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    BIOMARKER:

    PTBP1 underexpression

    i
    Other names: PTBP1, Polypyrimidine Tract Binding Protein 1, Heterogeneous Nuclear Ribonucleoprotein I, Polypyrimidine Tract Binding Protein (Heterogeneous Nuclear Ribonucleoprotein I), Polypyrimidine Tract-Binding Protein 1, 57 KDa RNA-Binding Protein PPTB-1, HnRNP I, PTB, Heterogeneous Nuclear Ribonucleoprotein Polypeptide I, RNA-Binding Protein, HNRNP-I, HNRNPI, HNRPI, PTB-1, PTB-T, PTB2, PTB3, PTB4, PPTB
    Entrez ID:
    5725
    Related biomarkers:
    Expression
    2years
    Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis. (PubMed, Cell Mol Biol (Noisy-le-grand))
    The mRNA level and protein expression level of CDC25a in YBX1/HNRNPK/A549 were both significantly higher than those in YBX1/A549 cell line and HNRNPK/A549 (P<0.001). All the above results indicated that the interaction between YBX1 and HNRNP regulated the expression of CDC25a, and further got involved in LC metastasis.
    Journal
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    PTBP1 (Polypyrimidine Tract Binding Protein 1) • YBX1 (Y-Box Binding Protein 1) • HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K) • RASGRF1 (Ras Protein Specific Guanine Nucleotide Releasing Factor 1) • CDC25A (Cell Division Cycle 25A) • GNRP (Ras-Specific Guanine Nucleotide-Releasing Factor 1)
    |
    PTBP1 underexpression
    over2years
    KITENIN promotes aerobic glycolysis through PKM2 induction by upregulating the c-Myc/hnRNPs axis in colorectal cancer. (PubMed, Cell Biosci)
    The oncoprotein KITENIN induces PKM2-mediated aerobic glycolysis by upregulating the c-Myc/hnRNPs axis.
    Journal
    |
    MYC (V-myc avian myelocytomatosis viral oncogene homolog) • LDHA (Lactate dehydrogenase A) • CCND1 (Cyclin D1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • HIF1A (Hypoxia inducible factor 1, alpha subunit) • PTBP1 (Polypyrimidine Tract Binding Protein 1) • PKM (Pyruvate Kinase M1/2) • SLC2A1 (Solute Carrier Family 2 Member 1)
    |
    CCND1 expression • HIF1A expression • PTBP1 underexpression
    almost4years
    Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization. (PubMed, Cancer Med)
    These results suggested that hnRNP G-T promotes the cell growth of CRC by regulating the mRNA of ZDHHC11. Therefore, hnRNP G-T will be highlighted as an effective therapeutic target with less adverse effects in CRC therapy.
    Journal
    |
    PTBP1 (Polypyrimidine Tract Binding Protein 1)
    |
    PTBP1 underexpression
    4years
    Comment on 'Long noncoding RNA UCA1 promotes glutamine-driven anaplerosis of bladder cancer by interacting with hnRNP I/L to upregulate GPT2 expression' by Chen et al.'". (PubMed, Transl Oncol)
    Inhibition of either UCA1, hnRNPI/L, or GPT2 significantly reduces bladder cancer tumor growth in the mice model. This work explores a new mechanism for glutamine metabolism and the novel therapeutic target of the UCA1-hnRNPI/L-GPT2 axis across malignancies.
    Journal
    |
    PTBP1 (Polypyrimidine Tract Binding Protein 1)
    |
    PTBP1 underexpression
    4years
    Long noncoding RNA UCA1 promotes glutamine-driven anaplerosis of bladder cancer by interacting with hnRNP I/L to upregulate GPT2 expression. (PubMed, Transl Oncol)
    We also systematically confirmed the influence of UCA1 and hnRNP I/L on metabolism and proliferation via glutamine-driven anaplerosis in BLCA. Our study revealed the critical role of UCA1-mediated mechanisms involved in glutamine-driven anaplerosis and provided novel evidence that lncRNA regulates metabolic reprogramming in tumor cells.
    Journal
    |
    PTBP1 (Polypyrimidine Tract Binding Protein 1)
    |
    PTBP1 underexpression