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    1m
    TmPSMA-02 in mCRPC (clinicaltrials.gov)
    P1, N=30, Recruiting, University of Pennsylvania | Active, not recruiting --> Recruiting
    Enrollment open
    |
    TmPSMA-02
    4ms
    TmPSMA-02 in mCRPC (clinicaltrials.gov)
    P1, N=8, Active, not recruiting, University of Pennsylvania | Recruiting --> Active, not recruiting | N=18 --> 8
    Enrollment closed • Enrollment change
    |
    TmPSMA-02
    7ms
    Adoptive Transfer of Autologous T Cells Targeted to Prostate Specific Membrane Antigen (PSMA) for the Treatment of Castrate Metastatic Prostate Cancer (CMPC) (clinicaltrials.gov)
    P1, N=13, Active, not recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Jun 2025 --> Jun 2026 | Trial primary completion date: Jun 2025 --> Jun 2026
    Trial completion date • Trial primary completion date
    |
    cyclophosphamide • engineered autologous T cells
    8ms
    Development of an in situ CAR-T cell protocol through optical and PSMA-targeted PET imaging. (PubMed, Proc Natl Acad Sci U S A)
    Herein, we develop an approach for in situ T cell generation, tracking, and functional assessment using anti-CD5-conjugated lipid nanoparticles for codelivering CD19 CAR mRNA (mCAR19) and a prostate-specific membrane antigen mRNA (mPSMA) tag. With interleukin-7 (IL-7) preconditioning and repeated administration, this approach achieves tumor-free survival in 75% of B cell lymphoma-bearing mice (similar efficacy to ex vivo approaches), and through PET imaging of 68Ga-PSMA-617, the generation and tumor infiltration of in situ-engineered PSMA-tagged CD19 CAR-T cells is validated.
    Journal
    |
    IL7 (Interleukin 7)
    10ms
    Clinical Study of Safety and Efficacy of Universal PSMA CAR- T in Refractory CRPC (clinicaltrials.gov)
    P1, N=3, Recruiting, Shanghai Changzheng Hospital | Not yet recruiting --> Recruiting
    Enrollment open
    10ms
    Clinical Study of Safety and Efficacy of Universal PSMA CAR- T in Refractory CRPC (clinicaltrials.gov)
    P1, N=3, Not yet recruiting, Shanghai Changzheng Hospital
    New P1 trial
    12ms
    P-PSMA-101 CAR-T Cells in the Treatment of Subjects With Metastatic Castration-Resistant Prostate Cancer (mCRPC) and Advanced Salivary Gland Cancers (SGC) (clinicaltrials.gov)
    P1, N=40, Terminated, Poseida Therapeutics, Inc. | N=60 --> 40 | Trial completion date: Sep 2036 --> Sep 2024 | Active, not recruiting --> Terminated; Study closed
    Enrollment change • Trial completion date • Trial termination
    |
    rimiducid (AP1903)
    1year
    GITRL enhances cytotoxicity and persistence of CAR-T cells in cancer therapy. (PubMed, Mol Ther)
    In addition, PSMA-BB-Z-GITRL CAR-T cells produce higher levels of IFN-γ, TNF-α and IL-9 in mouse blood, exhibiting a higher proportion of TCM cells and a lower proportion of Treg cells compared to PSMA-BB-Z CAR-T cells. Our results demonstrate that the overexpression of GITRL has important implications for improving CAR-T cell-based human solid tumor immunotherapy.
    Journal • IO biomarker
    |
    IFNG (Interferon, gamma) • TNFA (Tumor Necrosis Factor-Alpha)
    1year
    CART-PSMA Cells for Advanced Prostate Cancer (clinicaltrials.gov)
    P1, N=20, Recruiting, Nova Therapeutics LLC | Trial primary completion date: Dec 2024 --> Dec 2025
    Trial primary completion date • Metastases
    |
    FOLH1 expression
    |
    cyclophosphamide • CART-PSMA
    over1year
    Adoptive Transfer of Autologous T Cells Targeted to Prostate Specific Membrane Antigen (PSMA) for the Treatment of Castrate Metastatic Prostate Cancer (CMPC) (clinicaltrials.gov)
    P1, N=13, Active, not recruiting, Memorial Sloan Kettering Cancer Center | Trial completion date: Jun 2024 --> Jun 2025 | Trial primary completion date: Jun 2024 --> Jun 2025
    Trial completion date • Trial primary completion date • Metastases
    |
    cyclophosphamide • engineered autologous T cells
    over1year
    GPC3/Mesothelin/Claudin18.2/GUCY2C/B7-H3/PSCA/PSMA/MUC1/TGFβ/HER2/Lewis-Y/AXL/EGFR-CAR-T Cells Against Cancers (clinicaltrials.gov)
    P1, N=30, Recruiting, Second Affiliated Hospital of Guangzhou Medical University | Trial completion date: Aug 2026 --> Aug 2036 | Trial primary completion date: Aug 2024 --> Aug 2026
    Trial completion date • Trial primary completion date • CAR T-Cell Therapy • IO biomarker
    |
    EGFR (Epidermal growth factor receptor) • HER-2 (Human epidermal growth factor receptor 2) • CLDN18 (Claudin 18) • AXL (AXL Receptor Tyrosine Kinase) • MSLN (Mesothelin) • CD276 (CD276 Molecule) • GPC3 (Glypican 3) • TGFB1 (Transforming Growth Factor Beta 1) • GUCY2C (Guanylate Cyclase 2C) • PSCA (Prostate Stem Cell Antigen 2)
    |
    GPC3/Mesothelin/Claudin18.2/GUCY2C/B7-H3/PSCA/PSMA/MUC1/TGFβ/HER2/Lewis-Y/AXL/EGFR-CAR-T cells
    almost2years
    CART-PSMA-TGFβRDN Cells for Castrate-Resistant Prostate Cancer (clinicaltrials.gov)
    P1, N=23, Active, not recruiting, University of Pennsylvania | Recruiting --> Active, not recruiting
    Enrollment closed • Metastases
    |
    TGFB1 (Transforming Growth Factor Beta 1)
    |
    FOLH1 expression
    |
    cyclophosphamide • fludarabine IV • CART-PSMA- TGFβRDN cells