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    GENE:

    PSMD10 (Proteasome 26S Subunit Non-ATPase 10)

    i
    Other names: PSMD10, Proteasome 26S Subunit Non-ATPase 10, Gankyrin 2, Proteasome (Prosome Macropain) 26S Subunit Non-ATPase 10, 26S Proteasome Non-ATPase Regulatory Subunit 10, 26S Proteasome Regulatory Subunit P28, P28(GANK), P28, Hepatocellular Carcinoma-Associated Protein P28-II, Ankyrin Repeat Protein, DJ889N15.2
    3ms
    Gankyrin-Protein Interactions in GI Cancers: A Novel Target of New Therapeutics. (PubMed, Chronic Dis Transl Med)
    Recent advances have shed light on the structural basis of gankyrin's molecular interactions, its potential as a diagnostic and prognostic biomarker, and emerging therapeutic strategies. Together, targeting gankyrin represents a promising strategy for precision oncology in GI cancers.
    Review • Journal
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    PSMD10 (Proteasome 26S Subunit Non-ATPase 10)
    7ms
    Epstein-Barr virus nuclear antigen 1 upregulates Derlin1 and PSMD10 expression in HeLa cells. (PubMed, Genes Cancer)
    Our findings suggest that increase expression levels of Derlin1 and PSMD10 genes in HeLa cells by the EBV-EBNA1 might induce cancer cell survival and accelerates the development of cervical cancer (CC). However, to establish a conclusive link between EBV-EBNA1 and CC progression, further investigations are warranted.
    Journal
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    PSMD10 (Proteasome 26S Subunit Non-ATPase 10) • ZEB1 (Zinc Finger E-box Binding Homeobox 1) • DERL1 (Derlin 1) • ERLIN1 (ER Lipid Raft Associated 1)
    9ms
    Gankyrin Inhibition Can Control Helicobacter pylori Generated Gastric Cancer Using In Vivo Xenograft Models. (PubMed, Helicobacter)
    These findings suggest that Gankyrin plays a crucial role in H. pylori-mediated GC progression by modulating inflammatory and tumor suppressor pathways. Targeting Gankyrin could provide a therapeutic strategy to mitigate the development of GC associated with H. pylori infection.
    Preclinical • Journal
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    TP53 (Tumor protein P53) • IL6 (Interleukin 6) • TNFA (Tumor Necrosis Factor-Alpha) • PSMD10 (Proteasome 26S Subunit Non-ATPase 10)
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    cyclosporin A microemulsion
    over1year
    Integration of ubiquitination-related genes in predictive signatures for prognosis and immunotherapy response in sarcoma. (PubMed, Front Oncol)
    We discovered a significant correlation between aberrant expression of URGs and prognosis in SARC patients, identifying a prognostic model related to ubiquitination. This model provides a basis for individualized treatment and immunotherapy decisions for SARC patients.
    Journal • IO biomarker
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    CASP3 (Caspase 3) • CALR (Calreticulin) • MIR143 (MicroRNA 143) • MIR503 (MicroRNA 503) • PSMD10 (Proteasome 26S Subunit Non-ATPase 10)
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    EGF expression
    almost3years
    EBNA1 Upregulates P53-Inhibiting Genes in Burkitt's Lymphoma Cell Line. (PubMed, Rep Biochem Mol Biol)
    It seems that EBNA1 could strongly upregulate p53-inhibiting genes including HDAC1, MDM2, MDM4, and USP7. Moreover, it appears that the effects of USP7 suppression on p53 at protein/mRNA level depend on the cell nature; however, further research is needed.
    Preclinical • Journal
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    MDM4 (The mouse double minute 4) • HDAC1 (Histone Deacetylase 1) • SIRT3 (Sirtuin 3) • PSMD10 (Proteasome 26S Subunit Non-ATPase 10) • USP7 (Ubiquitin Specific Peptidase 7)
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    TP53 expression
    3years
    A New Insight Into p53-Inhibiting Genes in Epstein-Barr Virus-Associated Gastric Adenocarcinoma. (PubMed, Iran Biomed J)
    Two events-p53 protein overexpression and apoptosis activation-followed the suppression of the USP7 protein and provided evidence for its possible function. The significance of the EBNA1-USP7 interaction in p53 suppression warrants additional investigation and possibly reconsideration.
    Journal
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    MDM4 (The mouse double minute 4) • HDAC1 (Histone Deacetylase 1) • SIRT3 (Sirtuin 3) • PSMD10 (Proteasome 26S Subunit Non-ATPase 10) • USP7 (Ubiquitin Specific Peptidase 7)
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    TP53 mutation
    over3years
    miR-188-5p and Host MALAT1 Regulate RBE Cell Migration, Invasion, and Apoptosis via Up-regulating PSMD10 in Cholangiocarcinoma. (PubMed, Appl Biochem Biotechnol)
    MALAT1 competitively binds to miR-188-5p to up-regulate mRNA translation and protein expression of PSMD10, thereby facilitating cholangiocarcinoma cell invasion and migration and inhibiting its apoptosis. However, interfering MALAT1-miR-188-5p-PSMD10 axis could inhibit the occurrence and development of cholangiocarcinoma.
    Journal • IO biomarker
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    BCL2 (B-cell CLL/lymphoma 2) • MALAT1 (Metastasis associated lung adenocarcinoma transcript 1) • CASP3 (Caspase 3) • PSMD10 (Proteasome 26S Subunit Non-ATPase 10)
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    BCL2 expression
    over3years
    Hsa-miR-1248 suppressed the proliferation, invasion and migration of colorectal cancer cells via inhibiting PSMD10. (PubMed, BMC Cancer)
    Hsa-miR-1248 may act as a tumor suppressor gene in CRC by targeting and inhibiting PSMD10, which provides a clue for CRC treatment.
    Journal
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    PSMD10 (Proteasome 26S Subunit Non-ATPase 10)
    over3years
    Activating IL-6/STAT3 Enhances Protein Stability of Proteasome 20S α+β in Colorectal Cancer by miR-1254. (PubMed, Biomed Res Int)
    STAT3 could occupy the miR-1254 promoter to inhibit transcription, and it could suppressed miR-1254 which targeted PSMD10, promoting proteasome 20S α+β protein stability. This is a prospective target for developing a new colorectal cancer therapy strategy.
    Journal
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    IL6 (Interleukin 6) • STAT3 (Signal Transducer And Activator Of Transcription 3) • PSMD1 (Proteasome 26S Subunit Non-ATPase 1) • PSMD10 (Proteasome 26S Subunit Non-ATPase 10)
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    IL6 expression
    almost4years
    Novel Nexus with NFκB, β-catenin, and RB1 empowers PSMD10/Gankyrin to counteract TNF-α induced apoptosis establishing its oncogenic role. (PubMed, Int J Biochem Cell Biol)
    Our study, for the first time, shows that PSMD10 is required for the activation of the pro-survival arm via NFκB transcriptional activation to prevent cancer cells from succumbing to TNF-induced cell death. In addition by transcriptional regulation of two major antiapoptotic players RB1 and β-catenin, PSMD10 proves to be a coveted oncoprotein with a key role in tumorigenesis.
    Journal
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    RB1 (RB Transcriptional Corepressor 1) • CTNNB1 (Catenin (cadherin-associated protein), beta 1) • TNFA (Tumor Necrosis Factor-Alpha) • BIRC3 (Baculoviral IAP repeat containing 3) • STAT3 (Signal Transducer And Activator Of Transcription 3) • TNFAIP3 (TNF Alpha Induced Protein 3) • BIRC2 (Baculoviral IAP Repeat Containing 2) • XIAP (X-Linked Inhibitor Of Apoptosis) • PSMD10 (Proteasome 26S Subunit Non-ATPase 10) • RELA (RELA Proto-Oncogene)
    almost4years
    Identification of Tumor-Suppressive miR-30e-3p Targets: Involvement of SERPINE1 in the Molecular Pathogenesis of Head and Neck Squamous Cell Carcinoma. (PubMed, Int J Mol Sci)
    Functional assays by targeting SERPINE1 expression revealed that the malignant phenotypes (e.g., proliferation, migration, and invasion abilities) of HNSCC cells were suppressed by the silencing of SERPINE1 expression. Our miRNA-based approach will accelerate our understanding of the molecular pathogenesis of HNSCC.
    Journal
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    HMGA2 (High mobility group AT-hook 2) • SERPINE1 (Serpin Family E Member 1) • PSMD10 (Proteasome 26S Subunit Non-ATPase 10) • MIR30E (MicroRNA 30e)
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    PAI1 expression • SERPINE1 expression • miR-30e expression