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PTGER4 (Prostaglandin E Receptor 4)

News alerts, weekly reports and conference planners

12d

Immune microenvironment of Epstein-Barr virus (EBV)-negative compared to EBV-associated gastric cancers: implications for immunotherapy. (PubMed, J Immunother Cancer)

While certain markers of immunosuppression are found in the GC TiME regardless of EBV status, EBV(-) GCs, which are much more common than EBV+ GCs, overexpress components of the COX-2/PGE2 pathway. These findings provide novel insights into the immune microenvironments of EBV+ and EBV(-) GC, and offer potential targets to overcome resistance to anti-PD-(L)1 therapies.

12 days ago

Clinical • Journal • PD(L)-1 Biomarker • IO biomarker

CD8 (cluster of differentiation 8) • CXCR4 (Chemokine (C-X-C motif) receptor 4) • CD73 (5'-Nucleotidase Ecto) • PD-L2 (Programmed Cell Death 1 Ligand 2) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • CD163 (CD163 Molecule) • IDO1 (Indoleamine 2,3-dioxygenase 1) • CXCL9 (Chemokine (C-X-C motif) ligand 9) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • IL10 (Interleukin 10) • NT5E (5'-Nucleotidase Ecto) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • IL1A (Interleukin 1, alpha) • IL32 (Interleukin 32) • ITGAE (Integrin Subunit Alpha E) • ENTPD1 (Ectonucleoside Triphosphate Diphosphohydrolase 1) • IL1B (Interleukin 1, beta) • NOS2 (Nitric Oxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • PTGER4 (Prostaglandin E Receptor 4) • VSIR (V-Set Immunoregulatory Receptor)

ITGAE overexpression

30d

Lactobacillus fermentum MCC2760 Attenuates Heated Oil-Induced Brain Oxidative Stress and Inflammation via Modulation of NRF2 and NF-kB in Rats. (PubMed, Mol Nutr Food Res)

The present study is novel in demonstrating the protective role of probiotic LF against heated-oil-induced brain OS and inflammation in rats.

30 days ago

Preclinical • Journal

IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • ICAM1 (Intercellular adhesion molecule 1) • CCL2 (Chemokine (C-C motif) ligand 2) • IL1B (Interleukin 1, beta) • PTGER4 (Prostaglandin E Receptor 4)

Application of a risk score model based on glycosylation-related genes in the prognosis and treatment of patients with low-grade glioma. (PubMed, Front Immunol)

The risk score characteristics can thus guide clinical medication decisions for LGG patients. Our study established glycosylation-related gene risk score signatures, providing new perspectives and approaches for prognostic prediction and treatment of LGG.

1 month ago

Journal

CHI3L1 (Chitinase 3-like 1) • PTGER4 (Prostaglandin E Receptor 4) • TNFRSF12A (TNF Receptor Superfamily Member 12A)

2ms

Pivotal roles for cancer cell-intrinsic mPGES-1 and autocrine EP4 signaling in suppressing anti-tumor immunity. (PubMed, JCI Insight)

In hosts treated with an adenosine deaminase inhibitor, Ptger4 KO tumor cells accumulated adenosine and gave rise to tumors. These studies reveal an unexpected finding - a non-redundant role for the autocrine mPGES1-PGE2-EP4 signaling axis in pancreatic cancer cells - further nominating mPGES-1 inhibition and EP4 blockade as immune-sensitizing therapy in cancer.

2 months ago

Journal

KRAS (KRAS proto-oncogene GTPase) • TNFA (Tumor Necrosis Factor-Alpha) • PTGER4 (Prostaglandin E Receptor 4) • PTGES (Prostaglandin E Synthase)

KRAS G12D • KRAS G12

4ms

Combined detection of SHOX2 and PTGER4 methylation with serum marker CYFRA21-1 for improved diagnosis of malignant pleural mesothelioma. (PubMed, J Clin Pathol)

The combined detection of SHOX2 and PTGER4 methylation alongside serum CYFRA21-1 level significantly enhances the diagnosis of MPM. Additionally, CYFRA21-1 can serve as a prognostic indicator for MPM.

4 months ago

Journal

PTGER4 (Prostaglandin E Receptor 4) • SEPTIN9 (Septin 9) • SHOX2 (SHOX Homeobox 2)

6ms

Molecular Aspects of Piperine in Signaling Pathways Associated with Inflammation in Head and Neck Cancer. (PubMed, Int J Mol Sci)

Piperine also reduced the expression of inflammatory molecules (PTGS2 and PTGER4), regulated the secretion of cytokines (IFN-γ and IL-8) and modulated the expression of ERK and p38. These results suggest that piperine exerts anticancer effects on tumor cells by regulating signaling pathways associated with head and neck cancer.

6 months ago

Journal

IFNG (Interferon, gamma) • CXCL8 (Chemokine (C-X-C motif) ligand 8) • MMP2 (Matrix metallopeptidase 2) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • MMP9 (Matrix metallopeptidase 9) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • PTGER4 (Prostaglandin E Receptor 4)

6ms

Two genome-wide interaction loci modify the association of nonsteroidal anti-inflammatory drugs with colorectal cancer. (PubMed, Sci Adv)

After adjusting for multiple comparisons, we identified statistically significant interactions between regular aspirin/NSAID use and variants in 6q24.1 (top hit rs72833769), which has evidence of influencing expression of TBC1D7 (a subunit of the TSC1-TSC2 complex, a key regulator of MTOR activity), and variants in 5p13.1 (top hit rs350047), which is associated with expression of PTGER4 (codes a cell surface receptor directly involved in the mode of action of aspirin). Genetic variants with functional impact may modulate the chemopreventive effect of regular aspirin use, and our study identifies putative previously unidentified targets for additional mechanistic interrogation.

6 months ago

Journal

TSC2 (TSC complex subunit 2) • TSC1 (TSC complex subunit 1) • PTGER4 (Prostaglandin E Receptor 4)

aspirin

8ms

Cellular senescence and metabolic reprogramming model based on bulk/single-cell RNA sequencing reveals PTGER4 as a therapeutic target for ccRCC. (PubMed, BMC Cancer)

We also demonstrated that PTGER4, a key gene in SeMRM, regulated ccRCC cell proliferation, lipid levels and the cell cycle in vivo and in vitro. Together, the utilization of SeMRM has the potential to function as a dependable clinical characteristic to increase the accuracy of prognostic assessment for patients diagnosed with ccRCC, thereby facilitating the selection of suitable treatment strategies.

8 months ago

Journal

PTGER4 (Prostaglandin E Receptor 4)

9ms

Distinct fibroblast subpopulations associated with bone, brain or intrapulmonary metastasis in advanced non-small-cell lung cancer. (PubMed, Clin Transl Med)

This study unveils the direct interplay between tumour cells and CAFs in NSCLC with bone or brain metastasis and identifies potential therapeutic targets for inhibiting metastasis by disrupting these critical cell-cell interactions.

9 months ago

Journal • Metastases

HGF (Hepatocyte growth factor) • SPP1 (Secreted Phosphoprotein 1) • PTGER4 (Prostaglandin E Receptor 4)

9ms

Comparing anti-tumor and anti-self immunity in a patient with melanoma receiving immune checkpoint blockade. (PubMed, J Transl Med)

This comprehensive study of a single patient with melanoma experiencing both tumor regression and irAEs on ICB explores the immune landscape across these tissues, revealing similarities between anti-tumor and anti-self immunity. Further, it highlights expression of the COX-2/PGE2 pathway, which is known to be immunosuppressive and potentially mediates ICB resistance. Ongoing clinical trials of COX-2/PGE2 pathway inhibitors targeting the major COX-2 inducer IL-1B, COX-2 itself, or the PGE2 receptors EP2 and EP4 present new opportunities to promote anti-tumor activity, but may also have the potential to enhance the severity of ICB-induced irAEs.

9 months ago

Journal • Checkpoint inhibition • Checkpoint block

PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • CSF1R (Colony stimulating factor 1 receptor) • SOCS1 (Suppressor Of Cytokine Signaling 1) • TGFB1 (Transforming Growth Factor Beta 1) • FOXP3 (Forkhead Box P3) • IL1B (Interleukin 1, beta) • KLRG1 (Killer Cell Lectin Like Receptor G1) • PTGER4 (Prostaglandin E Receptor 4)

9ms

Exploring miRNA‑target gene profiles associated with drug resistance in patients with breast cancer receiving neoadjuvant chemotherapy. (PubMed, Oncol Lett)

Networks between DEMs and DEGs were highly correlated with mitosis, metabolism, drug transport, and immune responses. Consequently, these targets could be used as predictive markers and therapeutic targets for clinical applications to enhance treatment outcomes for patients with BC.

9 months ago

Journal

ETS1 (ETS Proto-Oncogene 1) • MIR1246 (MicroRNA 1246) • MIR484 (MicroRNA 484) • BAK1 (BCL2 Antagonist/Killer 1) • PTGER4 (Prostaglandin E Receptor 4)

10ms

The signature of cancer methylation markers in maternal plasma: Factors influencing the development and application of cancer liquid biopsy assay. (PubMed, Gene)

Our study shows that cancer and fetus/placenta exhibit similar DNA methylation patterns, and some gastrointestinal cancer and lung cancer-related methylation markers also show positives in maternal plasma. This is an important consideration in the design and application of plasma-based cancer liquid biopsy assays.

10 months ago

Journal • Liquid biopsy • Biopsy

CLIP4 (CAP-Gly Domain Containing Linker Protein Family Member 4) • RASSF1 (Ras Association Domain Family Member 1) • PTGER4 (Prostaglandin E Receptor 4) • SDC2 (Syndecan 2) • SEPTIN9 (Septin 9) • SHOX2 (SHOX Homeobox 2)

11ms

Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors. (PubMed, Cell Rep Med)

Analysis of such a gene signature uncovers a specific transcriptional program associated with mPMN-MDSC differentiation and allows us to identify that, in patients with either solid or hematologic tumors and in GDs, CD52, CD84, and prostaglandin E receptor 2 (PTGER2) represent potential mPMN-MDSC-associated markers. Altogether, our findings indicate that mature PMN-MDSCs distinctively undergo specific reprogramming during differentiation and lay the groundwork for selective immunomonitoring, and eventually targeting, of mature PMN-MDSCs.

11 months ago

Journal

CD52 (CD52 Molecule) • CEACAM8 (CEA Cell Adhesion Molecule 8) • PTGER2 (Prostaglandin E Receptor 2) • PTGER4 (Prostaglandin E Receptor 4)

12ms

Blockade of EP4 by ASP7657 Modulates Myeloid Cell Differentiation In Vivo and Enhances the Antitumor Effect of Radiotherapy. (PubMed, Biomed Res Int)

Notably, ASP7657 also significantly enhanced the antitumor efficacy of radiotherapy in an anti-PD-1 antibody refractory model. These results indicate that the therapeutic potential of ASP7657 arises via upregulation of DCs and subsequent CD8 T cell activation in addition to suppression of MDSCs in mouse models and that combining EP4 antagonists with radiotherapy or an anti-PD-1 antibody can improve antitumor efficacy.

12 months ago

Preclinical • Journal

CD8 (cluster of differentiation 8) • PTGER4 (Prostaglandin E Receptor 4)

1year

Intercellular Molecular Crosstalk Networks within Invasive and Immunosuppressive Tumor Microenvironment Subtypes Associated with Clinical Outcomes in Four Cancer Types. (PubMed, Biomedicines)

The spatial co-location information of cellular and molecular interactions was further verified by spatial transcriptome data from colorectal cancer clinical samples. Overall, our study revealed the heterogeneity within the TME, highlighting the potential pro-invasion and pro-immunosuppressive functions and cellular infiltration characteristics of specific subTMEs, and also identified the key cellular and molecular interactions that might be associated with the survival, invasion, immune escape, and classification of cancer patients across four cancer types.

1 year ago

Clinical data • Journal • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • SPP1 (Secreted Phosphoprotein 1) • SDC1 (Syndecan 1) • TGFB1 (Transforming Growth Factor Beta 1) • COL1A1 (Collagen Type I Alpha 1 Chain) • COL6A3 (Collagen Type VI Alpha 3 Chain) • COL4A1 (Collagen Type IV Alpha 1 Chain) • COL6A2 (Collagen Type VI Alpha 2 Chain) • ITGA2 (Integrin Subunit Alpha 2) • LGALS9 (Galectin 9) • PTGER4 (Prostaglandin E Receptor 4)

1year

A novel multimodal prediction model based on DNA methylation biomarkers and low-dose computed tomography images for identifying early-stage lung cancer. (PubMed, Chin J Cancer Res)

The present multimodal prediction model could more efficiently distinguish early-stage lung cancer from benign PNs. A prognostic index based on DNA methylation and lung cancer driver gene alterations may separate the patients into groups with good or poor prognosis.

1 year ago

Journal • Epigenetic controller

TP53 (Tumor protein P53) • PTGER4 (Prostaglandin E Receptor 4) • SHOX2 (SHOX Homeobox 2)

TP53 mutation

1year

SYNGN: A novel epigenetic platform for patient-specific drug-matching in glioblastoma. (SNO 2023)

Most recently we have added assessment of chromatin remodelling (H3K4me3, H3K27ac, H3K3me3, H3K27me3 and ATACSeq) to the pipeline and shown that redistribution of selected histone marks as well as shifts in chromatin states across the genome identifies known and novel druggable regulatory mechanisms in GSC, which are specific of the neoplastic context. In conclusion, SYNGN is an epigenetic platform which can identify patient-specific druggable targets in glioblastoma.

1 year ago

Clinical

NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • PTGER4 (Prostaglandin E Receptor 4)

IDH wild-type

1year

SYNGN: A novel epigenetic platform for patient-specific drug-matching in glioblastoma. (SNO 2023)

1 year ago

Clinical

NTRK2 (Neurotrophic tyrosine kinase, receptor, type 2) • PTGER4 (Prostaglandin E Receptor 4)

IDH wild-type

1year

N6-methyladenosine Methyltransferase METTL3 Enhances PTGER2 Expression to Increase Ovarian Cancer Stemness and Chemoresistance. (PubMed, Front Biosci (Landmark Ed))

Our work defines PTGER2 as an oncogene and reveals that PTGER2 is a prognostic predictor and novel therapeutic target for the management of ovarian cancer.

1 year ago

Journal

METTL3 (Methyltransferase Like 3) • PTGER2 (Prostaglandin E Receptor 2) • PTGER4 (Prostaglandin E Receptor 4)

carboplatin

1year

A single-cell landscape of pre- and post-menopausal high-grade serous ovarian cancer ascites. (PubMed, iScience)

GO analysis revealed the pre-menopausal tumor microenvironments (TME) are closely associated with viral infection, while the post-menopausal TME are mostly related to the IL-17 immune pathway. SPP1/CD44-mediated crosstalk between myeloid cells and B cells, NK cells, and stromal cells mainly present in the pre-menopausal group, while SPP1/PTGER4 -mediated crosstalk between myeloid cells and epithelial cells mostly present in the post-menopausal group.

1 year ago

Journal

SPP1 (Secreted Phosphoprotein 1) • IL17A (Interleukin 17A) • PTGER4 (Prostaglandin E Receptor 4)

1year

Association of PTGER4 and PRKAA1 genetic polymorphisms with gastric cancer. (PubMed, BMC Med Genomics)

This study suggests that PTGER4 and PRKAA1 SNPs might affect the susceptibility of GC, providing a new biological perspective for GC risk assessment, pathogenesis exploration, and personalized treatment.

1 year ago

Journal

RHOA (Ras homolog family member A) • AMPK (Protein Kinase AMP-Activated Catalytic Subunit Alpha 1) • PTGER4 (Prostaglandin E Receptor 4)

over1year

In vitro cross-talk between metastasis-competent circulating tumor cells and platelets in colon cancer: a malicious association during the harsh journey in the blood. (PubMed, Front Cell Dev Biol)

Incubation with CTC conditioned medium led to platelet aggregation and activation, supporting the hypothesis that their interaction may contribute to preserve CTC integrity during their journey in the bloodstream. Moreover, co-culture with platelets influenced the expression of several genes involved in invasiveness and EMT maintenance in CTCs.

over 1 year ago

Preclinical • Journal • Circulating tumor cells • Tumor cell

PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • VEGFB (Vascular Endothelial Growth Factor B) • SNAI2 (Snail Family Transcriptional Repressor 2) • IL33 (Interleukin 33) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • PTGER2 (Prostaglandin E Receptor 2) • PTGER4 (Prostaglandin E Receptor 4)

over1year

Transcriptomics-based analysis of sex-differentiated mechanisms of hepatotoxicity in zebrafish after long-term exposure to bisphenol AF. (PubMed, Ecotoxicol Environ Saf)

Furthermore, BPAF exposure altered hepatic histological structure and inhibited antioxidant capability in both male and female livers. Overall, this study revealed different regulation networks involved in the sex-dependent effects of BPAF on the fish liver, and these detected DEGs upon BPAF exposure might be used as potential biomarkers for further assessing sex-specific hepatotoxicity following environmental EDC exposure.

over 1 year ago

Journal

IFNG (Interferon, gamma) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • YAP1 (Yes associated protein 1) • IGF1 (Insulin-like growth factor 1) • IFNA1 (Interferon Alpha 1) • PTGER2 (Prostaglandin E Receptor 2) • PTGER4 (Prostaglandin E Receptor 4)

HIF1A expression

over1year

Cell-Free Methylated PTGER4 and SHOX2 Plasma DNA as a Biomarker for Therapy Monitoring and Prognosis in Advanced Stage NSCLC Patients. (PubMed, Diagnostics (Basel))

In contrast, the combination of the methylation values for both genes shows a clear difference between responders vs. non-responders at the time of re-staging. Furthermore, blood drawing into tubes stabilizing the sample allows researchers more flexibility.

over 1 year ago

Journal • Metastases

PTGER4 (Prostaglandin E Receptor 4) • SHOX2 (SHOX Homeobox 2)

over1year

In Vivo Staging the Progression of Colitis and Associated Cancer by Concurrent Microimaging of Key Biomarkers. (PubMed, Anal Chem)

In vivo CLE imaging exhibited the correlation of severe colonic crypt structural alteration with a higher biomarker expression in adenoma and carcinoma stages. This strategy shows promise in benefiting patients undergoing CRC progression with in-time, noninvasive, and precise pathological staging, thus providing valuable guidance for selecting therapeutic strategies.

over 1 year ago

Preclinical • Journal

KDR (Kinase insert domain receptor) • VEGFA (Vascular endothelial growth factor A) • PTGER4 (Prostaglandin E Receptor 4)

KDR expression

over1year

TFF3 promotes clonogenic survival of colorectal cancer cells through upregulation of EP4 via activation of STAT3. (PubMed, Transl Cancer Res)

Activated STAT3 bound to PTGER4 promoter, the gene encoding for EP4, and facilitated PTGER4 transcription. TFF3 promotes clonogenic survival of CRC cells via upregulating EP4 expression.

over 1 year ago

Journal

STAT3 (Signal Transducer And Activator Of Transcription 3) • TFF3 (Trefoil factor 3) • PTGER4 (Prostaglandin E Receptor 4)

TFF3 expression

over1year

A novel angiogenesis-related scoring model predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma. (PubMed, Clin Exp Med)

DLBCL patients in high-score group were resistant to doxorubicin and cisplatin, which are components of frequently used chemotherapy regimens, but more sensitive to gemcitabine and temozolomide. Using RT-qPCR, we found that two candidate risk genes, RAPGEF2 and PTGER2, were over-expressed in DLBCL tissues compared with control tissues. Taken together, the ARG-based scoring model provides a promising direction for the prognosis and immune status of DLBCL patients, and benefits the development of personalized treatment for DLBCL patients.

over 1 year ago

Journal

PTGER2 (Prostaglandin E Receptor 2) • PTGER4 (Prostaglandin E Receptor 4)

cisplatin • gemcitabine • temozolomide • doxorubicin hydrochloride

over1year

Dissecting the genetic heterogeneity of gastric cancer. (PubMed, EBioMedicine)

Our findings show that the pathophysiology of GC is genetically heterogenous according to location and histopathology. Moreover, our findings point to common molecular mechanisms underlying cardia GC and OAC/BO.

over 1 year ago

Journal

MUC1 (Mucin 1) • PSCA (Prostate Stem Cell Antigen 2) • PTGER4 (Prostaglandin E Receptor 4)

MUC1 expression

over1year

A senescence-based prognostic gene signature for colorectal cancer and identification of the role of SPP1-positive macrophages in tumor senescence. (PubMed, Front Immunol)

Our study presents a novel model based on senescence-related genes that can identify CRC patients with a poor prognosis and an immunosuppressive tumor microenvironment. SPP1 macrophages may correlate with cell senescence leading to poor prognosis.

over 1 year ago

Journal • Gene Signature • IO biomarker

DKK1 (dickkopf WNT signaling pathway inhibitor 1) • SPP1 (Secreted Phosphoprotein 1) • FGF2 (Fibroblast Growth Factor 2) • CD68 (CD68 Molecule) • CDKN1A (Cyclin-dependent kinase inhibitor 1A) • IGFBP3 (Insulin-like growth factor binding protein 3) • PTGER2 (Prostaglandin E Receptor 2) • PTGER4 (Prostaglandin E Receptor 4)

over1year

Accurate detection of early-stage lung cancer using a panel of circulating cell-free DNA methylation biomarkers. (PubMed, Biomark Res)

The 7 novel DMRs could be promising methylation biomarkers that merits further development as a noninvasive test for early detection of lung cancer.

over 1 year ago

Journal • Epigenetic controller

HOXD8 (Homeobox D8) • ITGA4 (Integrin, alpha 4) • HOXB4 (Homeobox B4) • PTGER4 (Prostaglandin E Receptor 4)

over1year

Investigation into the immune microenvironment of gastroenteropancreatic high-grade neuroendocrine carcinoma. (ASCO 2023)

This pilot study identified trends in gene expression associated with clinical outcomes. While statistical significance was precluded by limited sample size, our results suggest trends toward increased TME immune cell infiltration in age 6 month OS. Rational drug development for affected patients should target these specific abnormalities.

over 1 year ago

PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • ER (Estrogen receptor) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • PTPRC (Protein Tyrosine Phosphatase Receptor Type C) • STING (stimulator of interferon response cGAMP interactor 1) • ICAM1 (Intercellular adhesion molecule 1) • TWIST1 (Twist Family BHLH Transcription Factor 1) • IFI16 (Interferon Gamma Inducible Protein 16) • CX3CR1 (C-X3-C Motif Chemokine Receptor 1) • HNF1A (HNF1 Homeobox A) • MMP7 (Matrix metallopeptidase 7) • NKG2D (killer cell lectin like receptor K1) • PTGER4 (Prostaglandin E Receptor 4)

nCounter® PanCancer IO 360™ Panel

almost2years

Exploration of the damage and mechanisms of BPS exposure on the uterus and ovary of adult female mice. (PubMed, Sci Total Environ)

Further pan cancer and ovarian cancer survival analysis based on human diseases database pointed out, Foxa1, Gata3, S100a8 and Shh for uterus, Itgam, Dhcr7, Fdps, Hmgcr, Hsd11b1, Hsd3b1, Ptges, F3, Fn1, Ptger4 and Srd5a1 for ovary were significant correlation with cancer. The findings suggest that BPS causes some histopathological changes, alters the expressions of hub genes, enhances uterine and ovarian tumors or even cancer risks.

almost 2 years ago

Preclinical • Journal

S100A8 (S100 Calcium Binding Protein A8) • FOXA1 (Forkhead Box A1) • ITGAM (Integrin, alpha M) • GATA3 (GATA binding protein 3) • HSD3B1 (Hydroxy-Delta-5-Steroid Dehydrogenase 3 Beta- And Steroid Delta-Isomerase 1) • DHCR7 (7-Dehydrocholesterol Reductase) • PTGER4 (Prostaglandin E Receptor 4) • SRD5A1 (Steroid 5 Alpha-Reductase 1)

almost2years

Angioimmunoblastic T-cell Lymphoma: High CD8+Tumour-Infiltrating Lymphocytes Indicated Exhaustion and Poor Prognosis (USCAP 2023)

Our research demonstrates that the exhaustion status of CD8 + TILs in AITL was characterized by the high expression level of multiple IC. The more CD8 + TILs, the more proportion of exhausted CD8 + TILs, which may be one of the main reasons for the poor prognosis of patients with high CTL and high CD8 + TILs (Fig 2). Our study could not only help to predict survival risks of AITL patients, but also was valuable in guiding immunotherapy strategies

almost 2 years ago

Tumor-infiltrating lymphocyte • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • PD-1 (Programmed cell death 1) • LAG3 (Lymphocyte Activating 3) • CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • TIGIT (T Cell Immunoreceptor With Ig And ITIM Domains 2) • GZMB (Granzyme B) • GZMA (Granzyme A) • PRF1 (Perforin 1) • PTGER4 (Prostaglandin E Receptor 4)

PD-1 expression • LAG3 expression • HAVCR2 expression • CD8-H • CTLA4 expression

almost2years

Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer. (PubMed, Nat Commun)

We further validate the top ligand-receptor interaction pairs (i.e., LGALS9-SLC1A5 and SPP1-PTGER4 between tumor cells and macrophages) associated with unique transcriptome in additional 542 HCC patients. Our study unveils stable molecular networks of malignant ecosystems, which may open a path for therapeutic exploration.

almost 2 years ago

Journal

SPP1 (Secreted Phosphoprotein 1) • SLC1A5 (Solute Carrier Family 1 Member 5) • LGALS9 (Galectin 9) • PTGER4 (Prostaglandin E Receptor 4)

2years

miR-3614-5p downregulation promotes cadmium-induced breast cancer cell proliferation and metastasis by targeting TXNRD1. (PubMed, Ecotoxicol Environ Saf)

Importantly, luciferase reporter assays further verified that miR-3614-5p suppressed the expression of TXNRD1 by directly binding to the 3'-untranslated region (UTR), and TXNRD1 inhibition significantly repressed the proliferation and metastasis capacity of BC cells upon Cd exposure. Together, our findings demonstrated that Cd exposure repressed the expression of miR-3614-5p, thus activating TXNRD1 expression, which promoted the abnormal proliferation and metastasis of BC cells.

2 years ago

Journal

ALDH1A3 (Aldehyde Dehydrogenase 1 Family Member A3) • PTGER4 (Prostaglandin E Receptor 4) • RASGRF2 (Ras Protein Specific Guanine Nucleotide Releasing Factor 2) • TRIM38 (Tripartite Motif Containing 38)

miR-361 expression

2years

Significance of Hypermethylation of Tumor-Suppressor Genes PTGER4 and ZNF43 at CpG Sites in the Prognosis of Colorectal Cancer. (PubMed, Int J Mol Sci)

Aberrant methylation at specific CpG sites indicates tissue with aggressive behavior. Therefore, the differential methylation of PTGER4 and ZNF43 at specific loci can be employed for the prognosis of patients with CRC.

2 years ago

Journal

PTGER4 (Prostaglandin E Receptor 4)

2years

First-in-human study of ONO-4578, an antagonist of prostaglandin E receptor 4, alone and with nivolumab in solid tumors. (PubMed, Cancer Sci)

Considering safety, efficacy, and pharmacokinetics/pharmacodynamics results, ONO-4578 40 mg daily with nivolumab 240 mg biweekly was selected as the recommended dose for future clinical trials. (Registration: JapicCTI-173496 and NCT03155061).

2 years ago

P1 data • Journal

PTGER4 (Prostaglandin E Receptor 4)

Opdivo (nivolumab) • BMS-986310

over2years

Polymorphisms of COX/PEG2 pathway-related genes are associated with the risk of lung cancer: A case-control study in China. (PubMed, Int Immunopharmacol)

These results contribute to a better understanding of the pathogenesis of lung cancer and provide new clues for the early detection and personalized treatment of the disease.

over 2 years ago

Journal

PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) • PTGER4 (Prostaglandin E Receptor 4)

over2years

Identification and Development of Inflammatory Response-Related Genes Signature Associated With Prognosis Evaluation and Immune Status of Bladder Cancer. (PubMed, Front Cell Dev Biol)

The study defined a new prognostic signature consisting of seven IRGs, which could effectively predict the prognosis of patients with BLCA and reveal relationship of immune features in BLCA with different risk scores. The study also provided a possible indicator for targeted therapy.

over 2 years ago

Journal • IO biomarker

ROS1 (Proto-Oncogene Tyrosine-Protein Kinase ROS) • RIPK2 (Receptor Interacting Serine/Threonine Kinase 2) • MMP14 (Matrix Metallopeptidase 14) • PTGER4 (Prostaglandin E Receptor 4)

almost3years

Effect of Piper cubeba total extract and isolated lignans on head and neck cancer cell lines and normal fibroblasts. (PubMed, J Pharmacol Sci)

The results showed that the P. cubeba extract and different lignans do not alter the cellular morphology, but decrease cell proliferation and migration, have low cytotoxic and genotoxic effects, probably due to the alteration of the expression of genes and proteins involved with inflammatory process. From these data, we can conclude that the lignans cubebin and methylcubebin had a greater effect on head and neck cancer cells in the antiproliferative, antimigratory and genotoxic action, and could be the target of the development of new therapies including possible new drugs as a therapeutic resource for the treatment of head and neck cancer due to its immense range of biological properties.

almost 3 years ago

Preclinical • Journal

MMP2 (Matrix metallopeptidase 2) • PTGS2 (Prostaglandin-Endoperoxide Synthase 2) • MMP9 (Matrix metallopeptidase 9) • PTGER4 (Prostaglandin E Receptor 4)

PTGS2 expression

almost3years

Eicosanoid regulation of debris-stimulated metastasis. (PubMed, Proc Natl Acad Sci U S A)

Pharmacological abrogation of both sEH and EP4 eicosanoid pathways prevents hepato-pancreatic tumor growth and liver metastasis by promoting macrophage phagocytosis of debris and counterregulating a protumorigenic eicosanoid and cytokine storm. Therefore, stimulating the clearance of tumor cell debris via combined sEH and EP4 inhibition is an approach to prevent debris-stimulated metastasis and tumor growth.

almost 3 years ago

Journal

PTGER4 (Prostaglandin E Receptor 4)

almost3years

Angioimmunoblastic T-cell Lymphoma: The Significance of HAVCR2/TIM3 in CD8+ Tumour Infiltrating Lymphocytes (USCAP 2022)

Our research demonstrates that HAVCR2/TIM3 was closely related to CD8+TILs both in protein and gene level, and exhibited an inferior OS in AITL. The function of HAVCR2/TIM3 could be regulated by some transcriptional genes, and the synergistic action of HAVCR2/TIM3 and other inhibitory receptors might lead to CD8+TILs exhaustion in AITL and result in poor prognosis, which indicate HAVCR2/TIM3 could be a novel target in AITL therapy and deserve further research.

almost 3 years ago

Tumor-Infiltrating Lymphocyte • IO biomarker

CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • LAG3 (Lymphocyte Activating 3) • HAVCR2 (Hepatitis A Virus Cellular Receptor 2) • GZMB (Granzyme B) • GZMA (Granzyme A) • PRF1 (Perforin 1) • PTGER4 (Prostaglandin E Receptor 4)

HAVCR2 expression • CD8-H