PSMA1 (Proteasome 20S Subunit Alpha 1)

LDOC1-mediated chromatin remodeling, through regulation of H2Bub1 recruitment and turnover, represents a key mechanism promoting NSCLC progression. The LDOC1-H2Bub1 axis, potentially involving THAP12, shapes chromatin accessibility and metastatic transcriptional programs, providing mechanistic and clinical insights into tumor aggressiveness and therapeutic response.

ICU-derived MRSA isolates in southern China display considerable molecular diversity and varying resistance and virulence profiles. CC5, especially ST764, is associated with multidrug resistance and poor clinical outcomes, highlighting the need for enhanced infection control in ICUs.

Salivary exosomes in the UC patients may have the function of promoting inflammation. Analysis of protein levels in the saliva of the UC patients and healthy controls revealed significant differences in the expression levels of 15 co-expressed proteins between the two groups. Among them, C3, PSMA2, PSMB6 and PSMA1 were found to be mainly related to immune and inflammatory reactions in the UC group. These findings suggest that proteins with high specific expression in salivary exosomes of the UC patients have the potential to be used as a disease marker for UC diagnosis and may contribute to the pathogenesis of UC.

In addition, SRSF10 is a downstream binding target of miR-140-3p, and inhibition of SRSF10 also promoted pyroptosis and inhibited glioma cells proliferation and metastasis. In conclusion, our results confirmed that PSMA1-AS1 affects glioma cell proliferation and metastasis by regulating pyroptosis through miR-140-3p/SRSF10 axis, suggesting that LncRNA PSMA1-AS1 may be a potential target for glioma.

③ Finally, we conducted single-cell sequencing analysis and established a prostate cancer organoid model to confirm that TANs may exacerbate the TME in PCa via neutrophil trap formation, which is mediated by the PSMA1-NF-κB-HIF-1α signaling axis. Overall, this novel NET-related signature of PCa provides new insights for in-depth understanding and prediction of PCa prognosis.

MR and mediation analysis revealed that specific GMs influence HNC risk through plasma proteins: Phascolarctobacterium protects against HNC via PSMA1, whereas Ruminococcus increases HNC risk through FAM107B. These pathways suggest that Phascolarctobacterium is a potential preventative factor and that Ruminococcus is a risk factor. This highlights the possibility of using specific GM and plasma proteins as biomarkers or therapeutic targets for HNC prevention, diagnosis, and treatment.

Compound A was well-tolerated in vivo and co-treatment with allogeneic T-cells reduced the growth of myeloma xenotransplants in NSG mice. Taken together, our results demonstrate the paradigm-shifting impact of immunoproteasome activators to diversify the antigenic landscape, expand the immunopeptidome, potentiate T-cell-directed therapy, and reveal actionable neoantigens for personalized T-cell immunotherapy.

Biochemical pathway analysis found that iron supplementation modulated four highly significant (p ≤ 0.05) functional networks. These findings enhance our understanding of interplay between dietary iron and intestinal tumorigenesis and may help develop more specific dietary guidelines regarding trace element intake.

Our study uncovered a novel mechanism through which cisplatin disrupts the BTZ-induced proteasome bounce-back effect by suppressing the ZEB1/Nfe2l1 axis in cholangiocarcinoma. This finding provides a theoretical basis for developing proteasome inhibitor-based strategies for the clinical treatment of cholangiocarcinoma and other tumours.

Dedicated studies on 153 DNA repair genes showed associations for some 30 genes, expression of which could be modified by the implicated variants. We finally point out that monitoring of CAs is so far the only method of assessing cancer risk in healthy human populations, and the use of the technology should be made more attractive by developing automated performance steps and incorporating artificial intelligence methods into the scoring.

PSMA1 upregulation in HNSCC association with adverse clinicopathological features and prognosis underscores its potential significance. Further research is warranted to elucidate its molecular mechanisms and therapeutic potential in OSCC management.

Our findings revealed a key role for RAB31 in GC metastasis through regulation of exosome secretion.