PSMC6 overexpression

PSMC2 and PSMC6 overexpressing cells were also resistant to PI challenge (bortezomib LD50 of 30 nM vs 15 nM in U266 overexpressed and control, bortezomib LD50 of 18 nM vs 10 nM in ARH77 overexpressed vs control cells)... Our results demonstrate that elevated PSMC2 and PSMC6 expression correlates with reduced OS in MM. PSMC subunit inactivation decreased proteasome activity and increased dependence on autophagy, while PSMC upregulation increased proteasome activity and reduced PI sensitivity. Proteasome ATPases are actionable targets with a prognostic and therapeutic role in the armamentarium for MM.