through qRT-PCR. In vitro and in vivo experiments also confirmed the effect of PTGIS on the malignant biological behavior of EC.
    Journal
    |
    ACACB (Acetyl-CoA Carboxylase Beta) • PTGIS (Prostaglandin I2 Synthase)
    over2years
    Validating the role of PTGIS gene in colorectal cancer by bioinformatics analysis and in vitro experiments. (PubMed, Sci Rep)
    Overexpression of PTGIS inhibited apoptosis and promoted proliferation, invasion, and migration ability of SW480 colorectal cancer cells. Analysis of the PTGIS gene in this study provides a theoretical basis for further exploring the pathogenesis of colorectal cancer and finding more accurate new targets for early screening and treatment of the cancer.
    Preclinical • Journal
    |
    PTGIS (Prostaglandin I2 Synthase)
    over2years
    Serum exosomal m6A demethylase FTO promotes gefitinib resistance in non-small cell lung cancer by up-regulating FLRT3, PTGIS and SIRPα expression. (PubMed, Pulm Pharmacol Ther)
    Furthermore, m6A sites were found in FLRT3, PTGIS, and SIRPA genes, and FTO was significantly positively correlated with the expression of these downstream genes. Overall, FTO m6A demethylase promotes gefitinib resistance in NSCLC patients by upregulating downstream FLRT3, PTGIS, and SIRPA expression, with these three downstream genes serving as strong prognostic indicators.
    Journal
    |
    FTO (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) • SIRPA (Signal Regulatory Protein Alpha) • PTGIS (Prostaglandin I2 Synthase)
    |
    gefitinib