News - PTBP1 overexpression

almost2years

RNA Binding Protein PTBP1 Promotes the Metastasis of Gastric Cancer by Stabilizing PGK1 mRNA. (PubMed, Cells)

Furthermore, the PGK1/SNAIL axis could be required for PTBP1's function in the promotion of GC cell migration. These discoveries suggest that PTBP1 could be a promising therapeutic target for GC.

almost 2 years ago

Journal

PTBP1 (Polypyrimidine Tract Binding Protein 1) • PGK1 (Phosphoglycerate Kinase 1)

PTBP1 overexpression

almost2years

USP46 enhances tamoxifen resistance in breast cancer cells by stabilizing PTBP1 to facilitate glycolysis. (PubMed, Biochim Biophys Acta Mol Basis Dis)

In conclusion, this study highlights the critical role of the USP46/PTBP1/PKM2 axis in TAM resistance in BC. Targeted therapy against USP46 may represent a promising strategy to improve the prognosis of TAM-resistant patients.

almost 2 years ago

Journal

ER (Estrogen receptor) • PTBP1 (Polypyrimidine Tract Binding Protein 1) • USP46 (Ubiquitin Specific Peptidase 46)

PTBP1 overexpression

tamoxifen

over2years

CircYIPF6 regulates glioma cell proliferation, apoptosis, and glycolysis through targeting miR-760 to modulate PTBP1 expression. (PubMed, Transl Neurosci)

Furthermore, circYIPF6 knocking down effectively impeded glioma growth in vivo. These findings suggested that circYIPF6 participated in the proliferation, apoptosis, and glycolysis of glioma through the miR-760/PTBP1 axis.

over 2 years ago

Journal • IO biomarker

BCL2 (B-cell CLL/lymphoma 2) • LDHA (Lactate dehydrogenase A) • BAX (BCL2-associated X protein) • PTBP1 (Polypyrimidine Tract Binding Protein 1) • MIR760 (MicroRNA 760) • SLC2A1 (Solute Carrier Family 2 Member 1)

PTBP1 overexpression

almost3years

A pan-cancer analysis of the oncogenic role of polypyrimidine tract binding protein 1 (PTBP1) in human tumors. (PubMed, Medicine (Baltimore))

These results provide clues to better understand PTBP1 from the perspective of bioinformatics and highlight its importance in various human cancers.

almost 3 years ago

Journal • Pan tumor

PTBP1 (Polypyrimidine Tract Binding Protein 1)

PTBP1 overexpression

over3years

Clinicopathological significance and prognostic value of polypyrimidine tract binding protein 1 (PTBP1) in gastric cancer. (PubMed, Transl Cancer Res)

PTBP1 is up-regulated and predicts poor prognosis in gastric cancer. PTBP1 may serve as a biomarker of poor prognosis and a novel target in treating gastric cancer.

over 3 years ago

Journal

PTBP1 (Polypyrimidine Tract Binding Protein 1)

PTBP1 overexpression

over3years

HOXA11-AS1 Promotes PD-L1-Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating PTBP1 and FOSL1 Association. (PubMed, Cancers (Basel))

HOXA11-AS1 promoted PD-L1 expression by upregulating FOSL1 levels through PTBP1, thereby facilitating immune escape, proliferation, and metastasis of HSCC cells.

over 3 years ago

Journal • PD(L)-1 Biomarker • IO biomarker

PD-L1 (Programmed death ligand 1) • CD8 (cluster of differentiation 8) • IFNG (Interferon, gamma) • CD4 (CD4 Molecule) • PTBP1 (Polypyrimidine Tract Binding Protein 1) • HOXA11 (Homeobox A11) • HOXA11-AS (HOXA11 Antisense RNA)

PD-L1 expression • CD8 overexpression • HOXA11 overexpression • PTBP1 overexpression

over3years

LncRNA OIP5-AS1 aggravates the stemness of hepatoblastoma through recruiting PTBP1 to increase the stability of β-catenin. (PubMed, Pathol Res Pract)

OIP5-AS1 silencing inhibits the growth and stemness of hepatoblastoma through binding with PTBP1 to inhibit β-catenin signaling pathway. OIP5-AS1 may be the potential target against hepatoblastoma.

over 3 years ago

Journal

CTNNB1 (Catenin (cadherin-associated protein), beta 1) • PTBP1 (Polypyrimidine Tract Binding Protein 1)

PTBP1 overexpression

over3years

PTBP1 is a Novel Poor Prognostic Factor for Glioma. (PubMed, Biomed Res Int)

Furthermore, we shed light on the underlying mechanism of PTBP1 by constructing a miR-218-TCF3-PTBP1 transcriptional network in glioma. PTBP1 was high expressed in glioma, and it significantly correlated with poor prognosis, suggesting a potential therapeutic target for glioma, particularly for GBM.

over 3 years ago

Journal

TCF3 (Transcription Factor 3) • PTBP1 (Polypyrimidine Tract Binding Protein 1) • MIR218 (MicroRNA 218)

PTBP1 overexpression

4years

CircFAM120B knockdown inhibits osteosarcoma tumorigenesis via the miR-1205/PTBP1 axis. (PubMed, Aging (Albany NY))

We hypothesize circFAM120B functions as a miR-1205 sponge to elevate PTBP1 levels, enhancing OS progression and associated malignant phenotypes. Thus, circFAM120B may function as a crucial mediator during OS progression.

4 years ago

Journal

PTBP1 (Polypyrimidine Tract Binding Protein 1) • MIR1205 (MicroRNA 1205)

PTBP1 overexpression

over4years

Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer. (PubMed, Theranostics)

In addition, the transcription of circRHOBTB3 can be improved by both FUS and ADARB2 in CRC cells. Our findings indicate that circRHOBTB3 exerts suppressive effects on CRC aggressiveness through the HuR/PTBP1 axis.

over 4 years ago

Journal

FUS (FUS RNA Binding Protein) • PTBP1 (Polypyrimidine Tract Binding Protein 1) • ELAVL1 (ELAV Like RNA Binding Protein 1)

PTBP1 overexpression

almost5years

KDM5C Expedites Lung Cancer Growth and Metastasis Through Epigenetic Regulation of MicroRNA-133a. (PubMed, Onco Targets Ther)

KDM5C inhibited the expression of miR-133a by promoting the demethylation modification of its promoter histone. Histone demethylase KDM5C inhibits the expression of miR-133a by elevating the demethylation modification of the promoter histone of miR-133a, thereby promoting the expression of PTBP1, which finally accelerates lung cancer cell growth and metastasis.

almost 5 years ago

Journal

KDM5C (Lysine Demethylase 5C) • PTBP1 (Polypyrimidine Tract Binding Protein 1)

PTBP1 overexpression