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    BIOMARKER:

    PSIP1 overexpression

    i
    Other names: PSIP1, PC4 And SFRS1 Interacting Protein 1, Lens Epithelium-Derived Growth Factor, DFS70, LEDGF, Dense Fine Speckles 70 KDa Protein, PC4 And SFRS1-Interacting Protein, CLL-Associated Antigen KW-7, PSIP2, PC4 And SFRS1 Interacting Protein 2, Transcriptional Coactivator P52/P75, Transcriptional Coactivator P75/P52
    Entrez ID:
    11168
    Related biomarkers:
    Expression
    2years
    Benign prostatic hyperplasia - A novel autoimmune disease with a potential therapy consequence? (PubMed, Autoimmun Rev)
    New diagnostic options using HEp-2 cells with overexpression of LEDGF/p75 or mitochondrial DNA as autoimmune targets could be used to identify BPH patients with autoimmune responses. Given the presumed involvement of autoimmune responses in BPH and the efficacy of immunosuppression in reducing BPH symptoms, BPH or subvariants of BPH may be candidates for a new autoimmune disease in males.
    Review • Journal
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    PSIP1 (PC4 And SFRS1 Interacting Protein 1)
    |
    PSIP1 expression • PSIP1 overexpression
    almost3years
    Over-Expression of LEDGF/p75 in HEp-2 Cells Enhances Autoimmune IgG Response in Patients with Benign Prostatic Hyperplasia-A Novel Diagnostic Approach with Therapeutic Consequence? (PubMed, Int J Mol Sci)
    In summary, our study provided further evidence for the occurrence of autoimmune responses in BPH. Furthermore, LEDGF/p75 over-expression renders HEp-2 cells more autoantigenic and an ideal target for autoAb analysis in BPH with a potential therapy consequence.
    Journal
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    PSIP1 (PC4 And SFRS1 Interacting Protein 1)
    |
    PSIP1 expression • PSIP1 overexpression
    almost4years
    SPINK5 is a Tumor-Suppressor Gene Involved in the Progression of Nonsmall Cell Lung Carcinoma through Negatively Regulating PSIP1. (PubMed, J Healthc Eng)
    SPINK5 level has a close relation to tumor staging and lymphatic metastasis in NSCLC. It serves as a tumor-suppressor gene that inhibits proliferation and migration of NSCLC through negatively regulating PSIP1.
    Journal
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    PSIP1 (PC4 And SFRS1 Interacting Protein 1)
    |
    PSIP1 overexpression